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| 1 | Current position of ALPPS in the surgical landscape of CRLM treatment proposals显示文摘The Authors summarize problems,criticisms but also advantages and indications regarding the recent surgical proposal of associating liver partition and portal vein ligation(PVL)for staged hepatectomy(ALPPS)for the surgical management of colorectal liver metastases.Looking at published data,the technique,when compared with other traditional and well established methods such as PVL/portal vein embolisation(PVE),seems to give real advantages in terms of volumetric gain of future liver remnant.However,major concerns are raised in the literature and some questions remain unanswered,preliminary experiences seem to be promising.The method has been adopted all over the world over the last 2 years,even if oncological long-term results remain unknown,and benefit for patients is questionable.No prospective studies comparing traditional methods(PVE,PVL or classical 2 staged hepatectomy)with ALPPS are available to date.Technical reinterpretations of the original method were also proposed in order to enhance feasability and increase safety of the technique.More data about morbidity and mortality are also expected.The real role of ALPPS is,to date,still to be established.Large clinical studies,even if,for ethical reasons,in well selected cohorts of patients,are expected to better define the indications for this new surgical strategy. | Marcello Donati Gregor A Stavrou Karl J Oldhafer | 2013 | World Journal of Gastroenterology2013，19，39： | 16 |
| 2 | Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting显示文摘AIM: To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS: We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding treated in Canadian hospitals. Risk scores were calculated and used to classify patients based on outcomes. For each outcome, we used χ2 goodness-of-fit tests to assess the degree of calibration, and built receiver operating characteristic curves and calculated the area under the curve (AUC) to evaluate the discriminative ability of the scoring system. RESULTS: For rebleeding, the χ2 goodness-of-fit test indicated an acceptable fit for the model [χ2 (8) = 12.83, P = 0.12]. For surgical procedures [χ2 (8) = 5.3, P = 0.73] and death [χ2 (8) = 3.78, P = 0.88], the tests showed solid correspondence between observed proportions and predicted probabilities. The AUC was 0.59 (95% CI: 0.55-0.62) for the outcome of rebleeding and 0.60 (95% CI: 0.54-0.67) for surgical procedures, representing apoor discriminative ability of the scoring system. For the outcome of death, the AUC was 0.73 (95% CI: 0.69-0.78), indicating an acceptable discriminative ability. CONCLUSION: The Rockall scoring system provides an acceptable tool to predict death, but performs poorly for endpoints of rebleeding and surgical procedures. | Robert A Enns Yves M Gagnon Alan N Barkun David Armstrong Jamie C Gregor Richard N Fedorak RUGBE Investigators Group | 2006 | World Journal of Gastroenterology2006，12，48： | 14 |
| 3 | Genetic testing in congenital heart disease:A clinical approach显示文摘Congenital heart disease(CHD) is the most common type of birth defect. Traditionally, a polygenic model defined by the interaction of multiple genes and environmental factors was hypothesized to account for different forms of CHD. It is now understood that the contribution of genetics to CHD extends beyond a single unified paradigm. For example, monogenic models and chromosomal abnormalities have been associated with various syndromic and non-syndromic forms of CHD. In such instances, genetic investigation and testing may potentially play an important role in clinical care. A family tree with a detailed phenotypic description serves as the initial screening tool to identify potentially inherited defects and to guide further genetic investigation. The selection of a genetic test is contingent upon the particular diagnostic hypothesis generated by clinical examination. Genetic investigation in CHD may carry the potential to improve prognosis by yielding valuable information with regards to personalized medical care, confidence in the clinical diagnosis, and/or targeted patient followup. Moreover, genetic assessment may serve as a tool to predict recurrence risk, define the pattern of inheritance within a family, and evaluate the need for further family screening. In some circumstances, prenatal or preimplantation genetic screening could identify fetuses or embryos at high risk for CHD. Although genetics may appear to constitute a highly specialized sector of cardiology, basic knowledge regarding inheritance patterns, recurrence risks, and available screening and diagnostic tools, including their strengths and limitations, could assist the treating physician in providing sound counsel. | Marie A Chaix Gregor Andelfinger Paul Khairy | 2016 | World Journal of Cardiology2016，8，2： | 8 |
