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| 1 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 2 | HAPEX-SAHEL-A large-scale study of land-atmosphere interactions in the semiarid tropics显示文摘 | Goutorbe J P Lebel T Tinga A | 1994 | Annales Geophysicae1994，12，1： | 1 |
| 3 | An overview of HAPEX-Sahel:a study in climate and desertification显示文摘 | Goutorbe J P Lebel T Tinga A | 1997 | Journal of Hydrology1997，188，： | 1 |
| 4 | Prospective randomized comparison of progressive dilational vs forceps dilational percutaneous tracheostomy显示文摘 | Kaiser E Cantais E Goutorbe P | 2006 | Anaesth Intensive Care2006，34，1： | 1 |
| 5 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 6 | A One-layer Resistance Model for Estimating Regional Evapotranspiration Using Remote Sensing Data显示文摘 | Lemeur R Goutorbe J P | 1995 | Agricultural and Forest Meteorology1995，77，： | 1 |
| 7 | Biliary stenting is not a prereq- uisite to endoscopic placement of duodenal covered self-expandable metal stents 显示文摘 | Poincloux L Goutorbe F Abergel A | 2015 | Surg Endose2015，17，4： | 1 |
| 8 | HAPEX-Sahel: a large-scale study of land-atmosphere interactions in the semi-arid tropics显示文摘 | J.-P. Goutorbe T. Lebel A. Tinga P. Bessemoulin J. Brouwer A. J. Dolman E. T. Engman J. H. C. Gash M. Hoepffner P. Kabat Y. H. Kerr B. Monteny S. Prince F. Said P. Sellers J. S. Wallace | 1994 | Annales Geophysicae1994，，1： | 1 |
| 9 | HAPEX-MOBILHY: A hydrologic atmospheric experiment for the study of water budget and evaporation flux at the climatic scale显示文摘 | Andre J C Goutorbe J P Perrier A | 1986 | Bull Amer Meteor Soc1986，67，2： | 1 |
| 10 | A one-layer resistance model for estimating regional evaporation using remote sensing data显示文摘 | Zhang L R Lemeur Goutorbe J P | 1995 | Agric For Meteorol1995，77，： | 1 |
| 11 | An overview of HAPEX-Sahel:A study in climate and desertification显示文摘 | Goutorbe J P Lebel T Tinga A | 1997 | Journal of Hydrology1997，，188189： | 1 |
| 12 | Regional estimates of heat and evaporation fluxes over non-homogeneous terrain, examples from the HAPEX-MOB1LHY program 显示文摘 | Andre J C Bougeauh Ph Goutorbe J P | 1990 | Boundary-Layer Meteorology1990，50，： | 1 |
| 13 | Prospective randomized comparison of progressive dilational vs forceps dilational percutaneous tracheostomy显示文摘 | Kaiser E Cantais E Goutorbe P | 2006 | Anaesth Intensive Care2006，34，1： | 1 |
| 14 | Prospective randomized comparison of progressive dilational vs forceps dilational percutaneous tracheostomy显示文摘 | Kaiser E Cantais E Goutorbe P | 2006 | Anaesth Intensive Care2006，34，1： | 1 |
| 15 | A one-layer resistance model for estimating regional evapotranspiration using remote sensing data显示文摘 | Zhang L Lemeur R Goutorbe J P | 1995 | Agricultural and Forest Meteorology1995，77，： | 1 |
| 16 | The role of the land surface in sahelian climate : Hapex-sahel results and future research needs 显示文摘 | Dolman A J Gash J H C Goutorbe J P | 1997 | Journal of Hydrology1997，，： | 1 |
| 17 | Prospective randomized comparison of progressive dilational vs forceps dilational percuta- neous tracheostomy显示文摘 | Kaiser E Cantais E Goutorbe P | 2006 | Anaesth Intensive Care2006，34，1： | 1 |
| 18 | HAPEX-Sahel-a large-scale study of land-atmosphere interactions in the semi-arid Tropics显示文摘 | Lebel T Tinga A | 1994 | Annales Geophysicae1994，12，1： | 1 |
| 19 | An overview of HAPEX-Sahel:a study in climate and desertification显示文摘 | Lebel T Tinga A | 1997 | J Hydrology1997，，188189： | 1 |
| 20 | Generation and analysis of soybean plastid transformants expressing Bacillus thuringiensts/erylAb protoxin显示文摘 | DUFOURMANTEL N TISSOT G GOUTORBE F GARCON F MUHR C JANSENS S PELISSIER B PELTIER G DUBALD M | 2005 | Plant Molecular Biology2005，58，5： | 1 |
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