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| 1 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 2 | Starch Digestibility and Physicochemical and Cooking Properties of Irradiated Rice Grains显示文摘This study evaluated the starch digestibility, physicochemical properties and cooking characteristics of polished rice(varieties IRGA417 and IAC202) subjected to the doses of 0(as the control), 1, 2 and 5 k Gy of gamma radiation. The highest dose decreased the apparent amylose content, peak viscosity, water absorption and volume expansion. Irradiation increased the solid loss by 119% and 187% for IAC202 and IRGA417, respectively, when comparing the higher dose with the control. For IAC202, irradiation decreased the rapidly digestible starch and increased the slowly digestible starch(SDS) and resistant starch(RS). IRGA417 showed an elevation of SDS and a reduction in RS. And 1 k Gy dose of gamma radiation generated the highest level of RS for both the two varieties and presented the smallest changes in other physicochemical and cooking properties. | Luís Fernando POLESI Manoel Divino da MATTA JUNIOR Silene Bruder Silveira SARMENTO Solange Guidolin CANNIATTI-BRAZACA | 2017 | Rice science2017，24，1： | 3 |
| 3 | Acid hydrolysis and fermentation of brewer’s spent grain to produce xylitol显示文摘 | Solange IMussatto Inês CRoberto | 2005 | J Sci Food Agric2005，，14： | 1 |
| 4 | Dilute-acid hydrolysis for optimization of xylose recovery from rice straw in a semi-pilot reactor显示文摘 | Inês C Roberto Solange I Mussatto Rita C.L.B Rodrigues | 2002 | Industrial Crops & Products2002，，3： | 1 |
| 5 | The Akt/PKB phosphorylation in cardiac muscle is modulated by an exercise training program显示文摘 | Solange M Franzói-De-Moraes S B Peres | 2000 | Diabetes Research and Clinical Practice2000，50，： | 1 |
| 6 | Techniques for Providing QoS in Mobile Cellular Networks Based on CAC and Resource Reservation at the Origin and Destination显示文摘 | Solange S Guedes L G R Roberto G P | 2006 | IEEE Transactions on Latin America2006，4，5： | 1 |
| 7 | Alternatives for detoxification of diluted-acid lignocellulosic hydrolyzates for use in fermentative processes: a review显示文摘 | Solange Inês Mussatto Inês Concei??o Roberto | 2003 | Bioresource Technology2003，，1： | 1 |
| 8 | Sawdust:A green and economical sorbent for thallium removal显示文摘 | MEMON S Q MEMON N SOLANG A R | 2008 | Chemical Engineering Journal2008，140，： | 1 |
| 9 | Zener tunneling in two-dimensional photonic lattices显示文摘 | Valery S Shchesnovich Solange B Cavalcanti Jandir M Hickmann | 2006 | Phys Rev E2006，，05： | 1 |
| 10 | Smart coating based on polyaniline acrylic blend for corrosion protection of different metals显示文摘 | Solange D S | 2007 | Surface and Coatings Technology2007，2，： | 1 |
| 11 | Interference of some aqueous two-phase system phase-forming components in protein determination by the Bradford method显示文摘 | Sara C. Silvério Sérgio Moreira Adriane M.F. Milagres Eugénia A. Macedo José A. Teixeira Solange I. Mussatto | 2011 | Analytical Biochemistry2011，，2： | 1 |
| 12 | Propolis: recent ad- vances in chemistry and plant origin显示文摘 | Bankova V S Solang E Marcucci M C | 2000 | Apidologie2000，31，： | 1 |
| 13 | Influence of the toxic compounds present in brewer’s spent grain hemicellulosic hydrolysate on xylose-to-xylitol bioconversion by Candida guilliermondii显示文摘 | Solange I. Mussatto Giuliano Dragone Inês C. Roberto | 2005 | Process Biochemistry2005，，12： | 1 |
| 14 | Study of xylitol production by Candida guilliermondii on a bench bioreactor 显示文摘 | Carla J S M Silva Solange I Mussatto Ines C Roberto | 2006 | Journal of Food Engineering2006，75，1： | 1 |
| 15 | Propolis:recent advances in chemistry and plant origin显示文摘 | Vassya S Bankova Solange L | 2000 | Apidologie2000，31，： | 1 |
| 16 | Sawdust:A green andeconomical sorbent for thallium removal显示文摘 | MEMON S Q MEMON N SOLANG A R | 2008 | Chemical Engineering Jour-nal2008，140，： | 1 |
| 17 | Cell immobilization and xylitol production using sugarcane bagasse as raw material显示文摘 | Silva Silvio S Mussatto Solange I Santos Julio C | 2007 | Applied Biochemistry and Biotechnology2007，141，23： | 1 |
| 18 | Propolis: recent advances in chemistry and plant origin显示文摘 | BANKOVA V S SOLANGE MARCUCCI M C | 2000 | Apidologie2000，31，： | 1 |
| 19 | Evaluation of porous glass and zeolite as cells carriers for xylitol production from sugarcane bagasse hydrolysate显示文摘 | Julio C S Solange I M Giuliano D | 2005 | Biochemical Engineering Journal2005，23，： | 1 |
| 20 | Evaluation of porous glass and zeolite as ceils carriers for xylitol production from sugarcane bagasse hydrolysate显示文摘 | Julio C S Solange I M Giuliano D | 2005 | Biochemical Engineering Journal2005，23，： | 1 |
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