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| 1 | Value of two-phase dynamic multidetector computed tomography in differential diagnosis of post-inflammatory strictures from esophageal cancer显示文摘AIM: To characterize the computed tomography(CT) findings in patients with post-inflammatory esophageal strictures(corrosive and peptic) and reveal the optimal scanning phase protocols for distinguishing postinflammatory esophageal stricture and esophageal cancer.METHODS: Sixty-five patients with esophageal strictures of different etiology were included in this study: 24 patients with 27 histopathologically confirmed corrosive strictures, 10 patients with 12 peptic strictures and 31 patients with esophageal cancer were evaluated with a two-phase dynamic contrast-enhanced MDCT. Arterial and venous phases at 10 and 35 s after the attenuation of 200 HU were obtained at the descending aorta, with a delayed phase at 6-8 min after the start of injection of contrast media. For qualitative analysis, CT scans of benign strictures were reviewed for the presence/absence of the following features: 'target sign', luminal mass, homogeneity of contrast medium uptake, concentric wall thickening, conically shapedsuprastenotic dilatation, smooth boundaries of stenosis and smooth mucous membrane at the transition to stenosis, which were compared with a control group of 31 patients who had esophageal cancer. The quantitative analysis included densitometric parameter acquisition using regions-of-interest measurement of the zone of stenosis and normal esophageal wall and the difference between those measurements(ΔCT) at all phases of bolus contrast enhancement. Esophageal wall thickening, length of esophageal wall thickening and size of the regional lymph nodes were also evaluated. RESULTS: The presence of a concentric esophageal wall, conically shaped suprastenotic dilatation, smooth upper and lower boundaries, 'target sign' and smooth mucous membrane at the transition to stenosis were suggestive of a benign cause, with sensitivities of 92.31%, 87.17%, 94.87%, 76.92% and 82.05%, respectively, and specificities of 70.96%, 89.66%, 80.65%, 96.77% and 93.55%, respectively. The features that were most suggestive of a malignant cause were eccentric esophageal wall thickening, tuberous upper and lower boundaries of stenosis, absence of mucous membrane visualization, rupture of the mucous membrane at the upper boundary of stenosis, cup-shaped suprastenotic dilatation, luminal mass and enlarged regional lymph nodes with specificities of 92.31% 94.87%, 67.86%, 100%, 97.44%, 94.87% and 82.86%, respectively and sensitivities of 70.97%, 80.65%, 96.77%, 80.65%, 54.84%, 87.10% and 60%, respectively. The highest tumor attenuation occurred in the arterial phase(mean attenuation 74.13 ± 17.42 HU), and the mean attenuation difference between the tumor and the normal esophageal wall(mean ΔCT) in the arterial phase was 23.86 ± 19.31 HU. Here, 11.5 HU of ΔCT in the arterial phase was the cut-off value used to differentiate esophageal cancer from post-inflammatory stricture(P = 0.000). The highest attenuation of postinflammatory strictures occurred in the delayed phase(mean attenuation 71.66 ± 14.28 HU), and the mean ΔCT in delayed phase was 34.03 ± 15.94 HU. Here, 18.5 HU of ΔCT in delayed phase was the cut-off value used to differentiate post-inflammatory stricture from esophageal cancer(P < 0.0001).CONCLUSION: The described imaging findings reveal high diagnostic significance in the differentiation of benign strictures from esophageal cancer. | Grigory G Karmazanovsky Svetlana A Buryakina Evgeny V Kondratiev Qin Yang Dmitry V Ruchkin Dmitry V Kalinin | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 2 | RGDS peptides immobilized on titanium alloy stimulatebone cell attachment, differentiation and conferresistance to apoptosis显示文摘 | SECCHI A G GRIGORIOU V SHAPIRO IM | 2007 | J Biomed Mater Res A2007，83，3： | 1 |
| 3 | RGDS peptides immobilized on titanium alloy stimulate bone cell attachment,differentiation and confer resistance to apoptosis显示文摘 | Secchi AG Grigoriou V Shapiro IM | 2007 | J Biomed Mater Res A2007，83，3： | 1 |
