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| 1 | 2,2’,4,4’-四溴二苯醚(BDE-47)对大型溞(Daphnia magna)的毒性效应显示文摘2,2’,4,4’-四溴二苯醚(BDE-47)在水体及各种水生生物(鱼类、海洋哺乳动物以及水生无脊椎动物)中被广泛检出,但BDE-47对水生无脊椎动物毒性效应的研究还处于起步阶段。以大型溞(Daphnia magna)为受试生物,通过急性(48h)和慢性(21d)毒性暴露实验,考察了BDE-47对大型溞活动抑制率、心率、产仔情况和酶活性等指标的影响。结果显示,BDE-47对大型溞活动抑制率的48h-EC50为112.5μg.L-1;高浓度(>100μg.L-1)BDE-47显著诱导提高大型溞的心率。21d慢性暴露实验中,8μg.L-1处理组中大型溞全部死亡;其他各浓度处理组(0.5、1、2、4μg.L-1)中,母溞第1胎产仔时间延后,第1胎子代数量减少,总产仔数量大幅减少,这表明大型溞的繁殖能力受到抑制。BDE-47在一定程度上抑制了母溞胆碱酯酶(ChE)和谷胱甘肽硫转移酶(GST)的活性,大型溞体内的代谢机制没有被诱导,神经活性虽被抑制,但抑制率不高。BDE-47大幅诱导过氧化氢酶(CAT)的活性,并呈现一定的剂量效应关系,相对于ChE和GST,CAT对BDE-47暴露更为敏感,可作为BDE-47对大型溞慢性暴露毒性效应的潜在生物标志物。 | 熊勤犁 史雅娟 吕永龙 李秋爽 Gosens Jorrit | 2013 | 生态毒理学报2013，8，1： | 12 |
| 2 | Factors influencing polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (PCDD/F) emissions and control in major industrial sectors: Case evidence from Shandong Province, China显示文摘Analyzing determinants that influence polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran(PCDD/F) emissions is helpful for decision-makers to find effective and efficient ways to mitigate PCDD/F emissions. The PCDD/F emissions and the contributions of the scale effect, structure effect and technology effect to emissions from eight main industrial sectors in2006, 2008 and 2010 in Shandong Province, were calculated in this article. Total PCDD/F emissions in Shandong increased by 52.8% in 2008(614.1 g I-TEQ) and 49.7% in 2010(601.8 g I-TEQ) based on 2006(401.9 g I-TEQ). According to the decomposition method, the largest influencing factor on PCDD/F emission changes was the composition effect(contributed 43.4%in 2008 and 120.6% in 2010 based on 2006), which was also an emission-increasing factor.In this case, the present industrial restructuring policy should be adjusted to control the proportion of production capacities with high emission factors, such as iron ore sintering and steelmaking and the secondary non-ferrous metal sector. The scale effect increased the emissions in 2008(contributed 21.9%) and decreased the emissions in 2010(contributed-28.0%). However, as a source control measure, the excess capacity control policy indeed had a significant role in emission reduction. The main reason for the technology effect(contributed 34.7% in 2008 and 7.4% in 2010 based on 2006) having an emission-increasing role was the weakness in implementing policies for restricting industries with outdated facilities. Some specific suggestions were proposed on PCDD/F reduction for local administrators at the end. | Lin Wang Yonglong Lu Guizhen He Arthur P.J.Mol Tieyu Wang Jorrit Gosens Kun Ni | 2014 | Journal of Environmental Sciences2014，26，7： | 2 |
| 3 | Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle显示文摘 | Gosens R Stelmack GL Dueck G | | 0，，03： | 1 |
| 4 | Insulin induces a hypercontractile airway smooth muscle phenotype显示文摘 | Gosens R Nelemans S A Hiemstra M | 2003 | Eur J Pharmacol2003，481，1： | 1 |
| 5 | Muscarinic M3 - receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle显示文摘 | Gosens R Nelemans S A Grootte Bromhaar M M | 2003 | Am J Respir Cell Mol Biol2003，28，： | 1 |
| 6 | De novo syn- thesis of beta-catenin via H-Ras and MEK regulates air- way smooth muscle growth显示文摘 | Gosens R Baarsma HA Heijink IH | 2010 | FASEB J2010，24，3： | 1 |
| 7 | Activin-A:active in inflammationin COPD显示文摘 | Tania NP Schmidt M Gosens R | 2014 | Eur Respir J2014，43，4： | 1 |
| 8 | Neurovascular complications and functional outcome in displaced supracondylar fractures of the humerus in children显示文摘 | Gosens T Bongers KJ | 2003 | Injury2003，34，4： | 1 |
| 9 | Traumatic thumb carpometacarpal joint disloactions显示文摘 | Bosmans B Verhofstad MH Gosens T | 2008 | J Hand Surg Am2008，33，： | 1 |
| 10 | The GSK - 3/beta - cate- nin - signalling axis in smooth muscle and its relationship with remodelling 显示文摘 | GOSENS R MEURS H SCHMIDT M | 2008 | N aunyn Schmiedebergs Arch Pharmacol2008，378，2： | 1 |
| 11 | Radical resection after IORT-containing multimodality treatment is the most important determinant for outcome in patients treated for locally recurrent rectal cancer 显示文摘 | Dresen RC Gosens M J Rutten HJ | 2008 | Ann Surg Oncol2008，15，7： | 1 |
| 12 | Growth factor-induced contraction of human bronchial smooth muscle is Rho-kinasedependent显示文摘 | Gosens R Schaafsma D Bromhaar M M | 2004 | Eur J Pharmacol2004，494，1： | 1 |
| 13 | Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins显示文摘 | Halayko AJ Tran T Gosens R | 2008 | Proc Am Thorac Soc2008，5，1： | 1 |
| 14 | Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle显示文摘 | Gosens R Stelmack GL Dueck G | 2006 | Am J Physiol Lung Cell Mol Physiol2006，291，3： | 1 |
| 15 | Phenotype and functional plasticity of airway smooth muscle显示文摘 | Halayko A J Tran T Gosens R | 2008 | Proc Am Thorac Soc2008，5，： | 1 |
| 16 | Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis显示文摘 | Gosens T Peerbooms JC van Laar W | | 0，，06： | 1 |
| 17 | 1M21p44 MAP kinase acti- vation is localized to caveolae-free membrane domains in airway smooth muscle显示文摘 | Gosens R Dueck G Gerthoffer WT | 2007 | Am J Physiol Lung Cell Mol Physio12007，292，5： | 1 |
| 18 | Fracture of the scapular body:functional outcome after conservative treatment显示文摘 | Gosens T Speigner B Minekus J | 2009 | J Shoulder Elbow Surg2009，18，3： | 1 |
| 19 | Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells显示文摘 | Gosens R Stelmack GL Bos ST | 2011 | J Cell Mol Med2011，15，： | 1 |
| 20 | Ongoing positive effect of platelet-rieh plasma versus corticosteroid in- jection in lateral epicondylitis: a double-blind randomized con- trolled trial with 2-year follow-up 显示文摘 | GOSENS T PEERBOOMS JC VAN LAAR W | 2011 | Am J Sports Med2011，39，6： | 1 |
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