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| 1 | Amnion epithelial cells——a novel therapy for ischemic stroke?显示文摘Stroke is a leading cause of death and disability and new therapies are desperately needed. Given the complex nature of ischemic brain injury, it has been postulated that cell-based therapies may be useful. However, cell resources, invasive extraction procedures, immunological rejection, tumorigenesis and ethical challenges make it unlikely that many stem cell types could serve as a practical source for therapy. By contrast, these issues do not pertain to human amnion epithelial cells(h AECs), which are placenta-derived stem cells. We recently assessed the effects of systemically delivered hAECs on stroke outcome using four animal models of stroke. We demonstrated that when injected intravenously after ischemia onset, hAECs migrate preferentially to the spleen and injured brain to limit apoptosis and inflammation, and attenuate early brain infiltration of immune cells, progression of infarction and systemic immunosuppression and to ultimately ameliorate functional deficits. When administration of hAECs is delayed by 1-3 days poststroke, long-term functional recovery can still be enhanced in young and aged mice of either sex. Moreover, our proof-of-principle findings suggest that h AECs are effective at limiting post-stroke infarct development in non-human primates. Overall, the results suggest that hAECs could be a viable clinical stroke therapy. | Megan A.Evans Brad R.S.Broughton Grant R.Drummond Henry Ma Thanh G.Phan Euan M.Wallace Rebecca Lim Christopher G.Sobey | 2018 | Neural Regeneration Research2018，13，8： | 4 |
| 2 | The mitochondrial genome encodes abundant small noncoding RNAs显示文摘识别的小 noncoding RNA 都被原子染色体远因此编码。这里,我们主要报导鼠科、人的 mitochondrial 染色体编码几千小 noncoding RNA,它是源于 mitochondrial 基因(主人基因) 的感觉抄本,并且我们称为这些小 RNA mitochondrial 编码染色体的小 RNA (mitosRNAs ) 。影响的 DICER inactivation,但是完全没废除 mitosRNA 生产。MitosRNAs 看起来是当前未辩别出的 mitochondrial ribonucleases 的产品。提高的表示在 vitro 他们的主人基因铺平的 mitosRNAs 的 Overexpression,和 dysregulated mitosRNA 表示通常在 vivo 与异常 mitochondrial 基因表示被联系。我们的数据证明除了 37 已知的 mitochondrial 基因,哺乳动物的 mitochondrial 染色体也编码丰富的 mitosRNAs,它可以在房间在 mitochondrial 基因表示的控制起一个重要规章的作用。 | Seungil Ro Hsiu-Yen Ma Chanjae Park Nicole Ortogero Rui Song Grant W Hennig Huili Zheng Yung-Ming Lin2 Loredana Moro Jer-Tsong Hsieh wei Yant | 2013 | Cell Research2013，23，6： | 3 |
| 3 | Absolute and relative value of patient simulator features as perceived by medical undergraduates显示文摘 | Grant T McNeil MA Luo XH | 2008 | Society for Simulation in Healthcare2008，3，3： | 1 |
| 4 | Sublethal levels of oxidant stress stimulate multiple serine! threonine kinases and suppress protein phosphatases in Jurkat T cells 显示文摘 | Whisler RL Goyette MA Grants IS | 1995 | Arch Biochem Biophys1995，319，： | 1 |
| 5 | Polarization insensitive terahertz metamaterial absorber显示文摘 | Grant J Ma Y Saha S | | 0，，08： | 1 |
| 6 | Polarization insensitive,broadband terahertz metamaterial absorber显示文摘 | Grant J Ma Y | | 0，，17： | 1 |
| 7 | A Terahertz polarization insensitive dual band meta- material Absorber 显示文摘 | Ma Y Chen Q Grant J Saha S C Khalid A Cumming D R | 2011 | Optics Letters2011，36，6： | 1 |
| 8 | Brain amy- loid-13 oligomers in ageing and Alzheimer's disease 显示文摘 | LESNE SE SHERMAN MA GRANT M etal | 2013 | Brain2013，136，5： | 1 |
| 9 | Dysfunctional CD39POS regulatory T cells and aberrant control of T‐helper type 17 cells in autoimmune hepatitis显示文摘 | Charlotte R. Grant Rodrigo Liberal Beth S. Holder John Cardone Yun Ma Simon C. Robson Giorgina Mieli‐Vergani Diego Vergani Maria Serena Longhi | 2014 | Hepatology2014，，： | 1 |
| 10 | Growth curve for girls with Turner syndrome显示文摘 | Lyon AJ Preece MA Grant DB | 1985 | Arch Dis Child1985，60，： | 1 |
| 11 | Defining sedation-related adverse events in the pediatric intensive care unit显示文摘 | Grant MJ Balas MC Curley MA | 2013 | Heart Lung2013，42，3： | 1 |
| 12 | Gastrostomy placemem and mortality among hospitalized Medicare beneficiaries 显示文摘 | Grant MD Rudberg MA Brody JA | 1998 | JAMA1998，279，24： | 1 |
| 13 | Effectiveness of feeding tubes in nursing home residents with swallowing disorders 显示文摘 | Rudberg MA Egleston BL Grant MD | 2000 | JPEN J Parenter Enteral Nutr2000，24，2： | 1 |
| 14 | Brain amyloid-β oligomers in aging and Alzheimer's disease 显示文摘 | Lesn6 SE Sherman MA Grant M | 2013 | Brain2013，136，： | 1 |
| 15 | Growth curve for girls with Tumer syndrome显示文摘 | Lyon AJ Preece MA Grant DB | | 0，，10： | 1 |
| 16 | Absolute and relative value of patient simulator features as perceived by medical undergraduates显示文摘 | Grant T McNeil MA Luo XH | 2008 | Society for Simulation in Healthcare2008，3，3： | 1 |
| 17 | Depressed mood in chronic low back painz relationship with stressful life events 显示文摘 | Atkinson JH Salter MA Grant I | 1988 | Pain1988，35，1： | 1 |
| 18 | A Terahertz Polari- zation Incensitive Dual Band Metamaterial Absorber显示文摘 | MA Y CHEN Q GRANT J | 2011 | Optics Letters2011，36，6： | 1 |
| 19 | Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes 显示文摘 | Brown MA Haughton MA Grant SF | 2001 | J Bone Miner Res2001，16，4： | 1 |
| 20 | Glucose tolerance, insulin secretion,insulin sensitivity and glucose effectiveness in normal and overweight hyperthyroid woment显示文摘 | GONZALO MA GRANT C MORENO I | 2007 | Clin Endocrinol Oxf2007，，： | 1 |
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