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| 1 | Pathogenesis of occult chronic hepatitis B virus infection显示文摘Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological patterns.Occult HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene expression.OBI is an entity with world-wide diffusion.The failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this'occult'HBV infection;although the mechanisms responsible for suppression of HBV are not well understood.The majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV infection.Much evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma. | Rocio Aller de la Fuente María L Gutiérrez Javier Garcia-Samaniego Conrado Fernández-Rodriguez Jose Luis Lledó Gregorio Castellano | 2011 | World Journal of Gastroenterology2011，17，12： | 12 |
| 2 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 3 | Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer显示文摘Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic chemotherapy.FCH constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological findings.Here,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced immunosuppression.This is the first reported case in the literature of FCH after conventional chemotherapy for a solid tumor.In addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed. | Jaime Ceballos-Viro José M López-Picazo José L Pérez-Gracia Jesús J Sola Gregorio Aisa Ignacio Gil-Bazo | 2009 | World Journal of Gastroenterology2009，15，18： | 3 |
| 4 | Vibrant soundbridge in congenital osseous atresia: multicenter study of' 12 patients with osseous atrcsia 显示文摘 | Zemotti M E Arauz S L Di Gregorio M F | 2013 | Acta Otolaryngol2013，133，6： | 1 |
| 5 | Evaluation of heavy metal availability prior to an in situ soil phytoremediation program显示文摘 | Gregorio G Andrea L Z Angel F 2005 | 2005 | Biodegradation2005，16，2： | 1 |
| 6 | Progress in breeding for salinity tolerance and associated abiotie stress in rice 显示文摘 | Gregorio G B Senadhira D Mendoza R D Manigbas R D Roxas N L Guerta C Q | 2002 | Field Crops Research2002，76，2： | 1 |
| 7 | Characterization of Well Faceted Palladium Nano- particles Supported on Alumina by Transmission E- lectron Microscopy and FT-IR Spectroscopy of CO Adsorption显示文摘 | D GREGORIO F BISSON L ARMAROLI T | 2009 | Appl Catal A: General2009，352，12： | 1 |
| 8 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 9 | Desenvolvimento Das Gonadas de Dermatobia hominis(Diptera:Cuterebridae)显示文摘 | LELLO E D GREGORIO E A TOLEDO L A | 1985 | Mem Inst Oswaldo Cruz1985，80，2： | 1 |
| 10 | Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinomas 显示文摘 | Fante R Roncucci L Di Gregorio O | 1996 | Cancer1996，77，： | 1 |
| 11 | Molecular diagnosis of infective endocarditis by re- al-time broad-range polymerase chain reaction (PCR) and sequencing directly from heart valve tissue 显示文摘 | Marin M Mufioz P Sdnchez M del Rosal M Alcal6 L Rodrlguez-Cr6ixems M Bouza E Group for the Manage- ment of Infective Endocarditis of the Gregorio Marafi6n Hospital | 2007 | Medicine2007，86，4： | 1 |
| 12 | Organizational Learning Dynamics in the Software Publishing Industry显示文摘 | Pedro L Gregorio M Jose E N | 2008 | International Journal of Technology Management2008，41，12： | 1 |
| 13 | Association between cigarette smoking and FHIT gene alteration in lung cancer显示文摘 | Sozzi G Sard L De Gregorio L | 1997 | Cancer Res1997，57，： | 1 |
| 14 | K-ras and p53 mutation in human eolorectal aberrant crypt foci显示文摘 | Losi Roncucci L Gregorio CD | 1996 | J Pathol1996，17，8： | 1 |
| 15 | Elevated antinuclear antibodies and altered anti-Epstein-Barr virus immune responses 显示文摘 | Cuomo L Cirone M Gregorio AO | 2014 | Virus Res2014，195，2： | 1 |
| 16 | Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinoma显示文摘 | Roncucci L Di Gregorio C et at | 1996 | Cancer1996，77，10： | 1 |
| 17 | IL-7 administration alters the CD4:CD8 ratio,increases T cell numbers,and increases T cell function in the absence of activation显示文摘 | Geiselhart L A Humphries C A Gregorio T A | 2001 | J Immunol2001，166，： | 1 |
| 18 | Parametric land cover and land-use classifications as tools for environmental change detection 显示文摘 | JANSEN L J M GREGORIO A DI | 2002 | Agricuhure Ecosystems & Environ- ment2002，91，： | 1 |
| 19 | The Latin American population in Spain and organ donation. Attitude toward deceased organ donation and organ donation rates显示文摘 | Antonio Ríos Ana I. López‐Navas Juan C. Navalón Laura Martínez‐Alarcón Marco A. Ayala‐García María J. Sebastián‐Ruiz Francisco Moya‐Faz Gregorio Garrido Pablo Ramirez Pascual Parrilla | 2015 | Transpl Int2015，，4： | 1 |
| 20 | Parametric land cover and land use classifications as tools for environmental change detection显示文摘 | Jansen L J M Gregorio A D | 2002 | Agriculture Ecosystems and Environment2002，91，1： | 1 |
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