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| 1 | Review article: Update on current and emergent data on hepatopulmonary syndrome显示文摘Hepatopulmonary syndrome(HPS) is a frequent pulmonary complication of end-stage liver disease, characterized by impaired arterial oxygenation induced by intrapulmonary vascular dilatation. Its prevalence ranges from 4% to 47% in patients with cirrhosis due to the different diagnostic criteria applied among different studies. Nitric oxide overproduction and angiogenesis seem to be the hallmarks of a complicated pathogenetic mechanism, leading to intrapulmonary shunting and ventilation-perfusion mismatch. A classification of HPS according to the severity of hypoxemia has been suggested. Contrast-enhanced echocardiography represents the gold standard method for the detection of intrapulmonary vascular dilatations which is required, in combination with an elevated alveolar arterial gradient to set the diagnosis. The only effective treatment which can modify the syndrome's natural history is liver transplantation. Although it is usually asymptomatic, HPS imparts a high risk of pretransplantation mortality, independently of the severity of liver disease, while there is variable data concerning survival rates after liver transplantation. The potential of myocardial involvement in the setting of HPS has also gained increasing interest in recent research. The aim of this review is to critically approach the existing literature of HPS and emphasizeunclear points that remain to be unraveled by future research. | Stergios Soulaidopoulos Evangelos Cholongitas George Giannakoulas Maria Vlachou Ioannis Goulis | 2018 | World Journal of Gastroenterology2018，24，12： | 26 |
| 2 | Pneumobilia,chronic diarrhea,vitamin K malabsorption:A pathognomonic triad for cholecystocolonic fistulas显示文摘Cholecystocolonic fistula (CF) is an uncommon type of internal biliary-enteric fistulas, which comprise rare complications of cholelithiasis and acute cholecystitis, with a prevalence of about 2% of all biliary tree diseases. We report a case of a spontaneous CF in a 75-year-old diabetic male admitted to hospital for the investigation of chronic watery diarrhea and weight loss. Massive pneumobilia demonstrated on abdominal ultrasound and computerized tomography, along with chronic, bile acid-induced diarrhea and a prolonged prothrombin time due to vitamin K malabsorption, led to the clinical suspicion of the fistula. Despite further investigation with barium enema and magnetic resonance cholangio-pancreatography, diagnosis of the fistulous tract between the gallbladder and the hepatic flexure of the colon could not be established preoperatively. Open cholecystectomy with fistula resection and exploration of the common bile duct was the preferred treatment of choice, resulting in an excellent postoperative clinical course. The incidence of biliary-enteric fistulas is expected to increase due to the parallel increase of iatrogenic interventions to the biliary tree with the use of endoscopic retrograde cholangio-pancreatography and the increased rate of cholecystectomies performed. Taking into account that advanced imaging techniques fail to demonstrate the fistulas tract in half of the cases, and that CFs usually present with non-specific symptoms, our report could assist physicians to keep a high index of clinical suspicion for an early and valid diagnosis of a CF. | Savvoula Savvidou John Goulis Alexandra Gantzarou George Ilonidis | 2009 | World Journal of Gastroenterology2009，15，32： | 20 |
| 3 | Clinical impact of microbiome in patients with decompensated cirrhosis显示文摘Cirrhosis is an increasing cause of morbidity and mortality. Recent studies are trying to clarify the role of microbiome in clinical exacerbation of patients with decompensated cirrhosis. Nowadays, it is accepted that patients with cirrhosis have altered salivary and enteric microbiome, characterized by the presence of dysbiosis. This altered microbiome along with small bowel bacterial overgrowth, through translocation across the gut, is associated with the development of decompensating complications. Studies have analyzed the correlation of certain bacterial families with the development of hepatic encephalopathy in cirrhotics. In general, stool and saliva dysbiosis with reduction of autochthonous bacteria in patients with cirrhosis incites changes in bacterial defenses and higher risk for bacterial