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| 1 | 不同改性Hummers法合成氧化石墨(英文)显示文摘通过不同的Hummers法和重铬酸钠氧化法,以商业石墨为原料,合成出不同氧含量和官能团的氧化石墨。采用元素分析、FTIR、XPS、SEM和XRD对氧化石墨进行化学和结构表征。重铬酸钾氧化能得到一种氧含量低的氧化石墨,主要形成羟基和环氧基。Hummers法是更有效的一种氧化方法。使用Na NO3氧化2 h,得到的氧化石墨具有最高的氧含量(>40 wt%),形成C—O和C=O键。SEM和XRD结果表明,在这些条件中,Hummers法合成的氧化石墨的石墨层间距最大。因此,用相同的氧化方法,通过改变反应条件能调控氧化石墨的化学结构。 | Roksana Muzyka Monika Kwoka Lukasz Smedowski Noel Díez Grazyna Gryglewicz | 2017 | 新型炭材料2017，32，1： | 16 |
| 2 | Note on the karyotype and NOR location of Siamese fighting fish Betta splendens (Perciformes, Osphronemidae)显示文摘 | Grazyna F S Fopp B D Jankun M | 2008 | Caryologia2008，61，4： | 1 |
| 3 | The mechanism of neuroprotection by Topiramate in an animal model of epilepsy 显示文摘 | Alexei P Grazyna D Stefan V | 2004 | Epilepsia2004，45，12： | 1 |
| 4 | Application of the catalytic properties of N-methylthiourea to the determination of In(Ⅲ) at low levels by square wave voltam-metry显示文摘 | Agnieszka N W Grazyna D | 2009 | Monatshefte fur Chemie/Chemical Monthly2009，140，12： | 1 |
| 5 | Effect of Dose Rate and Mixtures of Fungicides on Selection for QoI Resistance in Populations of Plasmopara viticola显示文摘 | JEAN-LUC G GRAZYNA J FRANCINE D | 2006 | Pest Manag Sci2006，62，： | 1 |
| 6 | The mechanism of neuroprotection by tipiromate in an animal model of epilepsy显示文摘 | Alexei P Grazyna D Stefan V | 2004 | Epilepsia2004，45，： | 1 |
| 7 | Antidepressants in chronic unpredictable mild atress (CUMS)-induced deficit of fighting behavior显示文摘 | GRAZYNA O ZOFIA D BOZENA K | 2004 | Pol J Pharmacol2004，56，： | 1 |
| 8 | The mechanism of neuroproteotion by Topiramate in an animal model of epilepsy显示文摘 | Grazyna D Stefan V | 2004 | Epilepsin2004，45，12： | 1 |
| 9 | Detection of isolated ceils in the blood and bone marrow of patients with gastric cancer by combined sorting,isolation and determination of MAGE-1,-2 mRNA expression显示文摘 | Rafal S Grazyna D Jaroslaw B | 2008 | Oncology Reprots2008，19，4： | 1 |
| 10 | Mechanisms of nitric-ox- ide-induced increase of free eytosolie Ca2+ concentration in Nicotiana plumbaginifolia cells显示文摘 | Olivier L Cecile C Grazyna D | 2006 | Free Radical Biology and Medicine2006，40，： | 1 |
| 11 | The mechanism of neuroprotection by tipiromate in an animal model of epilepsy 显示文摘 | Alexei P Grazyna D Stefan V | 2004 | Epilepsia2004，45，12： | 1 |
| 12 | Surface activity of cationic surfactants, influence of molecular structure 显示文摘 | GRAZYNA P AGNIESZKA H D KAZIMIERA A W | 2010 | Colloids and Surfaces A :Physicochem Eng Aspects2010，365，： | 1 |
| 13 | Interleukin-17A blockade with secukinumab results in decreased neutrophil infiltration in psoriasis: minimally-invasive measurement by tape stripping显示文摘Psoriasis is a well characterized interleukin (IL)-17A-driven skin disease with neutrophil infiltration and epidermal hyperkeratosis. Several biomarkers, most prominently β-defensin-2 (BD-2), have been identified using local and systemic invasive measurements as responsive markers of IL-17A-driven skin pathology. We sought to determine whether measurements of epidermal proteins by tape stripping could offer a minimally-invasive method to assess treatment responses. We compared the expression of 170 proteins in the epidermis (tape stripping) and dermis (open flow microperfusion) of 8 psoriatic subjects before and after administration of a single dose of subcutaneous (s.c.) anti- IL-17A mAb secukinumab. Proteomic analyses of tape strips revealed a >3-fold decrease in 32 epidermal and inflammatory cell proteins in response to secukinumab. The epidermal proteins with the largest (>10-fold) decreases were: matrix metalloproteinase-8 (MMP-8, 15.68-fold, p<0.05);myeloperoxidase (MPO, 14.72-fold, p<0.005);IL-8 (11.93-fold, p<0.05);MMP-9 (10.81-fold, p<0.005);and IL-1β(10.35-fold, p<0.05). For these proteins, greater-fold protein changes were detected in the epidermis compared to dermis. Immunohistochemical analysis confirmed that neutrophils are the predominant cell type in psoriatic skin lesions that express MPO, MMP-8 and MMP-9, and that secukinumab treatment dramatically decreases neutrophil accumulation. Thus, tape stripping may be used to assess epidermal neutrophils, and protein biomarker responses to anti-IL-17A therapy in psoriasis. | Christian Loesche Frank Kolbinger Marie-Anne Valentin Philip Jarvis Melanie Ceci Grazyna Wieczorek Edward Khokhlovich Irina Koroleva Gerard Bruin Frank Sinner Birgit Aigner Dhavalkumar D Patel | 2016 | Advances in Precision Medicine2016，1，2： | 0 |
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