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| 1 | Gene expression changes in spleens of the wildlife reservoir species,Eurasian wild boar(Sus scrofa),naturally infected with Brucella suis biovar 2显示文摘Brucella suis is responsible for swine brucellosis worldwide.Of the five different B.suis biovars(bv.),bv.2 appears restricted to Europe where it is frequently isolated from wild boar and hares,can infect pigs and can cause human brucellosis.In this study,the differential gene expression profile was characterized in spleens of Eurasian wild boar naturally infected with B.suis bv.2.Of the 20,201 genes analyzed in the microarray,633 and 1,373 were significantly(fold change > 1.8;P < 0.01) upregulated and downregulated,respectively,in infected wild boar.The analysis was focused on genes that were over represented after conditional test for biological process gene ontology.Upregulated genes suggested that B.suis bv.2 infection induced cell maturation,migration and/or proliferation in infected animals.The genes downregulated in infected wild boar impaired the activity of several important cellular metabolic pathways such as metabolism,cytoskeleton organization and biogenesis,immune response and lysosomal function and vesicle-mediated transport.In addition,the response to stress,sperm fertility,muscle development and apoptosis seemed to be also impaired in infected animals.These results suggested that B.suis bv.2 may use strategies similar to other smooth brucellae to facilitate intracellular multiplication and the development of chronic infections.To our knowledge,this is the first report of the analysis of gene expression profile in hosts infected with B.suis bv.2,which is important to understand the molecular mechanisms at the host-pathogen interface in the main reservoir species with possible implications in the zoonotic cycle of the pathogen. | Ruth C.Galindo Pilar M.Muoz María J.de Miguel Clara M.Marin Javier Labairu Miguel Revilla José M.Blasco Christian Gortazar José de la Fuente | 2010 | Journal of Genetics and Genomics2010，37，11： | 6 |
| 2 | Bovine tuberculosis in Donana Biosphere Reserve: the role of wild ungulates as disease reservoirs in the last lberian lynx strongholds显示文摘 | Gortazar C Torres M J VicenteJ | 2008 | Plos One2008，3，7： | 1 |
| 3 | Antibod- ies to selected viral and bacterial pathogens in Europe- an wild boars from southeentral Spain显示文摘 | Vicente J Leon-Vizcaino L Gortazar C | 2002 | J Wildl Dis2002，38，3： | 1 |
| 4 | Both N-and C-terminal domains of parathyroid hormone-related protein increase interleukin-6 by nuclear factor-kappa B activation in osteoblastic cells显示文摘 | Guillen C Martine P de Gortazar AR | 2002 | J Biol Chem2002，277，28： | 1 |
| 5 | Evaluation of instream habitat enhancement options using fish habitat simulations: case-studies in the river Pas (Spain) 显示文摘 | Diego Garcia de Jalon Javier Gortazar | 2007 | Aquatic Ecology2007，41，： | 1 |
| 6 | Evaluation of in- stream habitat enhancement options using fish habitat simulations : case - studies in the river Pas ( Spain ) 显示文摘 | Diego Gareia de Jalon Javier Gortazar | 2007 | Aquatic Ecology2007，41，3： | 1 |
| 7 | Evidence of the role of European wild boar as a reservoir of Mycobacterium tuberculosis complex显示文摘 | Naranjo V Gortazar C Vicente J | 2008 | Vet Microbiol2008，127，12： | 1 |
| 8 | Torque teno virus (TTV) is highly prevalent in the European wild boar (Sus scrofa)显示文摘 | Martinez L Kekarainen T Sibila M Ruiz-Fons F Vidal D Gortazar C Segales J | 2006 | Vet Microbiol2006，118，34： | 1 |
| 9 | Optimal exploration inrestments under price and geological-technical uncertainty: a real options model 显示文摘 | Gortazar G Schwarz E S Casassus J | 2001 | R & D Management2001，31，2： | 1 |
| 10 | Molecular characterization of Mycobacterium tuberculosis complex isolates from wild ungulates in south-central Spain显示文摘 | Gortazar C Vicente J Samper S | 2005 | Vet Res2005，36，： | 1 |
| 11 | A novel ligand- independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction显示文摘 | Aguirre JI Plotkin LI Gortazar AR | 2007 | J Biol Chem2007，282，25： | 1 |
| 12 | Evaluation of instream habitat enhancement options using fish habitat simulations:case-studies in the river Pas (Spain) 显示文摘 | Diego Garcia de Jalon Javier Gortazar | 2007 | Aquatic Ecology2007，41，： | 1 |
| 13 | Bovine tuberculosis in Donana Biosphere Reserve:the role of wild ungulates as disease reservoirs in the last Iberian lynx strongholds显示文摘 | Gortazar C Torres M J Vicente J | 2008 | PLoS One2008，3，7： | 1 |
| 14 | Seroprevalence of Neospora caninum in non-carnivorous wildlife from Spain显示文摘 | S. Almería D. Vidal D. Ferrer M. Pabón M.I.G. Fernández-de-Mera F. Ruiz-Fons V. Alzaga I. Marco C. Calvete S. Lavin C. Gortazar F. López-Gatius J.P. Dubey | 2006 | Veterinary Parasitology2006，，： | 1 |
| 15 | BTV infec- tion in wild ruminants, with emphasis on red deer: a review 显示文摘 | FALCONI C LOPEZ - OLVERA J R GORTAZAR C | 2011 | Vet Microbiol2011，151，34： | 1 |
| 16 | Molecular characterization of Mycobacterium tuberculosis complex isolates from wild ungtflates in south-central Spain显示文摘 | Gortazar C Vicente J Samper S | 2005 | Vet Res2005，36，： | 1 |
| 17 | Evaluation of instream habitat enhancement options using fish habitat simulations: case studies in the river Pas (Spain)显示文摘 | Jalon D G Gortazar J | 2007 | Aquatic Ecology2007，41，： | 1 |
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