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| 1 | Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy显示文摘Nanoparticulate drug delivery systems(Nano-DDSs) have emerged as possible solution to the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are restricted by several drawbacks, such as low drug loading, premature drug leakage and carrier-related toxicity.Recently, pure drug nano-assemblies(PDNAs), fabricated by the self-assembly or co-assembly of pure drug molecules, have attracted considerable attention. Their facile and reproducible preparation technique helps to remove the bottleneck of nanomedicines including quality control, scale-up production and clinical translation. Acting as both carriers and cargos, the carrier-free PDNAs have an ultra-high or even100% drug loading. In addition, combination therapies based on PDNAs could possibly address the most intractable problems in cancer treatment, such as tumor metastasis and drug resistance. In the present review, the latest development of PDNAs for cancer treatment is overviewed. First, PDNAs are classified according to the composition of drug molecules, and the assembly mechanisms are discussed. Furthermore, the co-delivery of PDNAs for combination therapies is summarized, with special focus on the improvement of therapeutic outcomes. Finally, future prospects and challenges of PDNAs for efficient cancer therapy are spotlighted. | Shuwen Fu Guanting Li Wenli Zang Xinyu Zhou Kexin Shi Yinglei Zhai | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 4 |
| 2 | Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis显示文摘天门冬素(Asn/N ) 连接了 glycans 为蛋白质合拢, trafficking,和 endoplasmic 是重要的在优核质的联系蜂窝胃的降级。glycoproteins 的成熟包含在 Golgi 由另外的糖分子的 mannosidases 和三分支的 N-glycans 的增加整修 mannosyl 残余。然而,调停 Golgi 的甘露糖整修的生物重要性充分没被理解。这里,我们显示出二机能上地冗余的 mannosidases, MNS1 和 MNS2 的那废除,为在 A 和工厂 N-glycans 的 C 分支上整修的 -1,2-mannose 负责在 Arabidopsis 在盐压力条件下面导致严重的根生长抑制。相反,有在 oligosaccharide 先锋的生合成的缺点的异种当甘露糖整修不在时显示了提高的盐忍耐。然而,在 EBS3 的变化,为分叉的 N-glycan 先锋的形成被要求,压制了 mns1 mns2 的盐敏感的显型两倍异种。有趣地,我们观察了那 ? 纤维素生合成在高咸度下面在 mns1 mns2 根被损害。一致地, ? 许多膜抛锚了 endo -- 在纤维素生合成起一个关键作用的 1,4-endoglucanase (RSW2/KOR ) 和它的变异的变体 rsw2-1 ? 被调制由 ? 在盐应力下面整修的 -1,2-mannose。RSW2 的 Overexpression 能部分救 mns1 mns2 的盐敏感的显型。一起拿,这些结果建议 N-glycans 整修的那 MNS1/2-mediated 甘露糖在 modulating glycoprotein 丰富是关键的在植物承受盐应力。 | Chuanfa Liu Guanting Niu Huchen Zhang Yafei Sun Shubin Sun Fugen Yu Shan Lu Yonghua Yang Jianming Li Zhi Hong | 2018 | Molecular Plant2018，11，5： | 3 |
| 3 | A H9N2 Human Case and Surveillance of Avian Influenza Viruses in Live Poultry Markets-Huizhou City,Guangdong Province,China,2021显示文摘Summary What is already known about this topic?An increasing number of human infected avian influenza A(H9N2)cases have been reported.In 2021,11 human infections with influenza A virus subtype H9N2(A/H9N2)have been reported in China.What is added by this report?A new case of H9N2 that occurred in April 2021 in Huizhou City,Guangdong Province,China,was reported in this study.Epidemiological and laboratory information of the case and routine influenza surveillance data of avian influenza A were presented in this report.What are the implications for public health practice?The emergence of a human infected with Avian Influenza Virus H9N2 demonstrates that there is an urgent need to strengthen the surveillance of influenza-like illness and live poultry market. | Guanting Zhang Liqin Xu Jian Zhang Qiaoyun Fang Jianjun Zeng Yan Liu Changwen Ke | 2022 | China CDC weekly2022，4，1： | 2 |
| 4 | Universal triple I fuzzy reasoning algorithm of function model based on quotient space显示文摘Aiming at the deficiencies of analysis capacity from different levels and fuzzy treating method in product function modeling of conceptual design,the theory of quotient space and universal triple I fuzzy reasoning method are introduced,and then the function modeling algorithm based on the universal triple I fuzzy reasoning method is proposed.Firstly,the product function granular model based on the quotient space theory is built,with its function granular representation and computing rules defined at the same time.Secondly,in order to quickly achieve function granular model from function requirement,the function modeling method based on universal triple I fuzzy reasoning is put forward.Within the fuzzy reasoning of universal triple I method,the small-distance-activating method is proposed as the kernel of fuzzy reasoning;how to change function requirements to fuzzy ones,fuzzy computing methods,and strategy of fuzzy reasoning are respectively investigated as well;the function modeling algorithm based on the universal triple I fuzzy reasoning method is achieved.Lastly,the validity of the function granular model and function modeling algorithm is validated.Through our method,the reasonable function granular model can be quickly achieved from function requirements,and the fuzzy character of conceptual design can be well handled,which greatly improves conceptual design. | Lu Qiang Shen Guanting and Liu Xiaoping | 2012 | Computer Aided Drafting,Design and Manufacturing2012，22，1： | 1 |
| 5 | A Formal Model of Collaborative Discussion for Problem-Solving显示文摘 | LIU Xiaoping TANG Yiming SHEN Guanting CHEN Xin | 2012 | Chinese Journal of Electronics2012，21，3： | 1 |
| 6 | CTAB-Assisted Hydrothermal Synthesis of Silver Vanadates and Their Photocatalytic Characterization 显示文摘 | Huang Chaoming Cheng Kongwei Pan Guanting | 2010 | Chem Eng Sci2010，65，1： | 1 |
| 7 | Crystalline Phases and Photocatalytic Activities of Hydrothermal Synthesis Ag3 VO4 and Ag4 V2 07 Under Visible Light Irradiation 显示文摘 | Huang Chaoming Pan Guanting Li Yuchu | 2009 | Appl Catal A2009，358，2： | 1 |
| 8 | Atom-surface diffraction:a trajectory description显示文摘 | Guantes R Sanz A S Margalef-Roig J Miret-Artes S | 2004 | Surf Sci Rep2004，53，： | 1 |
| 9 | Periodic solutions of 2+1 dimensional nonlinear evolution equations显示文摘 | LIU Guanting FAN Tiangou | 2004 | Journal of Inner Mongolia Normal University2004，33，4： | 1 |
| 10 | Management of Post-traumatic Aniridia with Retinal Detachment显示文摘Purpose: To reconstruct the anatomic and functional impairment in patients with post-traumatic aniridia, aphakia, and retinal detachment.
