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| 1 | Natural killer cell-triggered vascular transformation:maternal care before birth?显示文摘Natural killer(NK)cells are found in lymphoid and non-lymphoid organs.In addition to important roles in immune surveillance,some NK cells contribute to angiogenesis and circulatory regulation.The uterus of early pregnancy is a non-lymphoid organ enriched in NK cells that are specifically recruited to placental attachment sites.In species with invasive hemochorial placentation,these uterine natural killer(uNK)cells,via secretion of cytokines,chemokines,mucins,enzymes and angiogenic growth factors,contribute to the physiological change of mesometrial endometrium into the unique stromal environment called decidua basalis.In humans,uNK cells have the phenotype CD56^(bright) CD16^(dim) and they appear in great abundance in the late secretory phase of the menstrual cycle and early pregnancy.Gene expression studies indicate that CD56^(bright) CD16^(dim) uterine and circulating cells are functionally distinct.In humans but not mice or other species with post-implantation decidualization,uNK cells may contribute to blastocyst implantation and are of interest as therapeutic targets in female infertility.Histological and genetic studies in mice first identified triggering of the process of gestation spiral arterial modification as a major uNK cell function,achieved via interferon(IFN)-c secretion.During spiral arterial modification,branches from the uterine artery that traverse the endometrium/decidua transiently lose their muscular coat and ability to vasoconstrict.The expression of vascular markers changes from arterial to venous as these vessels dilate and become low-resistance,high-volume channels.Full understanding of the vascular interactions of human uNK cells is difficult to obtain because endometrial time-course studies are not possible in pregnant women.Here we briefly review key information concerning uNK cell functions from studies in rodents,summarize highlights concerning human uNK cells and describe our preliminary studies on development of a humanized,pregnant mouse model for in vivo investigations of human uNK cell functions. | Jianhong Zhang Zhilin Chen Graeme N Smith B.Anne Croy | 2011 | Cellular & Molecular Immunology2011，8，1： | 19 |
| 2 | A polyketide synthase in glycopeptide biosynthesis 显示文摘 | Volker Pfeifer Graeme J N Johannes R | 2001 | J Biol Chem2001，276，38： | 1 |
| 3 | Expres- sion of anti-M llerian hormone during normal and patho- logical gonadal development association with differentiation of Sertoli and granulosa cells显示文摘 | Rajpert-DeMeyts E Jorgensen N Graem N | 1999 | J Clin Endocrinol Metab1999，84，38： | 1 |
| 4 | Expression of anti-müllerian hormone during normal and pathological gonadal development:association with differentiation of Sertoli and granulosa cells显示文摘 | Rajpert -De Meyts E Jorgensen N Graem N | 1999 | J Clin Endocrinol Metab1999，84，： | 1 |
| 5 | Managing crop residues,fertilizers and leaf litters to improve soil C,nutrient balances,and the grain yield of rice and wheat cropping systems in Thailand and Australia显示文摘 | Anthony W Graeme B Yothin K Rod L Kunnika N | | 0，，： | 1 |
| 6 | Expression of anti - Mullerian hormone during normal and pathological gonadal development : association with differentiation of Sertoli and granulo- sa cells 显示文摘 | Rajpert - De Meyts E Jrgensen N Graem N | 1999 | Clin Endocrinol Metab1999，84，10： | 1 |
| 7 | Expression of anti-Müllerian hormone during normal and pathological gonadal development:association with differentiation of Sertoli and granulosa cells显示文摘 | Rajpert-De Meyts E Jorgensen N Graem N | 1999 | Journal of Clinical Endocrinology and Metabolism1999，84，： | 1 |
| 8 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 9 | Receptor for urokinase is present in tumor-associated macrophages in duc- tal breast carcinoma 显示文摘 | PYKE C GRAEM N RALFKIAER E | 1993 | Cancer Res1993，53，8： | 1 |
| 10 | Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor显示文摘 | Graeme N Smith Mark C Walker Ame Ohlsson M | 2007 | Am J Obstet Gynecol2007，37，： | 1 |
| 11 | Accuracy of frozen section diagnosis:a retrospective analysis of 4785 cases 显示文摘 | WINTHER C GRAEM N | 2011 | APMIS2011，119，45： | 1 |
| 12 | A new fuzzy dynamic programming approach for solving the hydrothermal scheduling problem显示文摘 | Graeme G Hiroyuki K Ken-ichi N | 1997 | The Transactions of the Institute of Electrical Engineers of Japan:A Publication of Power and Energy Society1997，117，4： | 1 |
| 13 | Expression ofanti-Mullerian hormone during normal and pathological gonadaldevelopment:association with differentiation of Sertoli and granulo-sa cells显示文摘 | Rajpert-De Meyts E Jorgensen N Graem N | 1999 | J Clin Endocrinol Metab1999，84，10： | 1 |
| 14 | The application of fuzzy theory to thermal generating unit maintenance scheduling in power systems显示文摘 | Graeme G Hiroyuki K Ken-ichi N | 1994 | The Transactions of the Institute of Electrical Engineers of Japan:A Publication of Power and Energy Society1994，114，6： | 1 |
| 15 | Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation显示文摘 | Michela N Graeme M Kyle N | 2004 | Circ Res2004，94，： | 1 |
| 16 | Expression of anti-Mtillerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells显示文摘 | Rajpert De Meyts E Jorgensen N Graem N | 1999 | J Clin Endocrinol Metab1999，84，10： | 1 |
| 17 | Modeling of bipolar HVDC links in the harmonic domain显示文摘 | Graeme N Buthurst Nevill R Waston | 2000 | IEEE Transactions on Power Delivery2000，15，3： | 1 |
| 18 | A ran- domised controlled trial of a self - management education program for osteoarthritis of the knee delivered by health care professionals 显示文摘 | Sophie Colemanl N Kathryn Briffal Graeme Carroll | 2012 | Arthritis Research & Therapy2012，14，： | 1 |
| 19 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial显示文摘 | Bernard Nordlinger Halfdan Sorbye Bengt Glimelius Graeme J Poston Peter M Schlag Philippe Rougier Wolf O Bechstein John N Primrose Euan T Walpole Meg Finch-Jones Daniel Jaeck Darius Mirza Rowan W Parks Laurence Collette Michel Praet Ullrich Bethe Eric Van | 2008 | The Lancet2008，，9617： | 1 |
| 20 | Expression of Anti - MfiUerian hormone during normal and pathological gonadal development association with differentiation of Sertoli and granulose cells显示文摘 | Rajpert - DeMeyts E Jorgensen N Graem N | 1999 | J Clin Endocrinol Metab1999，84，： | 1 |
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