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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | 城市家庭吸烟状况与控制吸烟对策措施显示文摘目的了解城市家庭及其成员吸烟状况,掌握城市家庭及其成员对吸烟的知识-态度-行为(KAP)及影响KAP的因素,为控烟提出对策和建议。方法在南京市主城区按整群分层随机抽取方法抽出419户家庭,每个家庭抽取1名家庭成员作为代表填写答卷,对获得的409份合格问卷进行描述性统计、检验和Logistic分析。结果家庭现在吸烟率68.2%,家庭曾经吸烟率90.2%;家庭成员代表个人的现在吸烟率31.5%,个人曾经吸烟率39.9%。个人第一次尝试吸烟年龄≤18岁的占46.6%;第一次使用香烟来源于朋友的占48.1%。曾经吸烟家庭成员代表的香烟知识态度得分显著低于从不吸烟家庭成员代表(P<0.05)。曾经吸烟家庭中三种吸烟限定对其成员的知识态度得分差异有显著性(P<0.05)。现在吸烟家庭的成员代表和现在不吸烟家庭的成员代表的知识态度得分差异有显著性(P<0.05)。女性、已婚、有职业的人群KAP得分较高。控烟健康教育的主要内容是:充分认识吸烟损害健康;吸烟不是交际手段;对周围人吸烟反感;自己同龄人大部分不吸烟。结论家庭是戒烟、控烟的主要场所和关键平台。已婚女性是戒烟、控烟的关键依靠人群。儿童青少年是控烟的关键目标人群。不敬烟、不劝烟是控烟的关键措施。 | 王此隐 Ma Grace 翟成凯 曹佩 陈学芬 周薇薇 翟书蒙卉 | 2009 | 卫生研究2009，38，1： | 19 |
| 3 | Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo显示文摘 | Huanjie Shao Chun Gao Haikuo Tang Hao Zhang Lewis R. Roberts Bonnie L. Hylander Elizabeth A. Repasky Wen W. Ma Jingxin Qiu Alex A. Adjei Grace K. Dy Chunrong Yu | 2011 | Journal of Hepatology2011，，1： | 2 |
| 4 | COOPERATIVE DIRECTIONAL INTER-CELL HANDOVER SCHEME IN HIGH ALTITUDE PLATFORM COMMUNICATIONS SYSTEMS显示文摘A novel Cooperative Directional inter-cell Handover Scheme(CDHS) for High Altitude Platform(HAP) communications systems is proposed,in which the handover target cell and the two cells adjacent to this handover target cell work cooperatively to exploit the traffic fluctuation to improve handover performance.Users in the overlap area of the overloaded handover target cell will be forced to handover directionally before their optimal handover boundary in order to free up resources for the handover calls which would otherwise be dropped due to the shortage of resources and queue time out.Simulation results show that the handover call dropping probability is greatly reduced(at least 60%) compared with the general queue handover scheme,with little performance reduction to the call blocking probability,and the Not in the Best Cell(NBC) average time is only increased moderately.Moreover,an optimal cell radius can be achieved for a specific platform speed by minimizing the unified system performance,which is the linear combination of the handover call dropping probability and the NBC average time. | Li Shufeng Wang Lijie David Grace Ma Dongtang | 2011 | Journal of Electronics(China)2011，28，2： | 2 |
| 5 | Seasonal and population differences in migration of Whimbrels in the East Asian–Australasian Flyway显示文摘Background:Conserving migratory birds is challenging due to their reliance on multiple distant sites at different stages of their annual life cycle.The concept of“flyway”,which refers to all areas covered by the breeding,nonbreeding,and migrating of birds,provides a framework for international cooperation for conservation.In the same flyway,however,the migratory activities of the same species can differ substantially between seasons and populations.Clarifying the seasonal and population differences in migration is helpful for understanding migration ecology and for identifying conservation gaps.Methods:Using satellite‑tracking we tracked the migration of Whimbrels(Numenius phaeopus variegatus)from nonbreeding sites at Moreton Bay(MB)and Roebuck Bay(RB)in Australia in the East Asian-Australasian Flyway.Mantel tests were used to analyze the strength of migration connectivity between the nonbreeding and breeding sites of MB and RB populations.Welch’s t test was used to compare the migration activities between the two populations and between northward and southward migration.Results:During northward migration,migration distance and duration were longer for the MB population than for the RB population.The distance and duration of the first leg flight during northward migration were longer for the MB population than for the RB population,suggesting that MB individuals deposited more fuel before departing from nonbreeding sites to support their longer