Methods: Four patients with unilateral aniridia and aphakia as well as retinal detachment as results of severe eye injuries underwent scleral buckling, vitrectomy, membrane peeling, endolaser photocoagulation, silicone oil or gas temponade, combined with iris diaphragm-IOL implantation.
Results: All four patients achieved successfully anatomic and functional reconstruction after surgery. During five to 22 months postoperative follow-up, all retinas remained attached. The final visual acuity increased from finger counting to 0.1 ~ 0.3.
Conclusions: The combination of vitreoretinal surgery and iris diaphrgm-IOL implantation is an effective method for post-traumatic aniridia, aphakia and traumatic retinal detachment. It could ameliorate photophobia and improve the biocular vision.Furthermore, artificial iris diaphragm implantation could prevent silicone oil-endothelia contact and salvage silicone keratopathy. Eye Science 2001; 17:35 ~ 38. | Shibo Tang, Guanting Qiu, Pei Wang, Xiaoling LiangZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China | 2001 | Eye Science2001，17，1： | 1 |
| 11 | Governing equations and general solutions of plane elasticity of one-dimensional quasicrystals显示文摘 | Liu Guanting Fan Tianyou Guo Ruiping | 2004 | Int J Solids and Structures2004，41，14： | 1 |
| 12 | A ventilator weaning prediction system with artificial intelligence显示文摘 | Chen AH Chen Guanting | 2007 | Lecture Notes in Computer Science2007，4901，： | 1 |
| 13 | 显示文摘 | Li Chishing Su Shuihsiang Chen Guanting | 2008 | Chinese Journal of Electron Devices2008，31，1： | 1 |
| 14 | SEMI-ELLIPTIC SURFACE CRACK IN AN ELASTIC SOLID WITH FINITE SIZE UNDER IMPACT LOADING显示文摘在这篇论文,在在装载的影响下面的有限尺寸的有弹性的固体的一个半椭圆形的表面裂缝问题被调查。分析借助于破裂动力学和有限元素方法被执行,并且一个三维的有限元素程序被开发计算动态压力紧张因素。结果表明 solid'sboundary 表面,裂缝表面,材料惯性和压力的效果挥动相互作用玩在动态骨折的重要角色。 | Guo Ruiping Liu Guanting Fan Tianyou | 2006 | Acta Mechanica Solida Sinica2006，19，2： | 1 |
| 15 | Governing equations and general solutions of plane elasticity of one-dimensional quasicrystals 显示文摘 | Liu Guanting Fan Tianyou Guo Ruiping | 2004 | Int J Solids and St ructures2004，41，14： | 1 |
| 16 | Cryatal- Iine phases and photocatalytic activities of hydrothermal syn- thesis Ag3 VO4 and Ag4V2O7 under visible light irradiation 显示文摘 | Huang Ghaoming Pan Guanting Yuchu M Li | 2009 | Applied Catalysis A General2009，358，： | 1 |
| 17 | Young age as an in dependent adverse prognostic factor in premenopausal patients with breast cancer显示文摘 | DubskyPC Guant Michael FX Taueher S | 2002 | Ciin Breast Cancer2002，3，1： | 1 |
| 18 | A costeffective planning graph approach for large-scale web service composition显示文摘 | Lin S Y Lin Guanting Chao Kuoming | 2012 | Mathematical Problems in Engineering2012，，： | 1 |
| 19 | Abnormal DNA repair in selenium-treated human cells显示文摘 | ABUL-HASSAN K S LEHNERT B E GUANT L | 2004 | Mutat Res2004，565，1： | 1 |
| 20 | Lame equation and asymptotic higher - order periodic solutions to nonlinear evolution equations 显示文摘 | Liu Guanting | 2009 | Applied Mathematics and Computation2009，212，： | 1 |
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