| 4 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 5 | Resonance-enhanced multi-octave supercontinuum generation in antiresonant hollow-core fibers显示文摘Ultrafast supercontinuum generation in gas-filled waveguides is an enabling technology for many intriguing applications ranging from attosecond metrology towards biophotonics,with the amount of spectral broadening crucially depending on the pulse dispersion of the propagating mode.In this study,we show that structural resonances in a gas-filled antiresonant hollow core optical fiber provide an additional degree of freedom in dispersion engineering,which enables the generation of more than three octaves of broadband light that ranges from deep UV wavelengths to near infrared.Our observation relies on the introduction of a geometric-induced resonance in the spectral vicinity of the ultrafast pump laser,outperforming gas dispersion and yielding a unique dispersion profile independent of core size,which is highly relevant for scaling input powers.Using a krypton-filled fiber,we observe spectral broadening from 200 nm to 1.7μm at an output energy of B 23μJ within a single optical mode across the entire spectral bandwidth.Simulations show that the frequency generation results from an accelerated fission process of solitonlike waveforms in a non-adiabatic dispersion regime associated with the emission of multiple phase-matched Cherenkov radiations on both sides of the resonance.This effect,along with the dispersion tuning and scaling capabilities of the fiber geometry,enables coherent ultra-broadband and high-energy sources,which range from the UV to the mid‐infrared spectral range. | Rudrakant Sollapur Daniil Kartashov Michael Zürch Andreas Hoffmann Teodora Grigorova Gregor Sauer Alexander Hartung Anka Schwuchow Joerg Bierlich Jens Kobelke Mario Chemnitz Markus A Schmidt Christian Spielmann | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 6 | Stability and nuclear dynamics of the bicoid mor- phogen gradient显示文摘 | GREGOR T WIESCHAUS E F MCGREGOR A P | 2007 | Ce112007，130，： | 1 |
| 7 | SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors显示文摘 | Gregoric P Sijacki A Stankovic S | | 0，，98： | 1 |
| 8 | SIRS Score on Admission and Initial Concentration of IL-6 as Severe Acute Pancreatitis Outcome Pre- dictors 显示文摘 | Gregoric P Sijacki A Stankovic S | 2010 | Hepatogastroenterology2010，57，98： | 1 |
| 9 | Randomized trial of alternating versus sequential radiotherapy/chemotherapy in limited-disease patients with small-cell lung cancer:A European Organisation for Research and Treatment of Cancer Lung Cancer Cooperative Group study显示文摘 | Gregor A Drings P Burghouts J | 1997 | J Clin Oncol1997，15，8： | 1 |
| 10 | The historical residue trend of PCBs in the Agassiz Ice Cap, Ellesmere Island, Canada显示文摘 | Gregor D J Peters A J Teixeira C | 1995 | The Science of The Environment1995，，： | 1 |
| 11 | Lymph node metastases from well differentiated thyroid cancer显示文摘 | Mc Gregor GI Luoma A Jackson SM | 1985 | Am J Surg1985，149，5： | 1 |
| 12 | Freshwater phytoplankton quantification by chlorophyll a:a comparative study of in vitro,in vivo and in situ methods显示文摘 | Gregor J Mar(s)(a)lek B | 2004 | Water Research2004，38，： | 1 |
| 13 | The recent depositional trend of polycyclic aromatic hydrocarbons and elemental carbon to the Agassiz Ice Cap, Ellesmere Island, Canada显示文摘 | Peters A J Gregor D J Teixeira C F | 1995 | The Science of the Total Environment1995，，： | 1 |
| 14 | Feasibility of Video Capsule Endoscopy in the Management of Children With Peutz-Jeghers Syndrome: A Blinded Comparison With Barium Enterography for the Detection of Small Bowel Polyps显示文摘 | Aymer Postgate Warren Hyer Robin Phillips Arun Gupta David Burling Clive Bartram Michelle Marshall Stuart Taylor Gregor Brown Gill Schofield Paul Bassett Christine Spray Aine Fitzpatrick Chris Fraser A Latchford | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 1 |
| 15 | Worsted cashmere top and yarns blended with low or high curvature superfine merino wool 显示文摘 | GREGOR Mc BRUCE A | 2007 | Textile Research Journal2007，77，12： | 1 |
| 16 | Test anxiety and the hierarchical model of approach and avoidance achievement motivation显示文摘 | Elliot A J Mc Gregor H A | 1999 | Journal of Personality and social Psychology1999，76，4： | 1 |
| 17 | Coordination of actuated arterial traffic signal systems显示文摘 | Jovanis P · P Gregor J · A | 1986 | Journal of Transpor- tation Engineering1986，112，4： | 1 |
| 18 | Twenty-four-hour ambulatory blood pressure monitoring in infants and toddlers显示文摘 | Varda N M Gregoric A | 2005 | Pediatr Nephrol2005，20，6： | 1 |
| 19 | SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors显示文摘 | Gregoric P Sijacki A Stankovic S | 2011 | Hepatogastroenterology2011，58，105： | 1 |
| 20 | A medical re- search council randomized trial in patients with primary cerebral non-Hodgkin lymphoma: cerebral radiotherapy with and without cyclophosphamide, doxorubicin, vin- cristine, and prednisone chemotherapy显示文摘 | Mead GM Bleehen NM Gregor A | 2000 | Cancer2000，89，6： | 1 |
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