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| 1 | Prostate cancer upgrading or downgrading of biopsy Gleason scores at radical prostatectomy:prediction of'regression to the mean'using routine clinical features with correlating biochemical relapse rates显示文摘Recommendations for managing clinically localized prostate cancer are structured around clinical risk criteria,with prostate biopsy(PB)Gleason score(GS)being the most important factor.Biopsy to radical prostatectomy(RP)specimen upgrading/downgrading is welldescribed,and is often the ratio nale for costly imaging or genomic studies.We prese nt simple,no-cost an a lyses of clinical parametersto predict which GS 6 and GS 8 patients will change to GS 7 at prostatectomy.From May 2006 to December 2012,1590 patientsunderwent robot-assisted radical prostatectomy(RARP).After exclusions,we identified a GS 6 cohort of 374 patients and a GS 8cohort of 91 patients.During this era,>1000 additional patients were enrolled in an active surveillanee(AS)program.For GS 6,265(70.9%)of 374 patients were upgraded,and the cohort included 183(48.9%)patients eligible for AS by the Prostate Cancer ResearchInternational Active Surveillance Study(PRIAS)standards,of which 57.9%were upgraded.PB features that predicted a>90%chanceof upgrading included≥7 cores positive,maximum foci length≥8 mm in any core,and total tumor involvement≥30%.For GS 8,downgrading occurred in 46(50.5%),which was significantly higher for single core versus multiple cores(80.4%vs 19.6%,P=0.011).Biochemical recurre nee(BCR)occurred in 3.4%of GS 6 upgraded versus 0%non upgraded,and in GS 8,19.6%downgraded versus42.2%nondown graded.In coun seling men with clin ically localized prostate can cer,the odds of GS cha nge should be presented,andcertain men with high-volume GS 6 or low-volume GS 8 can be counseled with GS 7-based recommendations. | Muammer Altok Patricia Troncoso Mary F Achim Surena F Matin Graciela N Gonzalez John W Davis | 2019 | Asian Journal of Andrology2019，21，6： | 4 |
| 2 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 3 | 在经历 transcatheter 的病人的 atrial 纤维性颤动的临床、预示的含意大动脉的阀门培植显示文摘 AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). METHODS: All consecutive patients undergoing TAVI in our hospital were included. The AF group comprised patients in AF at the time of TAVI or with history of AF, and were compared with the SR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 DS 2-VASC stroke risk score and HAS-BLED bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in SR patients. RESULTS: From a total of 34 patients undergoing TAVI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the SR group except for a trend (P = 0.07) for a higher logistic EuroSCORE (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 DS 2-VASC 4.3, mean HAS-BLED 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the SR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and SR groups, respectively, P = NS). CONCLUSION: Patients in AF undergoing TAVI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the SR group, and the prognosis was similar in both groups. | Pablo Salinas Raúl Moreno Luis Calvo Santiago Jiménez-Valero Guillermo Galeote Angel Sánchez-Recalde Teresa López-Fernández Sergio Garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose María Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-Sendón | 2012 | World Journal of Cardiology2012，4，1： | 2 |
| 4 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 5 | hnmobi- lization of candida rugosa lipase on bentonite modified with benzyhriethylammonium chloride 显示文摘 | RAMOS M D GOMEZ G I G GONZALEZ N S | 2014 | Journal of Molecular Catalysis B : Enzymatic2014，，99： | 1 |
| 6 | Tumor microR-NA expression profiling identifies circulating microRNAs for earlybreast cancer detection显示文摘 | Matamala N Vargas MT Gonzalez - Campora R | 2015 | Clin Chem2015，61，8： | 1 |
| 7 | Summary of the consensus document:“Clinical practice guide forthe management of low cardiac output syndrome in the postoperativeperiod of heart surgery”显示文摘 | Pérez Vela JL Martín Benitez JC Carrasco Gonzalez M | 2012 | Medicina Intensiva (EnglishEdition)2012，36，4： | 1 |
| 8 | Effects of enalapril on the vascular wall in an experimental model of syndrome X显示文摘 | Miatello R Risler N Gonzalez S | 2002 | Am J Hypertens2002，1510，1： | 1 |
| 9 | Changes in regional blood-flow distribution and oxygen-supply during hypoxia in conscious rats显示文摘 | Kuwahira I Gonzalez NC Heisler N | 1993 | J Appl Physiol1993，74，1： | 1 |
| 10 | Development of a real-time RT-PCR assay for the detection of Potato spindle tuber viroid显示文摘 | Boonham N Gonzalez Perez L Mendez M S | 2004 | Journal of Virological Methods2004，116，： | 1 |
| 11 | Development and validation of an in Paeient satisfaction ques tionnaire显示文摘 | Gonzalez N Quintana JM Bilbao A | 2005 | Ine J Qual Health Cane2005，17，6： | 1 |
| 12 | Bovine mastitis pathogens in New York and Pennsylvania:prevalence and effects on somatic cell count and milk production显示文摘 | Wilson D J Gonzalez R N Das H H | 1997 | J Dairy Sci1997，80，： | 1 |
| 13 | Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo显示文摘 | Bodine S C Stitt T N Gonzalez M | 2001 | Nature Cell Biol2001，3，： | 1 |
| 14 | C-phycocyanin: a biliprotein with antioxidant, anti-inflammatory and neuroprotective effects 显示文摘 | ROMAY Ch GONZALEZ R LEDON N | 2003 | Curr Protein Pept Sci2003，4，3： | 1 |
| 15 | Molecular analysis of rifampin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in Seville 显示文摘 | Gonzalez N Jtorres M Aznar J C | 1999 | Spain Tubercle and LungDisease1999，79，3： | 1 |
| 16 | Cell-cycle -dependent regulation of DNA replication and its relevance to cancer pathology显示文摘 | Tachibana KE Gonzalez MA Coleman N | 2005 | J Pathol2005，205，2： | 1 |
| 17 | Representations of the Drazin Inverse for a Class of Block Matrices 显示文摘 | Castro Gonzalez N Dopazo E | 2005 | Linear Algebra and Its Appl2005，400，1： | 1 |
| 18 | Additive perturbation results for the Drazin inverse显示文摘 | N Castro Gonzalez | 2005 | Linear Algebra and Its Applications2005，397，： | 1 |
| 19 | Changes in executive control across the life span:examination of task-switching performance 显示文摘 | Cepeda N J Kramer AF Gonzalez de Sather JC | 2001 | Dev Psychol2001，37，5： | 1 |
| 20 | Polypropylene/wood flour composites: treatments and properties 显示文摘 | Ichazo M N Albano C Gonzalez J | 2001 | Compos Struct2001，54，23： | 1 |
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