nonstop flight.The RB population exhibited weaker migration connectivity(breeding sites dispersing over a range of 60 longitudes)than the MB population(breeding sites concentrating in a range of 5 longitudes in Far Eastern Russia).Compared with MB population,RB population was more dependent on the stopover sites in the Yellow Sea and the coastal regions in China,where tidal habitat has suffered dramatic loss.However,RB population increased while MB population decreased over the past decades,suggesting that loss of tidal habitat at stopover sites had less impact on the Whimbrel populations,which can use diverse habitat types.Different trends between the populations might be due to the different degrees of hunting pressure in their breeding grounds.Conclusions:This study highlights that conservation measures can be improved by understanding the full annual life cycle of movements of multiple populations of Whimbrels and probably other migratory birds. | Fenliang Kuang Jonathan TColeman Chris JHassell Kar‑Sin KLeung Grace Maglio Wanjuan Ke Chuyu Cheng Jiayuan Zhao Zhengwang Zhang Zhijun Ma | 2020 | Avian Research2020，11，3： | 2 |
| 6 | TRPA1 agonists evoke coughing in Guinea pig and human volunteers显示文摘 | Birrell MA Belvisi MG Grace M | 2009 | Am J Respir Crit Care Med2009，180，11： | 1 |
| 7 | Optimisation,validation and application of a capillary electrophoresis method for the determination of ranitidine hydrochloride and related substances显示文摘 | KELLY MA ALTRIA KD GRACE C | 1998 | J Chromatogr A1998，798，1： | 1 |
| 8 | Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin显示文摘 | Grace M Birrell MA Dubuis E | 2012 | Thorax2012，67，10： | 1 |
| 9 | From Guangzhou to Yiwu: E- merging Facets of the African Diaspora in China显示文摘 | Bodomo Adams and Grace Ma | 2010 | Internation- al Journal of African Renaissance Studies2010，5，2： | 1 |
| 10 | A framework for adap-tive content delivery in heterogeneous network environments 显示文摘 | Wei-Ying Ma Ilja Bedner Grace Chang | 2005 | Hewlett-Packard Laboratories2005，，： | 1 |
| 11 | Evidence of augmented central pain processing in idiopathic chronic low back pain显示文摘 | Giesecke T Gracely RH Grant MA | 2004 | Arthritis Rheum2004，50，： | 1 |
| 12 | Risk Perceptions and Barriers to Hepatitis B Screening and Vaccination among Vietnamese Immigrants显示文摘 | Grace X. Ma Carolyn Y. Fang Steven E. Shive Jamil Toubbeh Yin Tan Philip Siu | 2007 | Journal of Immigrant and Minority Health2007，，3： | 1 |
| 13 | Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin显示文摘 | Grace M Birrell MA Dubuis E | 2012 | Thorax2012，67，10： | 1 |
| 14 | Evidence for up-regulated central nociceptive processing in patients with masticatory myofascial pain显示文摘 | Sarlani E Grace EG Reynolds MA | 2004 | J Orofac Pain2004，18，1： | 1 |
| 15 | Pharmacologic therapy of portal hy- pertension 显示文摘 | Minor MA Grace ND | 2006 | Clin Liver Dis2006，10，3： | 1 |
| 16 | Evidence for up-regulated centl'al nociceptive processing in patienls with masticatory myofascialpain显示文摘 | Sarlani E Grace EG Reynolds MA | 2004 | J Orofac Pain2004，18，1： | 1 |
| 17 | The ophylline inhibits the cough reflex through a novel mechanism of action显示文摘 | Dubuis E Wortley MA Grace MS | 2014 | J Allergy Clin Immunol2014，133，6： | 1 |
| 18 | Transient receptor potential channels mediate the tussive response to prostaglandin E2 and Bradykinin显示文摘 | Grace M Birrell MA Dubuis E | 2012 | Thorax2012，67，： | 1 |
| 19 | Selenium and zinc levels in surgical patients receiving total parenteral nutrition显示文摘 | Alfieri MA Leung FY Grace DM | 1998 | Biol Trace Elem Res1998，61，： | 1 |
| 20 | Diagnosing sensory ab- normalities with either normal values or values from contralateral skin : comparison of two approaches in complex regional pain syn- drome I显示文摘 | Kemler MA Schouten HJ Gracely RH | 2000 | Anesthesiology2000，95，3： | 1 |
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