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| 1 | Exosomal microRNAs as a potential therapeutic strategy in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the fifth most com-mon cancer and the second cause of cancer-related death worldwide. The incidence of HCC is constantly increasing in correlation with the rise in diabetes and obesity, arguing for an urgent need for new developments in the treatment of this lethal cancer. Exosomes are small double-membrane vesicles loaded with distinct cargos, particularly small non-coding RNAs called microRNAs, representative of each donor cell and secreted to affect the features of neighboring cells or recipient cells located further away, like in the case of metastasis. A better understanding of the role of exosomes with a microRNA signature in cancer pathogenesis gave rise to the concept of their use as a noninvasive diagnostic biomarker and in the treatment of cancer, including HCC. In this communication, we review recent works that demonstrate that hepatic stellate cells establish an epigenetic communication with liver cancer cells, which affects their pro-malignant features. If naturally secreted patient-derived exosomes show major limitations concerning their clinical use, bio-engineered exosome mimetics that incorporate controlled components and exhibit no protumoral properties could be promising carriers for the treatment of liver cancers, which is the organ preferentially targeted by systemic injection of exosomes. | Angélique Gougelet | 2018 | World Journal of Hepatology2018，10，11： | 6 |
| 2 | MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation显示文摘A recent work of Iliopoulos et al published in Cell highlighted a circuit orchestrated by microRNAs (miRNAs) that results in liver tumorigenesis and inflammation. This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. These promising data support the use of miRNA mimics or inhibitors as potent therapeutic approaches in liver cancer. | Angélique Gougelet Sabine Colnot | 2013 | World Journal of Gastroenterology2013，19，4： | 2 |
| 3 | Lymphoma and Myeloma Cell Resistance to Cytotoxic Agents and Ionizing Radiations Is Not Affected by Exposure to Anti-IL-6 Antibody 显示文摘 | Angelique Gougelet Adeline Mansuy Jean-Yves Blay | 2009 | PLoS One2009，4，11： | 1 |
| 4 | Proposed triage catego-ries for Large - scale radiation incidents using high - accuracy biodo- simetry methods 显示文摘 | Rea M E Gougelet R M Nicolalde R J | 2010 | Health Phys2010，98，2： | 1 |
| 5 | The view from the trenches: emergency medical response plans 显示文摘 | Gougelet R M Rea M E Nicolalde R J | 2010 | Health Phys2010，98，1： | 1 |
| 6 | Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations显示文摘 | Gougelet A Sartor C Bachelot L | 2015 | Gut2015，，： | 1 |
| 7 | Epigenetic mechanisms of liver tumor resistance to immunotherapy显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor,which stands fourth in rank of cancer-related deaths worldwide.The incidence of HCC is constantly increasing in correlation with the epidemic in diabetes and obesity,arguing for an urgent need for new treatments for this lethal cancer refractory to conventional treatments.HCC is the paradigm of inflammation-associated cancer,since more than 80% of HCC emerge consecutively to cirrhosis associated with a vast remodeling of liver microenvironment.In the recent decade,immunomodulatory drugs have been developed and have given impressive results in melanoma and later in several other cancers.In the present review,we will discuss the recent advancements concerning the use of immunotherapies in HCC,in particular those targeting immune checkpoints,used alone or in combination with other anticancers agents.We will address why these drugs demonstrate unsatisfactory results in a high proportion of liver cancers and the mechanisms of resistance developed by HCC to evade immune response with a focus on the epigeneticrelated mechanisms. | Julie Sanceau Angelique Gougelet | 2021 | World Journal of Hepatology2021，13，9： | 1 |
| 8 | The view from the trenches: part 1 - emergency medical response plans and the need for EPR screening 显示文摘 | Gougelet RM Rea ME Nicolalde RJ | 2010 | Health Phys2010，98，2： | 1 |
| 9 | MicroRNA profiles in osteosarcoma as a predictive tool for ifosfamide response显示文摘 | Gougelet A Pissaloux D Besse A | | 0，，03： | 1 |
| 10 | The view from the trenches:part 1-emergency medical response plans and the need for EPR screening显示文摘 | Gougelet RM Rea ME Nicolalde RJ | 2010 | Health Phys2010，98，2： | 1 |
| 11 | LPS induces rapid IL-10 release by M-CSF conditioned,tolerogenic dendritic cell precursors显示文摘 | Kwan WH Boix C Gougelet N | 2007 | Journal of Leukocyte Biology2007，82，1： | 1 |
| 12 | Micro - RNA profiles in osteosarcoma as a predictive tool for ifosfamide response 显示文摘 | GOUGELET A PISSALOUX D BESSE A | 2011 | Int J Cancer2011，129，3： | 1 |
| 13 | Antitumour activity of an inhibitor of miR-34a in liver cancer with 15-catenin-mutations 显示文摘 | Gougelet A Sartor C Baehelot L | 2015 | Gut2015，，： | 1 |
| 14 | Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response显示文摘 | Gougelet A Pissaloux D Besse A | 2011 | Int J Cancer2011，129，3： | 1 |
| 15 | Estrogen receptor and subtype expression and transactivation capacity are dif- ferentially affected by receptor-, hsp90-and immunophilin-ligands in human breast cancer cells 显示文摘 | Gougelet A Bouclier C Marsaud V | 2005 | Journal of Steroid Biochemistry & Molecular Biology2005，94，： | 1 |
| 16 | microRNA: new diagnostic and thera- peutic tools in liver disease? 显示文摘 | Gougelet A Colnot S | 2013 | Med Sci ( Paris)2013，29，： | 1 |
| 17 | The view from the trenches: part 1-emergency medical response plans and the need for EPR screening 显示文摘 | Gougelet RM Rea ME Nicolalde RJ | 2010 | Health Phys2010，98，2： | 1 |
| 18 | The view from the trenches: emergency medical response plans and the need for EPR screening 显示文摘 | Gougelet R M Rea M E Nicolalde R J | 2010 | Health Physics2010，98，2： | 1 |
| 19 | The view from the trenches: emergency medical response plans显示文摘 | Gougelet R M Rea M E Nicolalde R J | 2010 | Health Phys2010，98，1： | 1 |
| 20 | Proposed triage categories for Large-scale radiation incidents using high-accuracy biodosimetry methods显示文摘 | Rea M E Gougelet R M Nicolalde R J | 2010 | Health Phys2010，98，2： | 1 |
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