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| 1 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 2 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 3 | Chromenes of polyketide oridin from Peperomia villipetiola 显示文摘 | KARINA J M S GUILLERMO E D P LI5IS R L | 2005 | Phytochemistry2005，66，5： | 1 |
| 4 | Chromenes of polyketide oridin from Peperomia villipetiola 显示文摘 | Karina J M S Guillermo E D P Luis R L | 2005 | Phytochemistry2005，66，： | 1 |
| 5 | Nitrogen availability influences the biochemical composition and photosynthesis of tank-cultivated Ulva rigida (Chlorophyta)显示文摘 | Juan Luis Gómez Pinchetti Elena del Campo Fernández Paula Moreno Díez Guillermo García Reina | 1998 | Journal of Applied Phycology1998，，4： | 1 |
| 6 | 1H and DOSY NMR spectroscopy analysis of Ligusticum porteri rhizome extracts 显示文摘 | Alejandra L Maria Isabel C Guillermo D | 2011 | Magn Reson Chem2011，49，8： | 1 |
| 7 | Cell-wall polysaccharide modifications during postharvest ripening of papaya fruit (Carica papaya)显示文摘 | Guillermo D M Franco M L | 2004 | Postharvest Biol Tec2004，33，1： | 1 |
| 8 | Purification and characterization of urease from Helicobacter pylori显示文摘 | Bruce E D Campbell G P Guillermo I | 1990 | The J of Biological Chemistry1990，265，： | 1 |
| 9 | Marrow stromal cells, mitosis, and neuronal differentiation: stem cell and precursor functions显示文摘 | Guillermo M E Woodbury D Black I B | 2003 | Stem cells2003，21，3： | 1 |
| 10 | A plate technique for screening of inulin degrading microorganisms显示文摘 | Guillermo R Castro Mario D Baigorí Faustino Si?eriz | 1995 | Journal of Microbiological Methods1995，，1： | 1 |
| 11 | Comparison of four methods of grassland productivity assessment based on Festuca pallescens phytomass data 显示文摘 | Guillermo E D Rertiller M B | 1991 | Journal of Range Management1991，44，3： | 1 |
| 12 | Decreased Activity of the L - Arginine - Nitric Oxide Metabolic Pathway in Patients With Congestive Heart Failure显示文摘 | Stuart D K Tehreen K Guillermo A Z | 1999 | Circulation1999，99，： | 1 |
| 13 | XrML-eXtensible rights Markup Language显示文摘 | Xin W Thomas D Guillermo L | 2002 | ACM Workshop on XML Security2002，22，： | 1 |
| 14 | Highly hydrophobic wood surfaces prepared by treatment with atmospheric pressure dielectric barrier discharges显示文摘 | Toriz Guillermo Guti 8 rrez Milagros G Gonz d lez- Alvarez V i ctor | 2008 | Journal of Adhesion Science and Technology2008，22，16： | 1 |
| 15 | Retraction and triangulation with neodymium magnetic forceps for single-port laparoscopic cholecystectomy显示文摘 | Guillermo D Luis Durand Julia?n De | | 0，，： | 1 |
| 16 | Cell-wall polysaccharide modifications during postharvest ripening of papaya fruit (Carica papaya) 显示文摘 | Guillermo D M Franco M L | 2004 | Postharvest Biology and Technology2004，33，： | 1 |
| 17 | New results on the synthesis of PID controllers 显示文摘 | J S Guillermo D Aniruddha S P Bhattaeharyya | 2002 | IEEE Trans Auto Control2002，47，2： | 1 |
| 18 | Persistence of oxidative stress after heart transplantation:a comparative study of patients with heart transplant versus chronic stable heart failure显示文摘 | Osvaldo P Pablo C Guillermo D A | 2002 | Rev Esp Cardiol2002，55，8： | 1 |
| 19 | Comparison of glomerular filtration rate between greyhounds and non-greyhound dogs 显示文摘 | Wm T D Guillermo C C Anthony J F | 2006 | Journal of Veterinary Internal Medicine2006，20，3： | 1 |
| 20 | New results on the synthesis of PID controllers显示文摘 | Aniruddha D Bhattacharyya S P | 2002 | IEEE Trans Auto Control2002，47，2： | 1 |
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