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| 1 | 一项评价银屑病严重程度的3种量表(银屑病面积和严重性指数、医师全面评估指标和点阵系统医师)的评定者之间和之内可靠性的研究显示文摘Background: There is a lack of consensus as to the best way of monitoring psoriasis severity in clinical trials. The Psoriasis Area and Severity Index (PASI) is the most frequently used system and the Physician’s Global Assessment (PGA) is also often used. However, both instruments have some drawbacks and neither has been fully evaluated in terms of ‘validity’and ‘reliability’as a psoriasis rating scale. The Lattice System Physician’s Global Assessment (LS-PGA) scale has recently been developed to address some disadvantages of the PASI and PGA. Objectives: To evaluate the inter-rater and intra rater reliability of the PASI, PGA and LS-PGA. Methods: On the day before the study, 14 dermatologists (raters), with varied experience of assessing psoriasis, received detailed training (2.5 h) on use of the scales. On the study day, each rater evaluated 16 adults with chronic plaque psoriasis in the morning and again in the afternoon. Raters were randomly assigned to assess subjects using the scales in a specific sequence, either PGA, LS-PGA, PASI or PGA, PASI, LS-PGA. Each rater used one sequence in the morning and the other in the afternoon. The primary endpoint was the inter-rater and intrarater reliability as determined by intraclass correlation coefficients (ICCs). Results: All three scales demonstrated ‘substantial’(a priori defined as ICC > 80%) intrarater reliability. The inter-rater reliability for each of the PASI and LS-PGA was also ‘substantial’and for the PGA was ‘moderate’(ICC 75%). Conclusions: Each one of the three scales provided reproducible psoriasis severity assessments. In terms of both intrarater and inter-rater reliability values, the three scales can be ranked from highest to lowest as follows: PASI, LS-PGA and PGA. | Berth-Jones J. Grotzinger K. Rainville C. 周少娜 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，，12： | 8 |
| 2 | Controls on development and diversity of Early Archean stromatolites显示文摘 | ALLWOOD A C GROTZINGER J P KNOLL A H | 2009 | Proceedings of the Natural Academy of Sciences2009，106，： | 1 |
| 3 | Deposition, exhumation, and paleoclimate of an ancient lake deposit, Gale crater, Mars 显示文摘 | GROTZINGER J P GUPTA S MALIN M C | 2015 | Science2015，350，6257： | 1 |
| 4 | A positive geno-type-phenotype correlation in a large cohort of patientswith Pseudohypoparathyroidism Type Ia and Pseudo-pseudohypoparathyroidism and 33 newly identified muta-tions in the GNAS gene显示文摘 | Thiele S Werner R Grotzinger J | 2015 | Mol Genet Genomic Med2015，3，2： | 1 |
| 5 | Habitability, Taphonomy, and the Search for Organic Carbon on Mars显示文摘 | Grotzinger J P | 2014 | Science2014，343，6169： | 1 |
| 6 | Oxidation of the ediaearan ocean显示文摘 | Fike D Grotzinger J Pratt L | 2006 | Nature2006，444，7120： | 1 |
| 7 | In situ evidence for an ancient aqueous environment at Meridiani Planum,Mars显示文摘 | SQUYRES S W GROTZINGER J P ARVIDSON R E | 2004 | Science2004，5702，： | 1 |
| 8 | Peptide microarrays with site-specifically immobilized synthetic peptides for antibody diagnostics显示文摘 | Andresen H Grotzinger C Zarse K | 2006 | Sensors & Actuators B2006，113，： | 1 |
| 9 | Mars science laboratory mission and scienceinvestigation 显示文摘 | GROTZINGER J P CRISP J? VASAVADA A R | 2012 | Space Science Reviews2012，170，1： | 1 |
| 10 | 显示文摘 | Vu DN Gervois P Grotzinger T | 1997 | J Biol Chem1997，272，22： | 1 |
| 11 | Evidenee for anoxia at the Ediacaran-Cambrian boundary: The record of redox- sensitive trace elements and rare earth elements in Oman显示文摘 | SCHRODER S GROTZINGER J P | 2007 | Journal of the Geological Society2007，164，： | 1 |
| 12 | A study examininginter and intrarater reliability of three scales for measuring severity of psoriasis: psoriasis area and severity index, physician' s global assessment and lattice system physician' s global assessment 显示文摘 | BERTH-JONES J GROTZINGER K RAINVILLE C et al | 2006 | Br J Derma-tol2006，155，4： | 1 |
| 13 | Structure and mode of action of the antimicrobial peptide arenicin显示文摘 | Andra J Jakovkin I Grotzinger J | 2008 | Biochem J2008，410，1： | 1 |
| 14 | Sedimentary controls on the formation and preservation of microbial mats in siliciclastic depos- its: A case study from the Upper Neoproterozoic Nama Group, Namibia显示文摘 | Noffke N Knoll A Grotzinger J | 2002 | Palaios2002，17，： | 1 |
| 15 | Geochronologic constraints of the chronostratigraphic framework of theNeoproterozoic Huqf Supergroup,Sultanate of Oman显示文摘 | Bowring S.A Grotzinger J.P Condon D.J | | 0，，10： | 1 |
| 16 | Geochemical model for Proterozoic stromatolite decline显示文摘 | Grotzinger J P | 1990 | American Journal of Science1990，190，： | 1 |
| 17 | The science process for selecting the landing site for the 2011 Mars Science Laboratory显示文摘 | Grant J A Golombek M P Grotzinger J P | 2011 | Planetary and Space Science2011，59，11： | 1 |
| 18 | Calcified metazoans in thromblite-stromatolite reefs of the terminal Proterozoic Nama Group,Namibia显示文摘 | Grotzinger J P Watters W A Knoll A H | 2000 | Paleobiology2000，26，： | 1 |
| 19 | STRATA: Freeware for Solving Classic Stratigraphic Problems显示文摘 | Flemings P B Grotzinger J P | 1996 | GSA Today1996，6，12： | 1 |
| 20 | Improving the carboligase activity of benzoylformate decarboxylase from Pseudomonas putida by a combination of directed evolution and site-directed mutagenesis显示文摘 | Lingen B Grotzinger J Kolter D | 2002 | Protein Eng2002，15，： | 1 |
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