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| 1 | Liver cystic echinococcosis and human host immune and autoimmune follow-up:A review显示文摘Cystic echinococcosis(CE) is an infectious disease caused by the larvae of parasite Echinococcus granulosus(E.granulosus).To successfully establish an infection,parasite release some substances and molecules that can modulate host immune functions,stimulating a strong anti-inflammatory reaction to carry favor to host and to reserve self-survival in the host.The literature was reviewed using MEDLINE,and an open access search for immunology of hydatidosis was performed.Accumulating data from animal experiments and human studies provided us with exciting insights into the mechanisms involved that affect all parts of immunity.In this review we used the existing scientific data and discuss how these findings assisted with a better understanding of the immunology of E.granulosus infection in man.The aim of this study is to point the several facts that challenge immune and autoimmune responses to protect E.granulosus from elimination and to minimize host severe pathology.Understanding the immune mechanisms of E.granulosus infection in an intermediate human host will provide,we believe,a more useful treatment with immunomodulating molecules and possibly better protection from parasitic infections.Besides that,the diagnosis of CE has improved due to the application of a new molecular tool for parasite identification by using of new recombinant antigens and immunogenic peptides.More studies for the better understanding of the mechanisms of parasite immune evasion is necessary.It will enable a novel approach in protection,detection and improving of the host inflammatory responses.In contrast,according to the 'hygiene hypothesis',clinical applications that decrease the incidence of infection in developed countries and recently in developing countries are at the origin of the increasing incidence of both allergicand autoimmune diseases.Thus,an understanding of the immune mechanisms of E.granulosus infection is extremely important. | Nikica M Grubor Katica D Jovanova-Nesic Yehuda Shoenfeld | 2017 | World Journal of Hepatology2017，9，30： | 8 |
| 2 | Cystic lymphangioma of the pancreas显示文摘Lymphangioma of the pancreas is an extremely rare benign tumour of lymphatic origin,with fewer than 60 published cases. Histologically,it is polycystic,with the cysts separated by thin septa and lined with endothelial cells. Though congenital,it can affect all age groups,and occurs more frequently in females. Patients usually present with epigastric pain and an associated palpable mass. Complete excision is curative,even though,depending on the tumour location,surgery may be simple or involve extensive pancreatic resection and anastomoses. The authors present a 49-year-old woman in whom a polycystic septated mass,35 mm x 35 mm in size,was discovered by ultrasonography (US) in the body of the pancreas during investigations for epigastric pain and nausea. At surgery,a well circumscribed polycystic tumor was completely excised,with preservation of the pancreatic duct. The postoperative recovery was uneventful. Histology confirmed a microcystic lymphangioma of the pancreas. Immunohistochemistry showed cystic endothelial cells reactivity to factor Ⅷ -RA (++),CD31 (+++) and CD34 (-). Postoperatively,abdominal pain disappeared and the patient remained symptomfree for 12 mo until now. Although extremely rare,lymphangioma of the pancreas should be taken into consideration as a differential diagnosis of a pancreatic cystic lesion,especially in women. | Radoje B Colovic Nikica M Grubor Marjan T Micev Henry Dushan E Atkinson Vitomir I Rankovic Mihajlo M Jagodic | 2008 | World Journal of Gastroenterology2008，14，44： | 6 |
| 3 | Perigastric extraskeletal Ewing's sarcoma: A case report显示文摘Ewing's sarcoma (ES) is a neoplasm of undifferentiated small round cells, which occurs in the bones and deep soft tissues of children and adolescents. We present a rare case of a 44-year-old woman with gastric ES presenting with epigastric pain and weight loss. Ultrasound and computed tomography scans indicated a solid/cystic mass in the pancreatic tail. At laparotomy, the tumor was found attached to the posterior surface of the stomach, completely free from the pancreas, with no lymphadenopathy or local metastases. The polynodal, partly pseudocystic, dark-red soft tumor was excised. Histopathology revealed an anaplastic small-round-cell tumor with strong membranous CD99 immunoexpression. Additionally, there was patchy immunostaining for S-100 protein, vimentin, protein gene product (PGP) 9.5 and neuron-specifi c enolase, and weak focal CD117 cytoplasmic immunoreactivity. The patient had no adjuvant chemotherapy; her postoperative recovery was uneventful, and she remains symptom-free, and without any sign of recurrence at 20 mo. To the best of our knowledge, this is only the third ever case of gastric ES. | Radoje B