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171篇 您的检索式：作者名="Grunwald J"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Rhodamin 123 as a probe of transmembrane potential in isolated rat-liver mitoehondria: spec- tral and metabolic properties 显示文摘	Emaus R K Grunwald Lemasters J J	1986	Biocbim Biophys Aeta1986，850，3：	1
3	Retinal haemodynamics in patients with early diabetes mellitus显示文摘	Grunwald JE Dupont J Riva CE		0，，：	1
4	Phosphorus in agricultral ditch soil and potential impications for water qulity显示文摘	DUNNE E J McKEE K A GRUNWALD S	2007	Journal of Soil and Water Conseration2007，62，4：	1
5	Formation, production and viability of oospores Phuytophthora infestans from potato and Solanum demissum in the Toluca Valley, Central Mexico 显示文摘	Flier W G Grunwald N J Fry W E	2001	Mycological Research2001，105，8：	1
6	Headwaters of the zebrafish--emergence of a new model vertebrate 显示文摘	GRUNWALD D J EISEN J S	2002	Nat Rev Genet2002，3，9：	1
7	Endovascular management of May-Thumer syndrome 显示文摘	Grunwald MR Goldberg M J Hofmarm LV	2004	Am J Roentgenol2004，183，：	1
8	Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria:spectral and metabolic properties显示文摘	EMAUS R K GRUNWALD R LEMASTERS J J	1986	Biochim Biophys Acta1986，850，3：	1
9	Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis显示文摘	Obermeier F Dunger N Strauch UG Grunwald N Herfarth H Scholmerich J	2003	Clin Exp Immunol2003，134，2：	1
10	Lupus vulgaris eornpli- caled by meta-static squamous cell carcinoma显示文摘	Yerushatmi J Grunwald MH Halevy DH	1998	International Journal of Dermatolugy1998，37，12：	1
11	Ultrasound and mammography guided wire marking of non-palpable breast lesions: analysis of 741 eases 显示文摘	Kohler J Krause B Grunwald S	2007	Ultraschall Med2007，28，3：	1
12	Huperzine A as a pre- treatment candidate drug against nerve agent toxicity 显示文摘	Grunwald J Raveh L Doctor P	1994	Life Sci1994，54，14：	1
13	Modeling of the spatial variability of biogeochemical soil properties in a freshwater ecosystem 显示文摘	Grunwald S Reddy K R Prenger J P	2007	Ecological Modelling2007，201，34：	1
14	Human butyrylchol- inesterase as a general prophylactic antidote for nerve agent toxicity显示文摘	Raveh L Grunwald J Marcus D	1993	Biochem Pharmaclo1993，45，：	1
15	Surgical treatment for neocortical temporal lobe epilepsy:clinical and surgical aspects and seizure outcome 显示文摘	Schramm J Kral T Grunwald T	2001	J Neurosurg2001，94，1：	1
16	Optic nerve blood flow in glaucoma:effect of systemic hypertension 显示文摘	Piltz J Hariprasad SM Dupont J Maguire MG	1999	Am J Ophthalmol1999，127，：	1
17	Outcomes of developmentally supportive nursing care for very low birth weight in- fants 显示文摘	Becker PT Grunwald PC Moorman J	1991	Nursing Research1991，40，3：	1
18	Proliferative heterogeneity of vascular smooth muscle cells and its alteration by injury 显示文摘	Haudenschid CC Grunwald J	1985	Exp Cell Res1985，157，：	1
19	Population ge- netics of shortnose sturgeon Acipenser brevirostrum based on mitochondrial DNA control region sequences显示文摘	Grunwald C Stabile J Waldman J R	2002	Mol Ecol2002，11，10：	1
20	Effects of hypertension on migration and proliferation of smooth muscle in culture 显示文摘	Haudenschid CC Grunwald J Chobanian AV	1985	Hypertension1985，7，：	1

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