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| 1 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 2 | Hybrid approach to surface roughness evaluation in multistage machining processes显示文摘 | Grzesik W Brol S | 2003 | Journal of Materials Processing Technology2003，134，： | 1 |
| 3 | Composite layer-based analytical models for tool-chip interface temperatures in machining medium carbon steels with multi-layer coated cutting tools显示文摘 | GRZESIK W | 2006 | Journal of Materials Processing Technology2006，176，： | 1 |
| 4 | Procalcitonin (PCT) concentration in cerebrospinal fluid and plasma of patients with purulent and lymphocytic meningoencephalitis -own observations 显示文摘 | Kapa L Oczzko- Grzesik B Bledowski D | 2005 | Przeql Epidemiol2005，59，3： | 1 |
| 5 | Bone matrix RGD glyeoproteins: immunolocalization and interaction with human primary osteoblastic bone cells in vitro显示文摘 | Grzesik WJ Robey PG | 1994 | J Bone Miner Res1994，9，4： | 1 |
| 6 | Macrophages regulate the angiogenic switch in a mouse model of breast cancer 显示文摘 | Lin 15Y Li JF Gnatovskiy L Deng Y Zhu L Grzesik DA | 2006 | Cancer Res2006，66，11： | 1 |
| 7 | An Investigation of the Thermal Effectsin Orthogonal Cutting Associated with Multilayer Coatings显示文摘 | Grzesik W | 2001 | Annals of the CIRP2001，501，： | 1 |
| 8 | Hydrostatic pressure activates ATP-sensitive K+channels in lung epithelium by ATP release through pannexin and connexin hemichannels显示文摘 | Richter K Kiefer KP Grzesik BA | 2014 | FASEB J2014，28，1： | 1 |
| 9 | Wavelet and fractal approach to surface roughness characterization after finishing turning of different workpiece materials显示文摘 | Grzesik W Brol S | 2009 | J Mater Process Techn2009，209，2： | 1 |
| 10 | Cementum and periodontal wound healing and regeneration显示文摘 | Grzesik WJ Narayanan AS | 2002 | Crit Rev Oral Biol Med2002，13，6： | 1 |
| 11 | Investigations on friction and wear mechanisms of the PVD- TiA1N coated carbide in dry sliding against steels and east iron 显示文摘 | Grzesik W Zalisz Z Krol S | 2006 | Wear2006，261，1112： | 1 |
| 12 | Wear development on wiper Al2O3 - TiC mixed ceramie tools in hard maehining of high strength steel 显示文摘 | W Grzesik | 2009 | Wear2009，266，910： | 1 |
| 13 | Hydrostatic pressure activates ATP-sensitive K+ channels in lung epithelium by ATP release through pannexin and connexin hemichannels显示文摘 | Richter K Kiefer KP Grzesik BA | 2014 | FASEB J2014，28，1： | 1 |
| 14 | Effect of Asahi SL on China aster ‘Aleksandra’ seed yield, germination and some metabolic events显示文摘 | Krzysztof Górnik Mieczys?aw Grzesik | 2002 | Acta Physiologiae Plantarum2002，，4： | 1 |
| 15 | An energy approach to chip-breaking when machining with grooved tool inserts显示文摘 | W. Grzesik E. Kwiatkowska | 1997 | International Journal of Machine Tools and Manufacture1997，，5： | 1 |
| 16 | Kinetics of oxida- tive dehydrogenation of propane over V2Os/TiO2 catalyst 显示文摘 | Grabowski R Stoczyfiski J Grzesik N M | 2003 | Appl Catal A : General2003，242，2： | 1 |
| 17 | Normal human cementum-derived cells:isolation,clonal expansion, and in Vitro and in vivo显示文摘 | Grzesik WJ Kuzentsov SA Uzawa K | 1998 | Journal of Bone and Miner Research1998，13，10： | 1 |
| 18 | Investigations on friction and wear mechanisms of the PVD-TiAlN coated carbide in dry sliding against steels and cast iron显示文摘 | Grzesik W Zalisz Z Krol S | 2006 | Wear2006，261，： | 1 |
| 19 | The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system 显示文摘 | Matsukawa N I Grzesik W J Takahashi N | 1999 | Proc Natl Acad Sci U S A1999，96，13： | 1 |
| 20 | Determination of Temperature Distribution in the Cutting Zone Using Hybrid Analytical-FEM Technique显示文摘 | W Grzesik | 2006 | Int-ernational Journal of Machine Tools&Manufacture2006，，65： | 1 |
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