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| 1 | Presentation of hepatocellular antigens显示文摘肝是抗原特定的 T 房间回答向有免疫力的忍耐在表明偏爱的一个机关。这清楚地在肝移植的 allogeneic 的拒绝被看见,并且多重另外的现象建议这效果是更一般的。这些向经由门静脉,到几个 hepatotropic 病毒的有免疫力的失败,到疟疾寄生虫的自然肝阶段免疫的缺乏,和癌症的经常的转移介绍给肝的抗原包括忍耐。这里,我们考察 T 房间与 hepatocellular 抗原,如此的相遇在发生的上下文,和行动压制完整的 T 房间回答的机制由从事的机制。当许多机制起一个作用时,我们将主张二个重要过程是限制在上干扰素驾驶的否定反馈抑制的 hepatocellular 抗原,和正式就职跨演讲。到从肠的微生物引起的产品的肝的经常的暴露可以驾驶天生的免疫,为通过这机制的特定的 T 房间回答使本地环境变为相反。不过,向 hepatocellular 抗原的忍耐不是整体的并且在特定的情形下面允许有效免疫和 immunopathology。 | Arash Grakoui Ian Nicholas Crispe | 2016 | Cellular & Molecular Immunology2016，13，3： | 5 |
| 2 | Memory CD8+ T cell differentiation in viral infection: A cell for all seasons显示文摘Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus- specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system. | Henry Radziewicz Luke Uebelhoer Bertram Bengsch Arash Grakoui | 2007 | World Journal of Gastroenterology2007，13，36： | 4 |
| 3 | Transcription of infectious yellow fever RNA from full-length cDNA templates prodduced by in vitro ligation显示文摘 | Rice CM Grakoui A Chambers T J | 1989 | New Biol1989，1，： | 1 |
| 4 | Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs 显示文摘 | RANDALLL G GRAKOUI A RICE CM | 2003 | Proc Nat Acad Sci U S A2003，100，1： | 1 |
| 5 | Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serineprotease responsible for site-specific cleavages in the viral polyprotein 显示文摘 | Chambers TJ Weir RC Grakoui A | 1990 | Proc Natl Acad Sci USA1990，87，： | 1 |
| 6 | HCV persistence and immune evasion in the absence of memory T eell help显示文摘 | GRAKOUI A SHOUKRY NH WOOLLARD DJ | 2003 | Science2003，302，5645： | 1 |
| 7 | The immunological synapse:a molecular machine controlling T cell activation显示文摘 | Grakoui A Bromley SK SumenC | | 0，，9： | 1 |
| 8 | The immunological synapse: a molecular machine controlling T cell activation显示文摘 | Grakoui A Bromley SK Sumen C | 1999 | Science1999，285，5425： | 1 |
| 9 | Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs显示文摘 | RANDALL G GRAKOUI A RICE C M | 2003 | Proc Nat Acad Sci USA2003，100，： | 1 |
| 10 | Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs 显示文摘 | Randall G Grakoui A Rice C M | 2002 | PNAS2002，100，1： | 1 |
| 11 | Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs显示文摘 | Randall G Grakoui A Rice CM | | 0，，： | 1 |
| 12 | Hepatitis C virus: why do we need a vaccine to prevent a curable persistent infection?显示文摘 | Walker CM Grakoui A | 2015 | CUrT Opin Immunol2015，35，： | 1 |
| 13 | Clearance of replicating hepatitis C virus replieon RNAs in cell culture by small interfering RNAs显示文摘 | Grakoui A Rice CM | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 14 | Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transducation and gene regulation kinetics显示文摘 | Marcello T Grakoui A Barba-Spatch G | 2006 | Gastroenterology2006，131，6： | 1 |
| 15 | Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection显示文摘 | Shoukry NA Grakoui A Houghton M | 2003 | J Exp Med2003，197，： | 1 |
| 16 | The immunologicalsynapse:a molecular machine controlling T cell activation显示文摘 | Grakoui A Bromley SK Sumen C | 1999 | Science1999，285，5425： | 1 |
| 17 | The immunological synapse: A molecular machine controlling T cell activation 显示文摘 | Grakoui A Bromley S K Sumen C | 1999 | Science1999，285，： | 1 |
| 18 | The immunological synapse: a molecular machine controlling T cell activation显示文摘 | Bromley S K Sumen C | 1999 | Science1999，285，： | 1 |
| 19 | Charac- terization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites 显示文摘 | GRAKOUI A MCCOURT D WYCHOWSKI C | 1993 | J Virol1993，67，5： | 1 |
| 20 | HCV persistence and immune evasion in the absence of memory T cell help 显示文摘 | Grakoui A Shoukry NH Woollard DJ | 2003 | Science2003，302，5645： | 1 |
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