infections, such as spontaneous bacterial peritonitis, and sepsis. Gut microbiome has even been associated with oncogenic pathways and under circumstances might promote the development of hepatocarcinogenesis. Lately, the existence of the oral-gutliver axis has been related with the development of decompensating events. This link between the liver and the oral cavity could be via the gut through impaired intestinal permeability that allows direct translocation of bacteria from the oral cavity to the systemic circulation. Overall, the contribution of the microbiome to pathogenesis becomes more pronounced with progressive disease and therefore may represent an important therapeutic target in the management of cirrhosis. | Theodora Oikonomou George V Papatheodoridis Michael Samarkos Ioannis Goulis Evangelos Cholongitas | 2018 | World Journal of Gastroenterology2018，24，34： | 16 |
| 4 | Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis显示文摘 | Stergios A. Polyzos Konstantinos A. Toulis Dimitrios G. Goulis Christos Zavos Jannis Kountouras | 2011 | Metabolism2011，，3： | 3 |
| 5 | Enhanced recovery after surgery in liver transplantation:Challenges and feasibility显示文摘BACKGROUND Enhanced recovery after surgery(ERAS)started a revolution that changed age-old surgical stereotypical practices regarding the overall management of the surgical patient.In the last decade,ERAS has gained significant acceptance in the community of general surgery,in addition to several other surgical specialties,as the evidence of its advantages continues to grow.One of the last remaining fields,given its significant complexity and intricate nature,is liver transplantation(LT).AIM To investigate the existing efforts at implementing ERAS in LT.METHODS We conducted a systematic review of the existing studies that evaluate ERAS in orthotopic LT,with a multimodal approach and focusing on measurable clinical primary endpoints,namely length of hospital stay.RESULTS All studies demonstrated a considerable decrease in length of hospital stay,with no readmission or negative impact of the ERAS protocol applied to the postoperative course.CONCLUSIONS ERAS is a well-validated multimodal approach for almost all types of surgical procedures,and its future in selected LT patients seems promising,as the preliminary results advocate for the safety and efficacy of ERAS in the field of LT. | Georgios Katsanos Konstantina-Eleni Karakasi Nikolaos Antoniadis Stella Vasileiadou Athanasios Kofinas Antonios Morsi-Yeroyannis Evangelia Michailidou Ioannis Goulis Emmanouil Sinakos Olga Giouleme Ilias Marios Oikonomou George Evlavis Georgios Tsakiris Eleni Massa Eleni Mouloudi Georgios Tsoulfas | 2022 | World Journal of Transplantation2022，12，7： | 3 |
| 6 | Intrapartum application of the continuous glucose monitoring system in pregnancies complicated with diabetes: A review and feasibility study显示文摘Intrapartum maternal normoglycemia seems to play an important role in the prevention of adverse perinatal, maternal and neonatal outcomes. Several glucose monitoring protocols have been developed, aiming to achieve a tight glucose monitoring and control. Depending on the type of diabetes and the optimal or suboptimal glycemic control, the treatment options include fasting status of the parturient, frequent monitoring of capillary blood glucose, intravenous dextrose infusion and subcutaneous or intravenous use of insulin. Continuous glucose monitoring system(CGMS) is a relatively new technology that measures interstitial glucose at very short time intervals over a specifi c period of time. The resulting profi le provides a more comprehensive measure of glycemic excursions than intermittent home blood glucose monitoring. Results of studies applying the CGMS technology in patients with or without diabetes mellitus(DM) have revealed new insights in glucose metabolism. Moreover, CGMS have a potential role in the improvement of glycemic control during pregnancy and labor, which may lead to a decrease in perinatal morbidity and mortality. In conclusion, the use of CGMS, with its important technical advantages compared to the conventional way of monitoring, may lead into a more etiological intrapartum management of both the mother and her fetus/infant in pregnancies complicated with DM. | Vicentia C Harizopoulou Panagiotis Tsiartas Dimitrios G Goulis Dimitrios Vavilis Grigorios Grimbizis Theodoros D Theodoridis Basil C Tarlatzis | 2013 | World Journal of Obstetrics and Gynecology2013，2，3： | 2 |
