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| 1 | Cardiovascular disease: Risk factors and applicability of a risk model in a Greek cohort of renal transplant recipients显示文摘AIM To investigate the incidence and the determinants of cardiovascular morbidity in Greek renal transplant recipients(RTRs) expressed as major advance cardiac event(MACE) rate. METHODS Two hundred and forty-two adult patients with a functioning graft for at least three months and availabledata that were followed up on the August 31, 2015 at two transplant centers of Western Greece were included in this study. Baseline recipients' data elements included demographics, clinical characteristics, history of comorbid conditions and laboratory parameters. Follow-up data regarding MACE occurrence were collected retrospectively from the patients' records and MACE risk score was calculated for each patient. RESULTS The mean age was 53 years(63.6% males) and 47 patients(19.4%) had a pre-existing cardiovascular disease(CVD) before transplantation. The mean estimated glomerular filtration rate was 52 ± 17 mL /min per 1.73 m2. During follow-up 36 patients(14.9%) suffered a MACE with a median time to MACE 5 years(interquartile range: 2.2-10 years). Recipients with a MACE compared to recipients without a MACE had a significantly higher mean age(59 years vs 52 years, P < 0.001) and a higher prevalence of pre-existing CVD(44.4% vs 15%, P < 0.001). The 7-year predicted mean risk for MACE was 14.6% ± 12.5% overall. In RTRs who experienced a MACE, the predicted risk was 22.3% ± 17.1% and was significantly higher than in RTRs without an event 13.3% ± 11.1%(P = 0.003). The discrimination ability of the model in the Greek database of RTRs was good with an area under the receiver operating characteristics curve of 0.68(95%CI: 0.58-0.78).CONCLUSION In this Greek cohort of RTRs, MACE occurred in 14.9% of the patients, pre-existing CVD was the main risk factor, while MACE risk model was proved a dependable utility in predicting CVD post RT. | Nikolaos-Andreas Anastasopoulos Evangelia Dounousi Evangelos Papachristou Charalampos Pappas Eleni Leontaridou Eirini Savvidaki Dimitrios Goumenos Michael Mitsis | 2017 | World Journal of Transplantation2017，7，1： | 3 |
| 2 | Transforming growth factor-β1 and myofibroblasts: a potential pathway towards renal scarring inhuman glomerular disease 显示文摘 | GOUMENOS D S TSAMANDAS A C OLDROYD S | 2001 | Nephron2001，87，3： | 1 |
| 3 | Preclnisolone and azathioprine in membranous nephropathy: a 10-year follow-up study显示文摘 | Goumenos D S Ahuja M Davlouros P | 2006 | Clin Nephrol2006，65，5： | 1 |
| 4 | Polymorphomuclear leukocyte rigidity is defective in patients withchronic renal failure显示文摘 | Skoutelis A T Kaleridis V E Goumenos D S | 2000 | Nephrol Dial Transplant2000，15，11： | 1 |
| 5 | What have we learned from the use of eielosporin A in the treatment of nephrotie patients with idiopathic membranous nephropathy 显示文摘 | Goumenos DS | 2008 | Expert Opin Pharmacother2008，9，10： | 1 |
| 6 | Corticosteroids and ciclosporin A in idiopathic membranous nephropathy: higher remission rates of nephrotic syndrome and less adverse reactions than after traditional treatment with cytotoxic drugs显示文摘 | Goumenos D S Katopodis K P Passadakis P | 2007 | Am J Nephrol2007，27，3： | 1 |
| 7 | Prednisolone and azathioprine in IgA nephropathy - a ten-year follow-up study显示文摘 | Goumenos DS Davlouros P EI-Nahas AM | | 0，，： | 1 |
| 8 | Cyclosporin A in adult patients with HenochSch(o)nlein purpura nephritis and nephrotic syndrome:5 case reports显示文摘 | Kalliakmani P Benou E Goumenos DS | 2011 | Clinical Nephrology2011，75，4： | 1 |
| 9 | Myofibroblasts,predictors of progression of mesangial IgA nephropathy?显示文摘 | Brown CB shortland J | 1994 | NephrolDialTransplant1994，9，10： | 1 |
| 10 | The accumulated experience with the use of mycophenolate mofetil in primary glomerulonephritis显示文摘 | Koukoulaki M Goumenos DS | 2010 | Expert Opin Investig Drug2010，19，5： | 1 |
| 11 | Myofibroblasts and the progression of crescentic glomerulonephritis显示文摘 | Goumenos D Tsomi K Iatrou C | 1998 | Nephrol Dial Transplant1998，13，7： | 1 |
| 12 | Does immunosuppression with prednisolone and azathioprine alter the progression of idiopathic membranous nephropathy?显示文摘 | Manohar Ahuja Dimitri Goumenos John R. Shortland Alexander Gerakis Colin B. Brown | 1999 | American Journal of Kidney Diseases1999，，3： | 1 |
| 13 | Endothlin receptors in the kidney of patients with proteinuric and non-proteinurie nephropathies显示文摘 | Drakopoulos A Goumenos DS Vlachojannis JG | 2006 | Renal Failure2006，28，6： | 1 |
| 14 | Transforming growth factor-beta(1) and myofibroblasts:a potential pathway towards renal scarring in human glomerular disease显示文摘 | Goumenos D S Tsamandas A C Oldroyd S | 2001 | Nephron2001，87，3： | 1 |
| 15 | Prednisolone and azathioprine IgA nephropathy a ten-year follow up stady显示文摘 | GOUMENOS D S DAVLOUROS P NAHAS A M | 2003 | Nephron Clin Praet2003，93，2： | 1 |
| 16 | Transforming growth factor-β1 in the kidney and urine of patients with glomerular disease and proteinuria显示文摘 | Goumenos DS Tsakas S El Nahas AM | 2002 | Nephrol Dial Transplant2002，17，12： | 1 |
| 17 | Apoptosis and myofibroblast expression in human glomerular disease: a possible link with transforming growth factor-β-1显示文摘 | Goumenos DS Tsamandas AC Nahas AM | 2002 | Nephron2002，92，： | 1 |
| 18 | Corticosteroids and ciclosporin A in idiopathic membranous nephropathy:higher remission rates of nephrotic syndrome and less adverse reactions than after traditional treatment with cytotoxic drugs显示文摘 | Goumenos DS Katopodis KP Passadakis P | | 0，，03： | 1 |
| 19 | Prednisolone and azathioprine in IgA nephropathy:a ten-year followup study显示文摘 | Goumenos DS Davlouros P E1Nahas AM | 2003 | Nephron Clin Pract2003，93，2： | 1 |
| 20 | Corticosteroids and ciclosporin A in idiopathic membranous nephropathy: higher remission rates of nephrotic syndrome and less adverse reactions than after traditional treatment with cytotoxic drugs显示文摘 | Goumenos DS Katopodis KP Passadakis P | 2007 | Am J Nephrol2007，27，6： | 1 |
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