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| 1 | The P132H mutation in the main protease of Omicron SARSCoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition显示文摘Dear Editor,The ongoing SARS-CoV-2 pandemic continues to be a significant threat to global health.First reported in November 2021,the Omicron variant(B.1.1.529)is more transmissible and can evade immunity better than previous SARS-CoV-2 variants,fueling an unprecedented surge in cases.To produce functional proteins from its polyprotein,SARS-CoV-2 relies on the cysteine proteases Nsp3/papain-like protease(PLpro)and Nsp5/main protease(Mpro)/3C-like protease to cleave at three and more than 11 sites,respectively.1 Therefore,Mpro and PLpro inhibitors are considered to be one of the most promising SARS-CoV-2 antivirals.On December 22,2021,the Food and Drug Administration(FDA)issued an Emergency Use Authorization(EUA)for PAXLOVID,a ritonavir-boosted formulation of nirmatrelvir.Nirmatrelvir is a first-in-class orally bioavailable SARSCoV-2 Mpro inhibitor.2 Thus,the scientific community must vigilantly monitor potential mechanisms of drug resistance,especially because SARS-CoV-2 is naïve to Mpro inhibitors.Mutations have been well identified in variants to this point.3 Notably,Omicron Mpro(OMpro)harbors a single mutation—P132H.In this study,we characterized the enzymatic activity,drug inhibition,and structure of OMpro while evaluating the past and future implications of Mpro mutations. | Michael Dominic Sacco Yanmei Hu Maura Verenice Gongora Flora Meilleur Michael Trent Kemp Xiujun Zhang Jun Wang Yu Chen | 2022 | Cell Research2022，32，5： | 3 |
| 2 | Analysis of motor vehicle ejection victims admitted to a level I trauma center 显示文摘 | Acosta JA Wang DS | 2001 | J Trauma2001，51，5： | 1 |
| 3 | The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28显示文摘 | Tissot C Cerdan C | 2000 | J Interferon Cytokine Res2000，20，11： | 1 |
| 4 | Oxidative stress and hypertension显示文摘 | Harrison DG Gongora MC | 2009 | Med Clin North Am2009，93，3： | 1 |
| 5 | Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid 显示文摘 | Gongora L Manez S Giner RM | 2003 | Planta Med2003，69，5： | 1 |
| 6 | Cardiovascular Complications of Pregnancy显示文摘 | Gongora MC Wenger NK | 2015 | Int J Mol Sci2015，16，23： | 1 |
| 7 | PSP visualization studies on a convergent nozzle with an ejector system 显示文摘 | ZARE - BEHTASH H GONGORA - OROZCO N KONTIS K | 2009 | Journal of Visualization2009，12，2： | 1 |
| 8 | New prenylhydroquinone glycosides from Phagnalon rupestre 显示文摘 | Gongora L Giner R Manez S | 2001 | J Nat Prod2001，64，8： | 1 |
| 9 | Carboplatin hypersensitivity and desensitization in an infant 显示文摘 | MONTIEL H GONGORA M PINEDA M | 2010 | Ther Drug Monit2010，32，4： | 1 |
| 10 | Interferon: andviral mechanisms and viral escape显示文摘 | Espert L Gongora C Mechti N | 2003 | Bull Cancer2003，90，： | 1 |
| 11 | Inactivation of Zygosaccharomyces bailii in fruit juices by heat , high hydrostatic pressure and pulsed electric fields显示文摘 | Raso J Calderon M L Gongora M | 1998 | J Food Sci1998，63，： | 1 |
| 12 | Exploiting the genetic diversity of Beauveria bassiana for improving the biological control of the coffee berry borer through the use of strain mixtures显示文摘 | Cruz L P Gaitan A L Gongora | 2009 | Applied Microbiology and Biotechnology2009，71，6： | 1 |
| 13 | An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons 显示文摘 | Gongora R Stephan R P Zhang Z | 2001 | Immunity2001，14，： | 1 |
| 14 | Altered expression of cell proliferation-related and interferon-stimulated genes in colon cancer cells resistant to SN38显示文摘 | Gongora C Candeil L Vezzio N | 2008 | Cancer Biol Ther2008，7，6： | 1 |
| 15 | Origin and quanti- fication of circulating DNA in mice with human coloreetal canc- er xenografts显示文摘 | Thierry AR Mouliere F Gongora C | 2010 | Nucleic Acids Res2010，38，： | 1 |
| 16 | Circulating miRNA as novel markers for diastolic dysfunction显示文摘 | Nandini Nair Sandeep Kumar Enrique Gongora Sudhiranjan Gupta | 2013 | Molecular and Cellular Biochemistry2013，，： | 1 |
| 17 | Tissue- type plasminogen activator - mediated shedding of astrocytic low - density lipoprotein receptor - related protein increases the permeability of the neurovascular unit显示文摘 | POLAVARAPU R GONGORA M C | 2007 | Blood2007，109，8： | 1 |
| 18 | Tissue-type plasminogen activator-mediated shedding of astrocytic low-denslty lipopmtein re- ceptor-related protein increases the permeability of the neurovascu- lar unit显示文摘 | Polavarapu R Gongora MC Yi H | 2007 | Blood2007，109，8： | 1 |
| 19 | Educational interventions to improve the effectiveness in clinicalcompetence of general practitioners: problem -based versus criticalreading -based learning显示文摘 | Gongora - Ortega J Segovia - Bernal Y Valdivla - Martinez JD | 2012 | BMC Med Educ2012，12，1： | 1 |
| 20 | Influence of several environmental factors on the initiation of germination on Bacillus cereus by high hydrostatic pressure显示文摘 | Raso J Calderon M L Gongora M | 1998 | Int J Food Microbiol1998，44，： | 1 |
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