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	题名	作者	年代	出处	被引量
1	Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.	Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o\|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer	2005	World Journal of Gastroenterology2005，11，44：	2
2	A general method to coat colloidal particles with silica 显示文摘	Graf C Vossen DLJ Imhof A	2003	Langmuir2003，19，17：	1
3	Effect of changing strain paths on forming limit diagram of AL2008-T4显示文摘	Graf A Hosford W	1993	Metal-lurgical Transactions A1993，24，1：	1
4	A dynamic lattice Monte Carlo model of ion transport in inhomogeneous dielectric environments: Method and implementation 显示文摘	Graf P Nitzan A Kumikova M G	2000	J Phys Chem B2000，10，：	1
5	Production and purification of N-terminal half-transferrin in Pichia pastoris显示文摘	STEINLEIN L M GRAF T N IKEDA R A	1995	Protein Expr Purif1995，6，5：	1
6	Uniform flow in a smooth open channel显示文摘	Cardoso A H Graf W H Gust G	1989	Journal of Hydraulic Engineering ASCE1989，27，5：	1
7	Impact of trophblast pene- tration through the basal membrance on the efficacy of drug therapy in tubal pregnancy 显示文摘	KLEIN M GRAF A KISS A	1995	Hum Reprod1995，10，2：	1
8	Anaerobic ammonium oxidation discovered in a denitrifying fluidized bed reactor 显示文摘	Mulder A van de Graf A A Robertson L A	1995	FEMS Microbiol Ecology1995，16，3：	1
9	Physical activity,leisure habits and obesity in first-grade children显示文摘	GRAF C A KOCH B A DORDEL B	2004	Euro-JCPR2004，11，4：	1
10	Statin treatment after onset of sepsis in a murine model improves survival显示文摘	Merx M W Liehn E A Graf J	2005	Circulation2005，112，1：	1
11	Review of mi- cromachined thermopiles for infrared detection显示文摘	GRAF A ARNDT M SAUER M	2007	Meas- urement Science & Technology2007，18，7：	1
12	Clinical predictors for a high risk for the development of diabetes mel- litus in the early puerperium in women with recent gestational diabetes mellitus显示文摘	SCHAEFER GRAF U M BUCHANAN T A XIANG A H	2002	Am J Obstet Gynecol2002，186，4：	1
13	Concerted action of multiple cis-acting sequences is required for Rev dependence of late human immunodeficiency virus type 1 gene expression显示文摘	Graf M Bojak A Deml L	2000	J Virol2000，74，10：	1
14	Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters显示文摘	BERGE K E TIAN H GRAF G A	2000	Sci2000，290，：	1
15	Survival in nephroblastoma treated according to the trial and study SIOP-9/GPOH with respect to relapse and morbidity 显示文摘	Weirichl A Ludwigl R Graf N	2004	Ann Oncol2004，15，5：	1
16	Perioperative fluid management : An analysis of the present situation 显示文摘	Zausig Y A Weigand M A Graf B M	2006	Anaesthesist2006，55，4：	1
17	Caveolins, liquidordered domains and signal transduction 显示文摘	Smart E J Graf G A McNiven M A	1999	Molecular and Cellular Biology1999，19，：	1
18	1 Matrixmetallop roteinases in inflamm a- tory bowel disease-from basic research to clinical significance显示文摘	Rath T Roderfeld M Graf J et a	2009	Zgas- troen tero2009，47，8：	1
19	Impairment of sleep-related memory consolidation in schizophrenia:relevance of sleep spindles?显示文摘	Goder R Graf A Ballhausen F	2015	Sleep Med2015，16，5：	1
20	Effect of changing strain paths on formaaing limit diagrams of A12008- T4显示文摘	GRAF A HOSFORD W F	1993	Metallurgical Materials Transactions1993，24，11：	1

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