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| 1 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 2 | Effect of bone loss in anterior shoulder instability显示文摘Anterior shoulder instability with bone loss can be a difficult problem to treat. It usually involves a component of either glenoid deficiency or a Hill-Sachs lesion. Recent data shows that soft tissue procedures alone are typically not adequate to provide stability to the shoulder. As such, numerous surgical procedures have been described to directly address these bony deficits. For glenoid defects, coracoid transfer and iliac crest bone block procedures are popular and effective. For humeral head defects, both remplissage and osteochondral allografts have decreased the rates ofrecurrent instability. Our review provides an overview of current literature addressing these treatment options and others for addressing bone loss complicating anterior glenohumeral instability. | Grant H Garcia Joseph N Liu David M Dines Joshua S Dines | 2015 | World Journal of Orthopedics2015，6，5： | 3 |
| 3 | Gastrointestinal and liver disease in patients with schizophrenia:A narrative review显示文摘Schizophrenia is a severe mental illness which can have a devastating impact onan individual’s quality of life. Comorbidities are high amongst patients and lifeexpectancy is approximately 15 years less than the general population. Despite thewell-known increased mortality, little is known about the impact of gastrointestinaland liver disease on patients with schizophrenia. We aimed to reviewthe literature and to make recommendations regarding future care. Literaturesearches were performed on PubMed to identify studies related to gastrointestinaland liver disease in patients with schizophrenia. High rates of chronic liverdisease were reported, with Non-Alcoholic Fatty Liver Disease being of particularconcern;antipsychotics and metabolic syndrome were contributing factors. Ratesof acute liver failure were low but have been associated with antipsychotic useand paracetamol overdose. Coeliac disease has historically been linked to schizophrenia;however, recent research suggests that a causal link is yet to be proven.Evidence is emerging regarding the relationships between schizophrenia andpeptic ulcer disease, inflammatory bowel disease and irritable bowel syndrome;clinical vigilance regarding these conditions should be high. Patients with schizophreniapoorly engage with bowel cancer screening programmes, leading to latediagnosis and increased mortality. Clozapine induced constipation is a significantissue for many patients and requires close monitoring. There is a significantburden of gastrointestinal and liver disease amongst patients with schizophrenia.Better levels of support from all members of the medical team are essential toensure that appropriate, timely care is provided. | Rebecca K Grant William M Brindle Mhairi C Donnelly Pauline M McConville Thomas G Stroud Lorenzo Bandieri John N Plevris | 2022 | World Journal of Gastroenterology2022，28，38： | 2 |
| 4 | 查看详情显示文摘 | Chen S Cowan C F N Grant P M | | 0，，： | 2 |
| 5 | Carbon-13:naturally occurring nucleoside 显示文摘 | Alan J J Winkely M W Grant D M | 1970 | Proc Nat Acad Sci1970，65，1： | 2 |
| 6 | Toward a knowledge-based theory of the firm显示文摘 | Grant R M | 1996 | Strategic Management Journal1996，17，： | 2 |
| 7 | The resource-based theory of competitive advantage:Implications for strategy formulation显示文摘 | Grant R M | 1991 | California Management Review1991，33，3： | 2 |
| 8 | Effect of zinc on cadmium concentration in tissue of durum wheat 显示文摘 | CHOUDHARY M BAILEY L D GRANT C A | 1994 | Canadian Journal of Plant Science1994，74，： | 1 |
| 9 | Prospering in dynamically-competitive environments:organizational capability as knowledge integration显示文摘 | Grant R M | 1996 | Organization Science1996，7，： | 1 |
| 10 | Quality of life out comes in 599 cancer and non-cancer patients with colostomies显示文摘 | Krouse R Grant M Ferrell B | 2007 | J Surg Res2007，138，1： | 1 |
| 11 | The Terminal Velocity and Frequency of Oscillation of Drops in Pure Systems显示文摘 | EDGE R M GRANT C D | 1971 | Chemical Engineering Science1971，26，7： | 1 |
| 12 | Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells显示文摘 | Grant L R Yao Z J Hedrich C M | 2008 | Genes Immun2008，9，： | 1 |
| 13 | Investigation into the biological stability of collagen/chondroitin-6-sulphate gels and their contraction by fibroblasts and keratinocytes: the effect of crosslinking agents and diamines显示文摘 | Osborne C S Reid W H Grant M H | 1999 | Biomaterials1999，20，3： | 1 |
| 14 | Toward a knowledge-based theory of the firm 显示文摘 | Grant R M | 1996 | Strategic Management Journal1996，17，： | 1 |
| 15 | Fluconazole,a review of pharcodynamic and pharmacokinetic properties,and therapeutic potential in superficial and systemic mycoses显示文摘 | GRANT S M CLISSOLD S P | 1990 | Drugs1990，39，： | 1 |
| 16 | Orthogonal least squares learning algorithm for radiate basis function network显示文摘 | CHEN S COWAN C F N GRANT P M | 1991 | IEEE Transactions on Neural Network1991，2，2： | 1 |
| 17 | Plant responses to potassium deficiencies:a role for potassium transport proteins显示文摘 | ASHLEY M K Grant M Grabov A | 2006 | J Exp Bot2006，57，2： | 1 |
| 18 | The Resource-Based Theory of Competitive Advantage: Implications for Strategy Formation 显示文摘 | GRANT R M | 1991 | California Management Review (Spring)1991，，： | 1 |
| 19 | Multiplex real-time PCR detection of heat-labile and heat-stable toxin genes in enterotoxigenie Escherichiacoli显示文摘 | GRANT M A HU J JINNEMAN K C | 2006 | Food Pmt2006，69，2： | 1 |
| 20 | Pereutaneous tracheostomy: a 6 yr prospective evaluation of the single tapered dilator technique显示文摘 | DEMPSEY G A GRANT C A JONES T M | 2010 | Br J Anaesth2010，105，6： | 1 |
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