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| 1 | Efficacy of infliximab in acute severe ulcerative colitis:A single-centre experience显示文摘AIM:To suggest infliximab(IFX) is effective for acute severe ulcerative colitis,from real-life clinical practice.METHODS:All patients receiving IFX for the treatment of acute severe ulcerative colitis in a single centre were included.Data were extracted from clinical records in order to assess response to IFX therapy.The primary endpoint was colectomy-free survival,and secondary outcomes included glucocorticosteroid-free remission and safety,which was evaluated by recording deaths and adverse events.Demographic and clinical characteristics of those who underwent colectomy and those who were colectomy-free,both at discharge from their index admission,and during follow-up after an initial response to IFX were compared.RESULTS:Forty-four patients(16 females,mean age 36 years) received IFX between May 2006 and January 2012 for acute severe ulcerative colitis.The median duration of follow-up post-first infusion was 396 d(interquartile range = 173-828 d).There were 21(47.7%) patients with < 1 year of follow-up,10(22.7%) with 1 years to 2 years of follow-up,and 13(29.5%) with > 2 years of follow-up post-first infusion of IFX.Overall,35(79.5%) responded to IFX,avoiding colectomy during their index admission,29(65.9%) were colectomyfree at last point of follow-up(median follow-up 396 d),and 25(56.8%) were in glucocorticosteroid-free remission at end of follow-up.There was one death from post-operative sepsis,20 d after a single IFX infusion.Colectomy rates were generally lower among those 'bridging' to thiopurine.Of 18 patients 'bridged' to thiopurine therapy,17(94.4%) were colectomyfree,and 15(83.3%) were in glucocorticosteroid-free remission at study end.No predictors of response were identified.CONCLUSION:IFX is effective for acute severe ulcerative colitis in real-life clinical practice.Two-thirds of patients avoided colectomy,and more than 50% were in glucocorticosteroid-free remission. | Stephen J Halpin P John Hamlin Daniel P Gree Lisa Warren Alexander C Ford | 2013 | World Journal of Gastroenterology2013，19，7： | 1 |
| 2 | The first enantiocontrolled synthesis of E, E-conjugated dienes with a fluorine atom in the allylic position 显示文摘 | Gree D M Kermarrec C J M Martelli J T | 1996 | J Org Chem1996，61，6： | 1 |
| 3 | Synthese de cyclopropanes electrophiles chiraux par l'intermediaire de complexes butadiene-fer tricarbonyle optiquement actifs 显示文摘 | A Monpert J Martelli R Gree | 1981 | Tetrahedron Lett1981，22，21： | 1 |
| 4 | C - reactive protein : A clinical marker in community aequired pneumonia显示文摘 | SMITH RP LIPWORTH B J GREE IA | 1995 | Chest1995，108，5： | 1 |
| 5 | Fetal echocardiographic screening for congenital heart diease: the importance of the four - chamber view显示文摘 | Cope AI Pilu G Gree J | 1987 | Am J Obstet Gynecol1987，157，： | 1 |
| 6 | Fetal echocardiographic screening for congenital heart diease:the importance of the four-chamber view显示文摘 | Cope AJ Pilu G Gree J | 1987 | Am J Obstet Gynecol1987，157，3： | 1 |
| 7 | Characterization of 23% efficiency silicon solar cells显示文摘 | Gree N M A Blakers A W Zhao J | 1990 | IEEE Transactions on Electron Devices1990，37，2： | 1 |
| 8 | PWR steam generators 显示文摘 | Gree S J Hetsroni N G | 1995 | International Journal of Multiphase Flow1995，21，： | 1 |
| 9 | Pulmonary embolism and its prophylaxis following the charnley total replacement 显示文摘 | Johnson R Gree JR Charnley J | 2001 | Clin Orthop2001，127，： | 1 |
| 10 | Bone structure and B-cell populations,crippled byobesity,are partially rescued by brief daily exposure tolow-magnitude mechanical signals显示文摘 | M Ete Chan Benjamin J Adler Danielle E Gree | 2012 | The FASEB Journal2012，26，12： | 1 |
| 11 | Estimating Elasticities with the Linear Approximate Almost Ideal Demand System:Some Monte Carlo Results显示文摘 | Alston J M Foster K A Gree R D | 1994 | The Review of Economics and Statistics1994，，： | 1 |
| 12 | Fetal echocardiographic screening for congenital heart diease : the importance of the four - chamber view 显示文摘 | Cope A J Pilu G Gree J | 1987 | Am J Obstet Gynecol1987，157，： | 1 |
| 13 | Pre-industrial and contemporary fluxes of nitrogen through rivers: a global assessment based on typology显示文摘 | Gree P A Vlxtirtismarty C J Meybeck M | 2004 | Biogeochemistry2004，68，1： | 1 |
| 14 | N- methyl-D, L-aspratate stimulates growth hormone release but not luteinizing hormone secretion in the sheep 显示文摘 | Estienne M J Schillo K K Gree M A | 1989 | Life Science1989，44，： | 1 |
| 15 | Application of the intramolecular isomerisation-aldolisation from allylic al- cohols and allylic silyl ethers to the synthesis of indanones and indenones显示文摘 | PETRIGNET J ROISNEL T GREE R | 2007 | Chem Eur J2007，13，26： | 1 |
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