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| 1 | Endoscopic features of early-stage signet-ring-cell carcinoma of the stomach显示文摘AIM: To identify the features of early signet ring cell gastric carcinoma using magnification endoscopy with narrow band imaging(NBI).METHODS: A retrospective review was conducted of 12 cases of early signet ring cell gastric carcinoma who underwent treatment in a single institution between January 2009 and April 2013. All patients had magnification endoscopy with NBI and indigo carmine contrast to closely examine the mucosal architecture, including the microvasculature and arrangement of gastric pits. Histologic examination of the final endoscopic submucosal dissection or gastrectomy specimen was performed and compared with the endoscopic findings to identify patterns specific to signet ring cell carcinoma.RESULTS: Twelve patients with early signet ring cell gastric carcinoma were identified; 75% were male, and average age was 61 years. Most of the lesions were stage T1a(83%), while the remainder were T1b(17%). The mean lesion size was 1.4 cm2. On standard endoscopy, all 12 patients had a pale, flat lesion without any evidence of mucosal abnormality such as ulceration, elevation, or depression. On magnification endoscopywith NBI, all of the patients had irregularities in the glands and microvasculature consistent with early gastric cancer. In addition, all 12 patients exhibited the 'stretch sign', an elongation or expansion of the architectural structure. Histologic examination of the resected specimens demonstrated an expanded and edematous mucosal layer infiltrated with tumor cells.CONCLUSION: The 'stretch sign' appears to be specific for signet ring cell carcinoma and may aid in the early diagnosis and treatment of this aggressive pathology. | Chainarong Phalanusitthepha Kevin L Grimes Haruo Ikeda Hiroki Sato Chiaki Sato Chananya Hokierti Haruhiro Inoue | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 8 |
| 2 | Measurements of transpiration from savannah shrubs using sap flow gauges显示文摘 | ALLEN S J GRIME V L | 1995 | Agri and For Meter1995，75，： | 2 |
| 3 | Measurements of transpiration from savannah shrubs using sap flow gauges 显示文摘 | Allen S J Grime V L | 1995 | Agri and For Meter1995，75，： | 1 |
| 4 | Physicalactivity and self-reported symptoms of insomnia, restlesslegs syndrome,and depression:the comprehensive dialysisstudy显示文摘 | ANAND S JOHANSEN K L GRIMES B | 2013 | Hemodial Int2013，17，1： | 1 |
| 5 | Influence of engineered titaniananotubular surfaces on bone cells显示文摘 | Popat KC Leoni L Grimes CA | | 0，，21： | 1 |
| 6 | Influence of ertgineered titania nanotubular surfaces on bone cells 显示文摘 | Popat KC Leoni L Grimes CA | 2007 | Biomaterials2007，28，21： | 1 |
| 7 | Education for contraceptive use by women after childbitth显示文摘 | Lopez L M Hiller J E Grimes D A | 2012 | Cochrane Database Syst Rev2012，15，8： | 1 |
| 8 | Radiation olerance of complex oxides 显示文摘 | Sickafus K E Minervini L Grimes R W | 2000 | Science2000，289，： | 1 |
| 9 | Nonstoichiometry in A2B2O7 pyrochlores 显示文摘 | Stanek C R Minervini L Grimes R W | 2002 | Journal of American Ceramic society2002，85，11： | 1 |
| 10 | Reducing publication bias of prospective clinical trials through trial registration 显示文摘 | Abaid L N Grimes D A Schulz K F | 2007 | Contraception2007，76，5： | 1 |
| 11 | Modeling of femtosecond laser-induced non-equilibrium deformation in metal films显示文摘 | Chen J K Beraun J E Grimes L E | 2002 | Int J Solids Struct2002，39，： | 1 |
| 12 | Including the heat storage term in sap flow measurements with the stem heat balance method显示文摘 | Grime V L Morison J I L Simmonds L P | 1995 | Agriculture and Forest Meteorology1995，74，12： | 1 |
| 13 | Including the heat storage term in sap flow measurements with the stem heat balance method显示文摘 | GRIMES V L MORRISON J I L SIMMONDS L P | 1995 | A gric For Meteorol1995，74，： | 1 |
| 14 | The impact of muhifocused interventions on sharps injury rates at an acute-cere hospital显示文摘 | Gershon RR Pearse L Grimes M | 1999 | Infect Control Hosp Epidemio1999，20，12： | 1 |
| 15 | A game theory framework for cooperative management of refillable and disposable bottle life cycles 显示文摘 | GRIMES H G SEAGER T P THEIST L | 2007 | Journal of Cleaner Production2007，15，17： | 1 |
| 16 | Including the heat storage term in sap flow measurements with the stem heat bal- ance method显示文摘 | Grime V L Morison J I L Simmonds L P | 1995 | Agriculture and Forest Meteorology1995，74，： | 1 |
| 17 | Hessian eigenmaps: Locally linear embedding techniques for high-dimensional data 显示文摘 | Donoho D L Grimes C | 2003 | Proc of the National Academy of Sciences of USA2003，100，10： | 1 |
| 18 | Asset Pricing with Loss Aversion显示文摘 | Grime L Semmler W | 2008 | Journal of Economic Dynamic and Control2008，，32： | 1 |
| 19 | Including the heat storage term in sap flow measurements with the stem heat balance method 显示文摘 | GRIMES V L MORRISON J I L SIMMONDS L P | 1995 | Agric For Meteorol1995，74，12： | 1 |
| 20 | A trade-off betweenscale and precision in resource foraging 显示文摘 | Campbell B D Grime J P Mackey J M L | 1991 | Oecologia1991，87，： | 1 |
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