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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Dissipation in adiabatic shear bands显示文摘 | Grady D E | 1994 | Mechanics of Materials1994，17，1： | 2 |
| 3 | Fragmentation of metal rings by electromagnetic loading 显示文摘 | Grady D E Benson D A | 1983 | Experimental Mechanics1983，23，4： | 1 |
| 4 | Scattering as a Mechanism for Structured Shock Waves in Metals显示文摘 | Grady D | 1998 | J Mech Phys Solids1998，46，10： | 1 |
| 5 | The Spall Strength of Condensed Matter显示文摘 | Grady D E | 1988 | J Meeh Phys Solids1988，36，3： | 1 |
| 6 | Postmenopausal hormones and incontinence:The heart and estrogen/progestin replacement study显示文摘 | Grady D Brown J S Vittinshof E | 2001 | Obstet Gynecol2001，97，1： | 1 |
| 7 | Continuum modeling of explosive fracture in oil shale显示文摘 | Grady D E Kipp M L | 1980 | International Journal of Rock Me- chanics and Mining Sciences1980，17，3： | 1 |
| 8 | Local Inertial Effects in Dynamic Fragmentation显示文摘 | Grady D E | 1982 | J Appl Phys1982，53，1： | 1 |
| 9 | Hormone therapy to prevent disease and prolong life in postmenopausal women显示文摘 | Grady D Rubin S M Petitti D B | 1992 | Ann Intern Med1992，117，12： | 1 |
| 10 | The spall strength of condensed matter显示文摘 | GRADY D E | 1988 | Journal ofthe Mechanics and Physics of Solids1988，36，3： | 1 |
| 11 | Reviews:Hormone replace ment the rapy and endometrial cancer risk:A meta-analysis显示文摘 | Grady D Gebretsadik T Kerlikowske K | 1995 | Obstet Gyneclo1995，85，2： | 1 |
| 12 | The micromechanics of impact fracture of rock显示文摘 | GRADY D E KIPP M E | 1976 | Int J Rock Mech Min Sci & Geomech Abstr1976，16，： | 1 |
| 13 | Hormone replacement therapy and endometrial cancer risk:a meta- analysis显示文摘 | Grady D Gebretsadik T Kerlikowske K | 1995 | Obstet Gynecol1995，85，： | 1 |
| 14 | High rates of perinatal group B Streptococcus clindamycin and erythromycin resistance in an upstate New York hospital显示文摘 | Back E E O'Grady E J Back J D | 2012 | Antimicrob Agents Chemother2012，56，： | 1 |
| 15 | Hormone replacement therapy, heart disease, and other considerations显示文摘 | Grady D | 1998 | Annu Rev Public Health1998，19，1： | 1 |
| 16 | Neuroimaging the serial position curve显示文摘 | GRADY C L GOSHEN-GOTTSTEIN Y MOSCOVITCH M | 2005 | American Psychological Society2005，16，9： | 1 |
| 17 | Hydroxyl radical production during oxidative deposition of iron in ferritin显示文摘 | Grady J K Chen Y Chasteen N D | 1989 | J Biol Chem1989，264，20： | 1 |
| 18 | The micromechanics of impact fracture of rock显示文摘 | GRADY D E KIPP M E | 1979 | International Journal of Rock Mechanics and Mining Sciences and Geomechanics Abstracts1979，16，6： | 1 |
| 19 | Aspects of the phylogeny of the Trematoda Rudolphi, 1808 ( Platyhelminthes : Cercomeria) 显示文摘 | Brooks D R Bandoni S M Grady R T | 1989 | Can J Zool1989，67，： | 1 |
| 20 | 'Postnaenopansal'hormones and incontinence:The heart and estrogen/progestin replacement study 显示文摘 | Grady D Brown J S Vittinshof E | 2001 | Obstet Gynecol2001，97，1： | 1 |
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