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68篇 您的检索式：作者名="Graf O"

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	题名	作者	年代	出处	被引量
1	Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.	Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o\|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer	2005	World Journal of Gastroenterology2005，11，44：	2
2	Serotonin promotes tumor growth in human hepatocellular cancer显示文摘	SOLL C JANG J H RIENER M O MORITZ W WILD P J GRAF R	2010	Hepatology2010，51，：	1
3	Mucormycoses显示文摘	Euckr J Sezer O Graf B	2001	Mycoses2001，44，78：	1
4	GIOVE-A initial signalanalysis显示文摘	Montenbruck O Günther C Graf S	2006	GPS Solution2006，10，2：	1
5	Mitochondrial genome of the moon jelly Aurelia aurita(Cnidaria,Scyphozoa):A linear DNA molecule encoding a putative DNA-dependent DNA polymerase显示文摘	Shao Z Graf S Chaga O Y	2006	Gene2006，381，：	1
6	Malignant insulinoma: permanent hepatic artery embolization of liver metastases-preliminary results 显示文摘	Winkelbauer FW Nierderle B Graf O	1995	Cardiovasc Intervent Radiol1995，18，：	1
7	Anatomic variants of mesenteric veins:depiction with helical CT venography显示文摘	Graf O Boland GW Kaufman JA	1997	AJR Am J Roentgenol1997，168，5：	1
8	Mucormycoses 显示文摘	Eucker J Sezer O Graf B	2001	Mycoses2001，44，8：	1
9	Arterial versus portal venous helical CT for revealing pancreatic adenocrcinoma:con spicuity of tumor and cricical vascular anatomy显示文摘	Boland Gw Warshaw AL	1997	AJR1997，，：	1
10	Follow-up of Palpable circumscribed noncalcified solid breast masses at mammography and US:can biopsy be averted显示文摘	Graf O Helbich TH Fuchsjaeger MH	2004	Radiology2004，233，：	1
11	Determination of optimal time window for liver scanning with CT during arterial portography显示文摘	Graf O Dock WI Lammer J	1994	Radiology1994，190，1：	1
12	Arterial versus portal venous helical CT for revealing pancreatic adenocarcinoma:conspicuity of tumor and critical vascular anatomy显示文摘	Graf O Boland GW Warshaw AL	1997	AJR1997，169，：	1
13	Clinical and functional outcomes of laminoplasty and laminectomy 显示文摘	Hardman J Graf O Kouloumberis PE	2010	Neurol Res2010，32，4：	1
14	Clinical and function- al outcomes of laminoplasty and lamineetomy显示文摘	Hardman J Graf O Kouloumberis PE	2010	Neurol Res2010，32，4：	1
15	Safety assessment of structures in view of fuzzy randomness显示文摘	Bernd M(O)ller Wolfgang Graf Michael Beer	2003	Computers & Structures2003，81，：	1
16	Arterial versus portal venous helical CT for revealing pancreatic adenocarcinoma: conspicuity of tumors and critical vascular anatomy显示文摘	Graf O Boland GW Warshaw AL	1997	AJR1997，169，1：	1
17	Aspergilus galactomannan testing in patients with long-term neutropenia : implications for clinical management显示文摘	Penack O Rempf P Graf B	2008	Ann Oncol2008，19，4：	1
18	Clinical and functional outcomes of laminoplasty and laminectomy显示文摘	Hardman J Graf O Kouloumberis PE		0，，04：	1
19	Aspergillus galactomannan testing in patients with long-term neutropenia:implications for clinical management显示文摘	Penack O Rempf P Graf B	2008	Ann Oncol2008，19，5：	1
20	Arterial versus portal venous helical CT for revealing pancreatic adenocarcinoma:conspicuity of tumor and critical vascular anatomy显示文摘	Graf O Boland GW Warshaw AL	1997	AJR1997，169，：	1

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