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| 1 | A simple and very efficient method for generating cDNA libraries 显示文摘 | Gubler U Hoffman BJ | 1983 | Gene1983，25，23： | 2 |
| 2 | Over-the-scope-clip closure of long lasting gastrocutaneous fistula after percutaneous endoscopic gastrostomy tube removal in immunocompromised patients:A single center case series显示文摘Over-the-scope-clips(OTSC~?) have been shown to be an effective and safe endoscopic treatment option for the closure of gastrointestinal perforations, leakages and fistulae. Indications for endoscopic OTSC~? treatment have grown in number and also include gastro cutaneous fistula(GCF) after percutaneous endoscopic gastrostomy(PEG) tube removal. Non-healing GCF is a rare complication after removal of PEG tubes and may especially develop in immunosuppressed patients with multiple comorbidities. There is growing evidence in the literature that OTSC~? closure of GCF after PEG tube removal is emerging as an effective, simple and safe endoscopic treatment option. However current evidence is limited to the geriatric population and short standing GCF, while information on closure of long standing GCF after PEG tube removal in a younger population with significant comorbidities is lacking. In this retrospective single-center case-series we report on five patients undergoing OTSC~? closure of chronic GCF after PEG tube removal. Four out of five patients were afflicted with long lasting, symptomatic fistulae. All five patients suffered from chronic disease associated with a catabolic metabolism(cystic fibrosis, chemotherapy for neoplasia, liver cirrhosis). The mean patient age was 43 years. The mean dwell time of PEG tubes in all five patients was 808 d. PEG tube dwell time was shortest in patient 5(21 d). The mean duration from PEG tube removal to fistula closure in patients 1-4 was 360 d(range 144-850 d). The intervention was welltolerated by all patients and no adverse events occured. Successful immediate and long-term fistula closure was accomplished in all five patients. This single center case series is the first to show successful endoscopic OTSC~? closure of long lasting GCF in five consecutive middleaged patients with significant comorbidities. Endoscopic closure of chronic persistent GCF after PEG tube removal using an OTSC~? was achieved in all patients with no immediate or long-term complications. OTSC~? is a promising endoscopic treatment option for this condition with a potentially high immediate and long term success rate in patients with multiple comorbidities. | Henriette Heinrich Christoph Gubler Piero V Valli | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 2 |
| 3 | “Sparing the surgeon”: clinical experience with over-the-scope clips for gastrointestinal perforation显示文摘 | L. Seebach P. Bauerfeind C. Gubler | 2010 | Endoscopy2010，，12： | 2 |
| 4 | Endoscopic full-thickness resection in the colorectum with a novel over-the-scope device: first experience显示文摘 | Arthur Schmidt Peter Bauerfeind Christoph Gubler Michael Damm Markus Bauder Karel Caca | 2015 | Endoscopy2015，，： | 2 |
| 5 | Zika virus: following the path of dengue and chikungunya?显示文摘 | Didier Musso Van Mai Cao-Lormeau Duane J Gubler | 2015 | The Lancet . 2015 (9990)2015，，： | 2 |
| 6 | WT1 and glomerular diseases显示文摘 | Niaudet P Gubler MC | 2006 | Pediatr Nephrol2006，21，11： | 1 |
| 7 | Molecular evolution and phylogeny of dengue 4 viruses 显示文摘 | Lanciotti RS Gubler DJ Trent DW | 1997 | J Gen Virol1997，78，： | 1 |
| 8 | The Arabidopsis GAMYB-like genes, MYB33 and MYB65, are MicroRNA-regulated genes that redundantly facilitate anther development 显示文摘 | Millar A A Gubler F | 2005 | Plant Cell2005，17，3： | 1 |
| 9 | Rapid detection andtyping of Dengue viruses from clinical samples by using reversetranscriptase-polymerase chain reaction显示文摘 | Lanciotti RS Calisher CH Gubler DJ | 1992 | J Clin Microbiol1992，30，3： | 1 |
| 10 | Variation in susceptibility to oral infection with dengue viruses Aedes aegypti显示文摘 | Gubler DJ Nalim S Tan R | 1979 | Am J Trop Med Hyg1979，28，： | 1 |
| 11 | Two human TNF receptors have similar extracellular, but distinct lnuacellar domain sequences显示文摘 | Dembic Z Locrscher H Gubler U | 1990 | Cytokine1990，2，： | 1 |
| 12 | Dengue and dengue haemorrhagic fever显示文摘 | Rigau-Perez JZ Clark GG Gubler DJ | 1998 | Lancet1998，352，： | 1 |
| 13 | Co- expression of two distinct genes is required to generate secre- ted bioactive cytotoxic lymphocyte maturation factor显示文摘 | GUBLER U CHUA A-O SCHOENHAUT D S | 1991 | Proc Nati Acad Sci USA1991，88，10： | 1 |
| 14 | Gibberellin-responsive elements in the promoter of a barley high-pI α-amylase gene显示文摘 | Gubler F Jacobsen JV | 1992 | Plant Cell1992，4，： | 1 |
| 15 | Emerging flaviviruses:the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses显示文摘 | Mackenzie JS Gubler DJ Petersen LR | | 0，，： | 1 |
| 16 | Gibberellin signaling: Biosynthesis, catabolism, and response pathways显示文摘 | Olszewski N Sun TP Gubler F 2002 | 2002 | Plant Cell2002，14，： | 1 |
| 17 | Gibberenllin signaling: Biosynthesis, catabolism, and response pathways显示文摘 | Olszewski N Sun T Gubler F | 2002 | Plant Cell2002，，： | 1 |
| 18 | Human IL - 12 p40 homodimer binds to the IL - 12 receptor but does not mediate biologic activity显示文摘 | Ling P Gately MK Gubler U | 1995 | J Immunol1995，154，1： | 1 |
| 19 | Dengue and dengue haemorrhagic显示文摘 | Gubler DJ | 1998 | Clin Microbiol Rev1998，，11： | 1 |
| 20 | Reducing accidental in- juries during surgery显示文摘 | Edlich RF Long WB 3rd Gubler K | 2010 | J Environ Pathol Toxico] Onco12010，29，4： | 1 |
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