| 4 | Perioperatlve Acupunct - ure and Related Techniques 显示文摘 | Grigory V Chemyak MD Daniel | 2005 | Anesthesology2005，102，5： | 1 |
| 5 | Real time morphing wing op-timization validation using wind-tunnel tests显示文摘 | Popov A V Grigorie L T Botez R | 2010 | Journal ofAircraft2010，47，4： | 1 |
| 6 | Phase Synchronization of Chaotic Oscillators by External Driving显示文摘 | Arkady S P Michael G R Grigory V O | 1997 | Physica D : Nonlinear Phenomena1997，104，34： | 1 |
| 7 | High-intensity microwave wood modification for increasing permeability显示文摘 | GRIGORY T PETER V | 2009 | Forest Products Journal2009，59，4： | 1 |
| 8 | RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis显示文摘 | Secchi AG Grigoriou V Shapiro IM | 2007 | J Biomed Mater Res A2007，83，3： | 1 |
| 9 | Corticosteroid treatment does not improve the results of intrauterine insemination in male subfertility caused by antisperm antibodies显示文摘 | Grigoriou O Konidaris S Antonaki V | 1996 | Eur J Obstet Gynecol Reprod Biol1996，65，2： | 1 |
| 10 | Apoptosis and survival of osteoblast- like cell are regulated by surface attachment 显示文摘 | Grigoriou V Shiro IM Cavalcanti-Adam EA | 2005 | J Biol Chem2005，，280： | 1 |
| 11 | Fibronectin plasma levels in gynecological cancers 显示文摘 | GRAMMATIKAKIS I E BOTSIS D C GRIGORIOU O V | 2010 | J BUON2010，15，1： | 1 |
| 12 | Regression of endometrial hyperplasia after treatment with the gonadotrophin releasing hormone analogue triptorelin:a prospective study显示文摘 | Grigoris G Tsalikis T Tzioufa V | 1999 | Human Reproduction1999，14，： | 1 |
| 13 | RGDS peptides immobilized on titanium alloy stimulate bone cel attachment,differentiation and confer resistance to apoptosis显示文摘 | Secchi AG Grigoriou V Shapiro IM | | 0，，03： | 1 |
| 14 | Microwave modification of Ra- diata pine railway sleepers for preservative treatment 显示文摘 | Peter V Grigory T Jeff H | 2011 | European Journal of Wood and Wood Products2011，69，2： | 1 |
| 15 | Modeling and testing of a morphing wing in open-loop architecture 显示文摘 | POPOV A V GRIGORIE T L BOTEZ R M | 2010 | Journal of Aircraft2010，47，3： | 1 |
| 16 | Alteration of opioid peptide concentrations in the rat pituitary following surrivable closed head injury显示文摘 | Grigoriants O O Prabdenkova S V Andersen B J | 1995 | Neurochem Res1995，20，： | 1 |
| 17 | Crohn’s disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants显示文摘AIM: To assess the trends in the incidence of inflammatory bowel disease (IBD) over 23 years in the same area and to identify genetic factors related to incidence evolution. METHODS: Patients with IBD arising from North- western Greece were systematically recorded through the 1983-2005 period. Trends in disease incidence and genetic patterns related to CARD15 variants were documented and correlated. RESULTS: A total of 447 patients with IBD were recorded (23.5% Crohn’s disease, 72.7% Ulcerative colitis and 3.8% indeterminate colitis). Mean annual incidence rates of CD and UC were 0.9/100 000 (95% CI 0.1-1.7) and 2.7/100 000 (95% CI 1.7-4.1) inhabitants, respectively. There was a statistically significant increase of CD incidence (P < 0.01) during the study period, in contrast to the UC incidence. There were no statistical differences in CARD15 variants over the study period. CONCLUSION: The incidence of CD in North-western Greece has risen disproportionately to that of UC in the 21st century. This is not related to alterations of genetic background though. | Michael Economou Grigoris Filis Zoi Tsianou John Alamanos Antonios Kogevinas Kostas Masalas Anna Petrou Epameinondas V Tsianos | 2007 | World Journal of Gastroenterology2007，13，38： | 1 |
| 18 | RGDS Peptides Immobilized on Titanium Alloy Stimulate Bone Cell Attachment, Differentiation and Confer Resistance to Apoptosis显示文摘 | Seochi A G Grigoriou V Shapiro I M | 2007 | Journal of Biomedical Materials Research Part A2007，83，3： | 1 |
| 19 | Synthesis and characterisation of hexagonal molybdenum nitrides 显示文摘 | Alexey Y G Lorenz K Grigori V V | 2006 | J Solid State Chem2006，，179： | 1 |
| 20 | Alteration of opioid pe ptide concentrations in the rat pituitary following survivable closed head injur y显示文摘 | PRAVDENKOVA S V ANDERSEN B J | 1995 | Neurochem Res1995，20，7： | 1 |
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