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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Photochemical processes and the environmental impact of petroleum spills 显示文摘 | Nicodem D E Fernandes M C Z Guedes C L B | 1997 | Biogeochemistry1997，39，： | 1 |
| 3 | Systematic study of a brazilian intermediate crude oil 显示文摘 | Nicodem D E Guedes C L B Correa R J Photochemistry of petroleum I | 1997 | MarChem1997，63，： | 1 |
| 4 | Contact indentation of marine composites显示文摘 | SUTHERLAND L S GUEDES SOARES C | 2005 | Composite Structures2005，70，3： | 1 |
| 5 | Time-dependent reliability of the primary ship structure 显示文摘 | Guedes Soares C Ivanov L D | 1989 | Reliability Engineering and System Safety1989，26，： | 1 |
| 6 | Time do main modeling of the transient asymmetric flooding of Ro-Ro ship显示文摘 | T A Santos L E Winkle C Guedes Soares | 2002 | Ocean Engineering2002，，： | 1 |
| 7 | H2 and Hinfin: designs for diving and course control of an autonomous underwater vehicle in presence of waves显示文摘 | Moreira L Guedes S C | 2008 | IEEE Journal of Oceanic Engineering2008，33，2： | 1 |
| 8 | Validation of an immunoperoxidase monolayer assay as a serologic test for porcine proliferative enteropathy 显示文摘 | Guedes R M Gebhart C J Deen J Winkelman N L | 2002 | J Vet Diagn Invest2002，14，6： | 1 |
| 9 | The coverage problem in video-basedwireless sensor networks:A survey显示文摘 | Costa D G Guedes L A | 2010 | Sensors2010，10，9： | 1 |
| 10 | Worldwide frequen- cy of G2019S LRRK2 mutation in Parkinson's disease: a system- atic review显示文摘 | Correia Guedes L Ferreira J Rosa M | 2010 | Parkinsonism Relat Disord2010，16，4： | 1 |
| 11 | miR-155 modulates microgliamediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production 显示文摘 | Cardoso AL Guedes JR Pereira de Almeida L | 2012 | Immunology2012，135，1： | 1 |
| 12 | The effects of tests parameters on the impact response of glass reinforced plastic using an experimental design approach显示文摘 | SUTHERLAND L S GUEDES S C | 2003 | Composites Science and Technology2003，63，1： | 1 |
| 13 | Assessment of a phosporus fractionation method for soils: problems for further investigation 显示文摘 | Potter R L Jordan C F Guedes R M | 1991 | Agriculture Ecosystems and Environment1991，34，： | 1 |
| 14 | Long-term safety of intravascular ultrasound in nontransplant,nonintervened,atheroselerotic coronary arteries显示文摘 | Keller PL Allier L | 2005 | J Am Coil Cardiol2005，45，4： | 1 |
| 15 | Techniques for Providing QoS in Mobile Cellular Networks Based on CAC and Resource Reservation at the Origin and Destination显示文摘 | Solange S Guedes L G R Roberto G P | 2006 | IEEE Transactions on Latin America2006，4，5： | 1 |
| 16 | Dynamic Model of Ma- noeuvrability Using Recursive Neural Networks 显示文摘 | MOREIRA L GUEDES S C | 2003 | Ocean Engineering2003，30，13： | 1 |
| 17 | Reliability and availability evaluation of wireless sensor networks for industrial applications 显示文摘 | Silva I Guedes L A Portugal P | 2012 | Sensors2012，12，1： | 1 |
| 18 | An experimental study of the wake of gas slugs rising in liquids显示文摘 | CAMPOS J B L M GUEDES DE CARVALHO J R F | 1988 | Journal of Fluid Mechanics1988，196，： | 1 |
| 19 | Optical coherence tomography and histologic measurements of nerve fiber layer thickness in normal and glaucomatous monkey eyes 显示文摘 | Schuman JS Pedut-Kloizman T Pakter H Wang N Guedes V Huang L | 2007 | Invest Ophthalmol Vis Sci2007，48，8： | 1 |
| 20 | ELISA for early diagnosis of histoplasmosis显示文摘 | Guimaraes A J Pizzini C V Guedes H L | 2004 | J Med Microbiol2004，53，6： | 1 |
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