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| 1 | Conductive polymer-modified boron-doped diamond for DNA hybridization analysis 显示文摘 | Gu Huiru Su Xiaodi Kian Ping Loh | 2004 | Chem Phys Lett2004，388，4： | 1 |
| 2 | Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway显示文摘Background Liver fibrosis and hepatocellular carcinogenesis secondary to liver fibrosis are serious liver diseases with no effective treatments.Mori fructus aqueous extracts(MFAEs)have served as successful treatments for many types of liver injury including fibrosis although the molecular mechanisms are unknown at present.Purpose To investigate the effect of MFAEs in alleviating acute and chronic liver injury and tried to decipher the underlying mechanism.Methods and results Mice were divided into 5 groups(n ps:contro=8)for acute(groups:control,0.3%CCl_(4),bifendate(BD),100 and 200 mg/kg MFAEs,7 d)and chronic(groul,10%CCl_(4),BD,100 and 200 mg/kg MFAEs,4 weeks)liver injury study.Each mouse was injected intraperitoneally with 10μL/g corn oil containing CCl_(4)expect the control group.HepG2 cells were used in vitro study.Eighteen communal components were identified by UPLC-LTQOrbitrap-MS.We utilized a mouse model for acute and chronic liver injury using CCl_(4)and MFAEs administration effectively blocked fibrosis and significantly inhibited inflammation in the liver.MFAEs activated the nuclear factor erythroid derived 2 like 2/heme oxygenase 1(Nrf2/HO-1)pathway and promoted the synthesis of the antioxidants glutathione(GSH),superoxidedismutase(SOD)and glutathione peroxidase(GSH-Px)that resulted in reduced levels of CCl_(4)-induced oxidative stress molecules including reactive oxygen species.These extracts administered to mice also inhibited ferroptosis in the liver by regulating the expression of Acyl-CoA synthetase long chain family member 4(ACSL4),solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4),thus reducing the occurrence of liver fibrosis.Both in vivo and in vitro tests indicated that the mechanism of MFAEs protection against liver fibrosis was linked to activation of Nrf2 signaling.These effects were blocked in vitro by the addition of a specific Nrf2 inhibitor.Conclusion MFAEs inhibited oxidative stress,ferroptosis and inflammation of the liver by activating Nrf2 signal pathway and provided a significant protective effect against CCl_(4)-induced liver fibrosis. | Yuanyuan Wei Chen Gao Huiru Wang Yannan Zhang Jinhua Gu Xiuying Zhang Xuhao Gong Zhihui Hao | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 1 |
| 3 | The bone alterations in hind limb amputation rats in vivo显示文摘Osteoporosis,which is characterized by bone loss,increases the risk of fractures and s and seriously affected the amputee’s health.Muscle mass is an important factor affecting bone mineral density(BMD).Muscular atrophy and decreased muscle mass can cause BMD to fall.The bone quantity and quality are used to assess by Microcomputer tomography(micro-CT)with non-destructive.To investigate the performance of micro-CT in evaluating amputation-induced osteopenia in rats,the micro-CT was used to evaluate the change of the microstructure in trabecular bone and cortical bone of amputation.Muscle morphology was analyzed by micro-CT and transmission electron microscopy.Female Sprague–Dawley rats(8 week old)were divided into two groups:control(CON)groups and left hind limb amputation(LHLA).At 35 days,microstructure and volumetric bone mineral density(vBMD)of the tibia and femur were detected through micro-CT.The results showed:(1)the trabecular and cortical vBMD of the proximal tibia and distal femur in the LHLA group were significantly lower than those in the CON group.(2)Compared with the CON group,the trabecular number,bone volume fraction and trabecular thickness of proximal tibia and distal femur in LHLA group decreased significantly,whereas the trabecular separation,structure model index and bone surface/bone volume increased significantly in LHLA group.(3)The whole cross-sectional area(CSA)of whole calf muscles of left limb in LHLA group decreased significantly compared with CON group.In general,hind limb amputation could cause bone loss,changes in the microstructure of trabecular bone and muscle atrophy.Micro-CT is sensitive in evaluating bone microstructure destruction caused by amputation,and can be used for early diagnosis or monitor the development of bone loss in amputation in vivo. | Huiqin Luan Huiru gu Zhongjun Mo Weiyan Ren Huan Guo Zhaowei Chu Yubo Fan | 2020 | Medicine in Novel Technology and Devices2020，，4： | 0 |
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