Colovic Nikica M Grubor Marjan T Micev Slavko V Matic Henry Dushan Edward Atkinson Stojan M Latincic | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 4 | Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient显示文摘Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract,f irst described in the pancreas in 1977 and in the duodenum in 1979.They may be functional and cause somatostatinoma or inhibi-tory syndrome,but more frequently are non-functioning pancreatic endocrine tumors that produce somatostatin alone.They are usually single,malignant,large lesions,frequently associated with metastases,and generally with poor prognosis.We present the unique case of a 57-year-old woman with two synchronous non-function-ing somatostatinomas,one solid duodenal lesion and one cystic lesion within the head of the pancreas,that were successfully resected with a pylorus-preserving Whipple's procedure.No secondaries were found in the liver,or in any of the removed regional lymph nodes.The patient had an uneventful recovery,and remains well and symptom-free at 18 mo postoperatively.This is an extremely rare case of a patient with two synchro-nous somatostatinomas of the duodenum and the pancreas.The condition is discussed with reference to the literature. | Radoje B olovi Slavko V Mati Marjan T Micev Nikica M Grubor Henry Dushan Atkinson Stojan M Latini | 2009 | World Journal of Gastroenterology2009，15，46： | 1 |
| 5 | Treatment of Achilles tendon rupture using dif- ferent methods显示文摘 | Grubor P Grubor M | 2012 | Vojnosaah Pregl2012，69，8： | 1 |
| 6 | Effect of cold acclimation of the antioxidant defense system of two larval Lepidoptera (Noctuidae)显示文摘 | GRUBOR L G BLOCK W TELESMANIC M | 1997 | Archives of Insect Biochemistry and Physiology1997，36，1： | 1 |
| 7 | Developmental expression and distribution of sheep beta-defensin-2 显示文摘 | Heyerholz D K Gallup J M Grubor B | 2004 | DevComp Immunol2004，28，： | 1 |
| 8 | Inflammatory pseudotumors of the liver显示文摘 | COLOVIC R GRUBOR N MICEV M | 2002 | Srp Arh Colok Lek2002，130，78： | 1 |
| 9 | Effect of cold acclimation of the antioxidant defense system of two larval Lepidoptera (Noctuidae)显示文摘 | Grubor L G Block W Telesmanic M | 1997 | Archives of Insect Biochemistry and Physiology1997，36，1： | 1 |
| 10 | Biomass FBC combustion bed agglomeration problem 显示文摘 | Grubor B D Oka S N Llic M S | 1995 | Fluisized Bed Combustion ASME1995，1，1： | 1 |
| 11 | Inflammatory psedotumots of the liver显示文摘 | Coloric R Grubor N Micev M | 2002 | srp Arh Colok Lek2002，130，78： | 1 |
| 12 | Eeffect of cold acclimation of the antioxidant defense system of two larval Lepidoptera (Noctuidae)显示文摘 | Grubor Lajsic G Block W Telesmanic M | 1997 | Archives of Insect Biochemistry and Physiology1997，36，1： | 1 |
| 13 | Journal of the American Chemical Society显示文摘 | Grubor N M Liu Y Han X Armstrong D W Jankowiak R | 2006 | 128(19):64092006，128，19： | 1 |
| 14 | Biliobronchial fistula secondary to percutaneous dilatation of the benign biliary stricture显示文摘 | Colovic R Grubor N Kaitovic M | 2012 | Srp Arh Celok Lek2012，140，1112： | 1 |
| 15 | Inflammatory pseudotumors of the liver显示文摘 | Colovic R Grubor N Micev M | 2002 | Srp Arh Colok Lek2002，130，78： | 1 |
| 16 | Cystic iym- phangioma of the Pancreas 显示文摘 | Colovic R B Grubor N M Micev M T | 2008 | World J Gastroenterol2008，14，44： | 1 |
| 17 | Controversies in treatment of acetabular fracture显示文摘 | Grubor P Krupic F Biscevic M | 2015 | Med Arch2015，69，1： | 1 |
| 18 | Metastatic melanoma to the common bile duct causing obstructive jaundice:A case report显示文摘Metastatic melanoma to the common bile duct is very rare with only 18 cases reported so far. We report a 46 year old women who, 18 mo after excision of a skin melanoma, developped a painless progressive obstructive jaundice. At operation a melanoma within the distal third of the common bile duct was found. There were no other secondaries within the abdomen. The common bile duct, including the tumor, was resected and anastomosed with Roux-en-Y jejunal limb. The patient survived 31 mo without any sign of local recurrence and was submitted to three other operations for axillar and brain secondaries, from which she finally died. Radical resection of metastatic melanoma to the common bile duct may result in lifelong relief of obstructive jaundice. It is safe and relatively easy to perform. In other cases, a less aggressive approach, stenting or bypass procedures, should be adopted. | Radoje B Colovic Nikica M Grubor Miodrag D Jovanovic Marjan T Micev Natasa R Colovic | 2007 | World Journal of Gastroenterology2007，13，5： | 1 |
| 19 | Developmental expression and distribution of sheep beta- defensin-2 显示文摘 | MEYERHOLZ D K GALLUP J M GRUBOR B M | 2004 | Dev Complmmunol2004，28，2： | 1 |
| 20 | Transmandibular approach to polycentric recurrent pleomorphic adenoma of the parapharyngeal space显示文摘 | Grubor A Jovanovic M Said M | 2005 | Acta Chir Iugosl2005，52，3： | 1 |
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