| 7 | COVID-19 and liver injury: An ongoing challenge显示文摘The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)was identified in December 2019,in Wuhan,China.The virus was rapidly spread worldwide,causing coronavirus disease 2019(COVID-19)pandemic.Although COVID-19 is presented,usually,with typical respiratory symptoms(i.e.,dyspnea,cough)and fever,extrapulmonary manifestations are also encountered.Liver injury is a common feature in patients with COVID-19 and ranges from mild and temporary elevation of liver enzymes to severe liver injury and,even,acute liver failure.The pathogenesis of liver damage is not clearly defined;multiple mechanisms contribute to liver disorder,including direct cytopathic viral effect,cytokine storm and immune-mediated hepatitis,hypoxic injury,and druginduced liver toxicity.Patients with underlying chronic liver disease(i.e.,cirrhosis,non-alcoholic fatty liver disease,alcohol-related liver disease,hepatocellular carcinoma,etc.)may have greater risk to develop both severe COVID-19 and further liver deterioration,and,as a consequence,certain issues should be considered during disease management.The aim of this review is to present the prevalence,clinical manifestation and pathophysiological mechanisms of liver injury in patients with SARS-CoV-2 infection.Moreover,we overview the association between chronic liver disease and SARS-CoV-2 infection and we briefly discuss the management of liver injury during COVID-19. | Ioanna Papagiouvanni Serafeim-Chrysovalantis Kotoulas Athanasia Pataka Dionisios G Spyratos Konstantinos Porpodis Afroditi K Boutou Georgios Papagiouvannis Ioanna Grigoriou Christos Vettas Ioannis Goulis | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 8 | Hepatitis B prophylaxis post liver transplantation with newer nucleos(t)ide analogues after hepatitis B immunoglobulin discontinuation显示文摘 | E. Cholongitas T. Vasiliadis N. Antoniadis I. Goulis V. Papanikolaou E. Akriviadis | 2012 | Transpl Infect Dis2012，，5： | 2 |
| 9 | Risk of gestational diabetes mellitus in women with polycystic ovary syndrome:a systematic review and a metaanalysis显示文摘 | Toulis KA Goulis DG Kolibianakis EM | 2009 | Fertil Steril2009，92，2： | 1 |
| 10 | Epidemiologic analysis of thyroid fine needle aspiration biopsies over a period of 18 years (1987-2004)显示文摘 | POLYZOS SA KITA M GOULIS DG | 2008 | Exp Clin Endocrinol Diabetes2008，116，8： | 1 |
| 11 | Randomised controlled trials of ursodeoxycholic - acid therapy for primary biliary cirrhosis : a meta-analysis 显示文摘 | GOULIS J LEANDRO G BURROUGHS AK | 1999 | Lancet1999，354，： | 1 |
| 12 | Applications and limitations of blood eosinophilia for the diagnosis of acute cellular rejection in liver transplantation显示文摘 | Barnes EJ Abdel-Rehim MM Goulis Y | 2003 | Am J Transplant2003，3，4： | 1 |
| 13 | Ursodeoxycholic acid and histological progression in primary biliary cirrhosis显示文摘 | Chan CW Papatheodoridis GV Goulis J | 2003 | J Hepatol2003，39，6： | 1 |
| 14 | Ectopic thyroid tissue:anatomical,clinical,and surgical implications of a rare entity显示文摘 | NOUSSIOS G ANAGNOSTIS P GOULIS D G | 2011 | Eur J Endocrinol2011，165，： | 1 |
| 15 | Risk ofspontaneous miscarriage in euthyroid women with thyroidautoimmunity undergoing IVF: a meta-analysis 显示文摘 | Toulis KA Goulis DG Venetis CA | 2010 | Eur JEndocrinol2010，162，： | 1 |
| 16 | Serum Osteoprotegerin and RANKL are not Specifically Altered in Women with Postmenopausal Osteoporosis Treated with Teriparatide or Risedronate: A Randomized, Controlled Trial显示文摘 | A. Anastasilakis D. Goulis S. Polyzos S. Gerou G. Koukoulis M. Kita A. Avramidis | 2008 | Horm Metab Res2008，，04： | 1 |
| 17 | Omtreatment prediction of sustained response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B patients 显示文摘 | Goulis I Karatapanis S Akriviadis E | 2015 | Liver Int2015，35，5： | 1 |
| 18 | Serum inhibin-B and follicle stimulating hormone as predictors of the presence of sperm in testicular fine needle aspirate in men with azoospermia显示文摘 | Goulis DG Polychronou P Mikos T | | 0，，： | 1 |
| 19 | Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis 显示文摘 | Polyzos SA Toulis KA Goulis DG | 2011 | Metabolism2011，60，3： | 1 |
| 20 | Ectopic thy- roid tissue:anatomical, clinical,and surgical implications of a rare entity显示文摘 | Noussios G Anagnostis P Goulis D G | 2011 | Eur J Endocrinol2011，165，： | 1 |
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