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| 1 | B vitamins for stroke prevention显示文摘Supplementation with B vitamins(vitamin B9(folic acid),vitamin B_(12) and vitamin B_(6))lowers blood total homocysteine(tHcy)concentrations by about 25%and reduces the relative risk of stroke overall by about 10%(risk ratio(RR)0.90,95%CI 0.82 to 0.99)compared with placebo.Homocysteine-lowering interventions have no significant effect on myocardial infarction,death from any cause or adverse outcomes.Factors that appear to modify the effect of B vitamins on stroke risk include low folic acid status,high tHcy,high cyanocobalamin dose in patients with impaired renal function and concurrent antiplatelet therapy.In regions with increasing levels or established policies of population folate supplementation,evidence from observational genetic epidemiological studies and randomised controlled clinical trials is concordant in suggesting an absence of benefit from lowering of homocysteine with folic acid for prevention of stroke.Clinical trials indicate that in countries which mandate folic acid fortification of food,folic acid supplementation has no significant effect on reducing stroke risk(RR 1.05,95%CI 0.90 to 1.23).However,in countries without mandatory folic acid food fortification,folic acid supplementation reduces the risk of stroke by about 15%(RR 0.85,95%CI 0.77 to 0.94).Folic acid alone or in combination with minimal cyanocobalamin(≤0.05 mg/day)is associated with an even greater reduction in risk of future stroke by 25%(RR 0.75,95%CI 0.66 to 0.86),whereas the combination of folic acid and a higher dose of cyanocobalamin(≥0.4 mg/day)is not associated with a reduced risk of future stroke(RR 0.95,95%CI 0.86 to 1.05).The lack of benefit of folic acid plus higher doses of cyanocobalamin(≥0.4 mg/day)was observed in trials which all included participants with chronic kidney disease.Because metabolic B_(12)deficiency is very common and usually not diagnosed,future randomised trials of homocysteine-lowering interventions for stroke prevention should probably test a combination of folic acid and methylcobalamin or hydroxocobalamin instead of cyanocobalamin,and perhaps vitamin B_(6). | Graeme J Hankey | 2018 | Stroke & Vascular Neurology2018，3，2： | 7 |
| 2 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 3 | Mechanical thrombectomy with the S olitaire AB device in large intracerebral artery occlusions显示文摘 | John J McCabe Timothy J Phillips Con Phatouros Tejinder Singh David Blacker Graeme J Hankey William McAuliffe | 2012 | Journal of Medical Imaging and Radiation Oncology2012，，2： | 2 |
| 4 | Secondary Prevention of Recurrent Stroke 显示文摘 | Graeme J Hankey | 2005 | Stroke2005，36，： | 1 |
| 5 | A YAC mouse model for Huntington's disease with full-length mutant huntingtin,cyt and selective striatal neurodegeneration oplasmic toxicity, 显示文摘 | Hodgson J Graeme Agopyan Nadia Gutekunst Claire- Anne | 1999 | Neuron1999，23，1： | 1 |
| 6 | Evidence for the adsorption of molecules at special sites located at copper/zinc oxide interfaces (Part 3): Fourier-transform infrared study of methyl formate adsorption on reduced and oxidised Cu/ ZnO/SiO2 catalysts显示文摘 | Graeme J M Colin H R | 1992 | J Chem Soc Faraday Trans1992，88，23： | 1 |
| 7 | Application of partial mutual information variable selection to ANN forecasting of water quality in water distribution systems 显示文摘 | Robert J M Graeme C D Holger R M | 2008 | Environmental Modelling & Software2008，3，8： | 1 |
| 8 | A fast and robust algorithm for Bader decomposition of charge density显示文摘 | Graeme Henkelman Andri Arnaldsson Hannes Jónsson | 2005 | Computational Materials Science2005，，3： | 1 |
| 9 | An in situ high pressure FT-IR study of CO2/H2 interactions with model ZnO/SiO2, Cu/SiO2 and Cu/ZnO/SiO:methanol synthesis catalysts显示文摘 | Graeme J Millar Rochester C H | 1992 | Catalysis Letters1992，，07： | 1 |
| 10 | A polyketide synthase in glycopeptide biosynthesis 显示文摘 | Volker Pfeifer Graeme J N Johannes R | 2001 | J Biol Chem2001，276，38： | 1 |
| 11 | Methanol conversion to hydrocarbons over zeolite catalysts comments on the reaction mechanism for the formation of the first carbon-carbon bond 显示文摘 | Graham J Hutchings Graeme W Watson David J Willock | 1999 | Microporous and Mesoporous Materials1999，29，12： | 1 |
| 12 | An improved genetic algorithm for pipe network optimization显示文摘 | Graeme C Dandy Angus R Simpson Lanurence J Murphy | 1996 | Water Resources Research1996，32，2： | 1 |
| 13 | Influence of synthesis route on the catalytic properties of La1-xSrxMnO3显示文摘 | Millar Graeme J Drennan John | 2000 | Solid State Ionics2000，131，： | 1 |
| 14 | The mechanisms of action of gabapentin and pregablin显示文摘 | Graeme J sills | 2006 | Current Opinion in Pharmacology2006，，1： | 1 |
| 15 | Surgery for primary intracerebral hemorrhage:Is it safe and effective? A systematic review of case seriesand randomized trials 显示文摘 | | 1997 | Stroke1997，28，： | 1 |
| 16 | Incomplete Inhibition of Thromboxane Biosynthesis by Acetylsalicylic Acid: Determinants and Effect on Cardiovascular Risk显示文摘 | John W. Eikelboom Graeme J. Hankey Jim Thom Deepak L. Bhatt P Gabriel Steg Gilles Montalescot S Claiborne Johnston Steven R. Steinhubl Koon-Hou Mak J Donald Easton Christian Hamm Tingfei Hu Keith A.A. Fox Eric J. Topol | 2008 | Circulation2008，，17： | 1 |
| 17 | Identification and detection of Actinobacillus pleuropneumoniae by PCR based on the gene apxⅣA 显示文摘 | Schaller A Steven P D Graeme J E | 2001 | Vet Microbiol2001，79，： | 1 |
| 18 | Metal- lic-covalent interatomic potential for carbon in iron 显示文摘 | Hepburn Derek J and Ackland Graeme J | 2008 | Phys RevB2008，78，1： | 1 |
| 19 | Collection of hydrophobicparticles in the froth phase 显示文摘 | Ata Seher Ahmed Nafis Graeme J Jameson | 2002 | International Journalof Mineral Processing2002，64，23： | 1 |
| 20 | Strategies for adaptive optimization with aggregation constraints using interior-point methods 显示文摘 | Graeme J Kennedy | 2015 | Computers and Structures2015，153，2： | 1 |
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