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| 1 | Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer显示文摘Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic chemotherapy.FCH constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological findings.Here,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced immunosuppression.This is the first reported case in the literature of FCH after conventional chemotherapy for a solid tumor.In addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed. | Jaime Ceballos-Viro José M López-Picazo José L Pérez-Gracia Jesús J Sola Gregorio Aisa Ignacio Gil-Bazo | 2009 | World Journal of Gastroenterology2009，15，18： | 3 |
| 2 | Resveratrol attenuates metabolic,sperm,and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates显示文摘High-fat diets affect male reproduction and sexual function.Therefore,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria diet.Male Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)groups.At 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 months.Animals were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further analysis.Data were analyzed by one-way ANOVA,and P<0.05 was considered statistically significant.The CAF diet promoted hyperglycemia(P<0.0001),and treatment with resveratrol reversed this condition(P<0.0001).The CAF diet reduced sperm viability and motility,while resveratrol improved these parameters(F<0.05).Regarding testicular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group(P=0.0007).Spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C group.However,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group(P=0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis. | Fabiana A de Oliveira Waldemar S Costa Francisco J B Sampaio Bianca M Gregorio | 2019 | Asian Journal of Andrology2019，21，2： | 2 |
| 3 | Does Nonalcoholic Fatty Liver Disease Predispose Patients to Hepatocellular Carcinoma in the Absence of Cirrhosis?显示文摘 | Guzman Grace Brunt Elizabeth M Petrovic Lydia M Chejfec Gregorio Layden Thomas J Cotler Scott J | 2008 | Archives of Pathology & Laboratory Medicine2008，，11： | 2 |
| 4 | Effects of S 21403 on hormone secretion from isolated rat pancreas at different glucose concentrations显示文摘 | GREGORIO F AMBROSI F BOEMI M | 2002 | Eur J Pharmacol2002，456，13： | 1 |
| 5 | Effect of crystalline phase, ori- entation and temperature on the dielectric properties of poly (vinylidene fluoride) (PVDF) 显示文摘 | Gregorio R Ueno E M | 1999 | J Appl Polym Sci1999，34，： | 1 |
| 6 | Vibrant soundbridge in congenital osseous atresia: multicenter study of' 12 patients with osseous atrcsia 显示文摘 | Zemotti M E Arauz S L Di Gregorio M F | 2013 | Acta Otolaryngol2013，133，6： | 1 |
| 7 | The role of laparoscoplc my- omectomy in women of reproductive age显示文摘 | Di Gregorio A Maccario S RaspoUini M | 2002 | Reproductive Biomedicine On- line2002，，： | 1 |
| 8 | Parametric land cover and land-use classifications as tools for environmental change detection显示文摘 | Louisa J M Jansen Antonio Di Gregorio | 2002 | Agriculture Ecosystems and Environment2002，91，： | 1 |
| 9 | Development and validation of an analytical method for the determina- tion of arsenic, cadmium and lead content in powdered infant formula by means of quadrupole Inductively Cou- pled Plasma Mass Spectrometry 显示文摘 | Sorbo A Turco A C Di Gregorio M | 2014 | Food Control2014，44，： | 1 |
| 10 | International new ventures:the cross-border nexus of individuals and opportunities显示文摘 | Gregorio D D Musteen M Thomas D E | | 0，，02： | 1 |
| 11 | Flavonoids changes in fresh - cut onions during storage indifferent packaging systems 显示文摘 | Perez - Gregorio M R Garcia- Falcon M S Simal- GandaraJ | 2011 | Food Chemistry2011，124，2： | 1 |
| 12 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 13 | Acute colorectal obstruction:treatment with self-expandable metallic stents before scheduled surgery:results of a multicenter study显示文摘 | Mainar A De Gregorio M A Tejero E | 1999 | Radiology1999，210，1： | 1 |
| 14 | Parametric land cover and land-use classifications as tools for environmental change detection显示文摘 | Louisa J M Jansen Antonio Di Gregorio | 2002 | Agriculture Ecosystems &Environment2002，91，： | 1 |
| 15 | Staging and survival of colorectal cancer:are we making progress显示文摘 | Ponzde Leon M Benatti P Di Gregorio C | 2000 | Dig Liv Dis2000，32，： | 1 |
| 16 | Molecular diagnosis of infective endocarditis by re- al-time broad-range polymerase chain reaction (PCR) and sequencing directly from heart valve tissue 显示文摘 | Marin M Mufioz P Sdnchez M del Rosal M Alcal6 L Rodrlguez-Cr6ixems M Bouza E Group for the Manage- ment of Infective Endocarditis of the Gregorio Marafi6n Hospital | 2007 | Medicine2007，86，4： | 1 |
| 17 | Lonidamine and related compounds 显示文摘 | Silvestrini B Palazzo G De Gregorio M | 1984 | Prog Med Chem1984，21，： | 1 |
| 18 | Effect of crystallization temper- ature on the crystalline phase content and morphology of poly(vinylidene fluoride)显示文摘 | Gregorio R Cestari M | 1994 | J Polym Sci Part B: Polymer Physics1994，32，： | 1 |
| 19 | Organizational Learning Dynamics in the Software Publishing Industry显示文摘 | Pedro L Gregorio M Jose E N | 2008 | International Journal of Technology Management2008，41，12： | 1 |
| 20 | Defaunating capacity of tropical fodder trees: Effects of polyethylene glycol and its relationship to in vitro gas production 显示文摘 | Gregorio E M B Carlos A S C | 2005 | Animal Feed Science and Technology2005，123，1： | 1 |
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