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| 1 | China's lakes at present:Number,area and spatial distribution显示文摘Based on 11004 satellite images from CBERS CCD and Landsat TM/ETM,changes in the spatial characteristics of all lakes in China were determined following pre-established interpretation rules.This dataset was supported by 6843 digital raster images(1:100000 and 1:50000),a countrywide digital vector dataset(1:250000),and historical literature.Comparative data were corrected for seasonal variations using precipitation data.There are presently 2693 natural lakes in China with an area greater than 1.0 km2,excluding reservoirs.These lakes are distributed in 28 provinces,autonomous regions and municipalities and have a total area of 81414.6 km2,accounting for-0.9% of China's total land area.In the past 30 years,the number of newly formed and newly discovered lakes with an area greater than 1.0 km2 is 60 and 131,respectively.Conversely,243 lakes have disappeared in this time period. | MA RongHua YANG GuiShan DUAN HongTao JIANG JiaHu WANG SuMin FENG XueZhi LI AiNong KONG FanXiang XUE Bin WU JingLu LI ShiJie | 2011 | Science China Earth Sciences2011，54，2： | 79 |
| 2 | Non-stationary water-level fluctuation in China's Poyang Lake and its interactions with Yangtze River显示文摘Seasonal water-level fluctuations(WLF) play a dominate role in lacustrine ecosystems. River-lake interaction is a direct factor in changes of seasonal lake WLF, especially for those lakes naturally connected to upstream and downstream rivers. During the past decade, the modification of WLF in the Poyang Lake(the largest freshwater lake in China) has caused intensified flood and irrigation crises, reduced water availability, compromised water quality and extensive degradation of the lake ecosystem. There has been a conjecture as to whether the modification was caused by its interactions with Yangtze River. In this study, we investigated the variations of seasonal WLF in China's Poyang Lake by comparing the water levels during the four distinct seasons(the dry season, the rising season, the flood season, and the retreating season) before and after 2003 when the Three Gorge Dam operated. The Water Surface Slope(WSS) was used as a representative parameter to measure the changes in river-lake interaction and its impacts on seasonal WLF. The results showed that the magnitude of seasonal WLF has changed considerably since 2003; the seasonal WLF of the Poyang Lake have been significantly altered by the fact that the water levels both rise and retreat earlier in the season and lowered water levels in general. The fluctuations of river-lake interactions, in particular the changes during the retreating season, are mainly responsible for these variations in magnitude of seasonal WLF. This study demonstrates that WSS is a representative parameter to denote river-lake interactions, and the results indicate that more emphasis should be placed on the decrease of the Poyang Lake caused by the lowered water levels of the Yangtze River, especially in the retreating season. | DAI Xue WAN Rongrong YANG Guishan | 2015 | Journal of Geographical Sciences2015，25，3： | 18 |
| 3 | 杜仲、千年健对去卵巢大鼠骨质疏松症的治疗作用及其机理探讨显示文摘目的:探讨具有温补肾阳作用的单味中药杜仲、千年健对去卵巢所致大鼠骨质疏松症的治疗作用及其机理。方法:将72只雌性Wistar大鼠随机分为空白对照组、假手术组、模型组、阳性对照组、杜仲组以及千年健组6组。给药3个月后,采用骨组织形态计量学方法对不脱钙骨切片进行形态计量,免疫组化和原位杂交法检测大鼠胫骨OB和MSC OPG、RANKL蛋白及其mRNA表达。结果:与模型组相比,杜仲组、千年健组胫骨TBV%显著增高,TRS%明显降低,千年健组TFS%、MAR、OSW明显降低,杜仲组无显著性变化;千年健组OB和MSC OPG蛋白及其mRNA的表达显著升高,RANKL蛋白及其mRNA表达明显降低;杜仲组OB和MSC RANKL蛋白及其mRNA表达明显降低。结论:千年健不仅可以增加OB和MSC OPG蛋白及其mRNA表达,还能抑制RANKL蛋白及其mRNA的表达,而杜仲是通过抑制OB和MSC RANKL蛋白及其mRNA表达达到治疗骨质疏松症作用的。 | 张颖 Gary Guishan Xiao 荣培晶 刘梅洁 汪文莱 王少君 于智敏 刘红 潘静华 于峥 赵宏艳 鞠大宏 | 2011 | 中国中医基础医学杂志2011，17，9： | 17 |
| 4 | Using Fuzzy Theory and Variable Weights for Water Quality Evaluation in Poyang Lake, China显示文摘Achieving water purity in Poyang Lake has become a major concern in recent years, thus appropriate evaluation of spatial and temporal water quality variations has become essential. Variations in 11 water quality parameters from 15 sampling sites in Poyang Lake were investigated from 2009 to 2012. An integrative fuzzy variable evaluation(IFVE) model based on fuzzy theory and variable weights was developed to measure variations in water quality. Results showed that: 1) only chlorophyll-a concentration and Secchi depth differed significantly among the 15 sampling sites(P < 0.01), whereas the 11 water quality parameters under investigation differed significantly throughout the seasons(P < 0.01). The annual variations of all water quality variables except for temperature, electrical conductivity, suspended solids and total phosphorus were considerable(P < 0.05). 2) The IFVE model was reasonable and flexible in evaluating water quality status and any possible ′bucket effect′. The model fully considered the influences of extremely poor indices on overall water quality. 3) A spatial analysis indicated that anthropogenic activities(particularly industrial sewage and dredging) and lake bed topography might directly affect water quality in Poyang Lake. Meanwhile, hydrological status and sewage discharged into the lake might be responsible for seasonal water quality variations. | LI Bing YANG Guishan WAN Rongrong ZHANG Lu ZHANG Yanhui DAI Xue | 2017 | Chinese Geographical Science2017，27，1： | 15 |
| 5 | 巴戟天对卵巢切除所致大鼠骨质疏松症的治疗作用及机理探讨显示文摘目的:探讨巴戟天对卵巢切除所致大鼠骨质疏松症的治疗作用及其机理。方法:将60只雌性Wistar大鼠随机分为5组,即空白对照组、假手术组、模型组、阳性对照组和巴戟天组,每组12只。摘除大鼠双侧卵巢1个月后,灌胃给予巴戟天水煎剂,给药3个月。采用骨组织形态计量学的方法对大鼠胫骨不脱钙骨切片进行形态计量;采用免疫组化方法检测OB和MSC OPG、RANKL的蛋白表达。结果:与模型组比较,巴戟天组大鼠胫骨TBV%显著增高,TRS%以及TFS%、MAR明显降低,同时OB、MSCRANKL蛋白表达皆显著降低。结论:巴戟天对卵巢切除所致的大鼠骨质疏松症具有一定的治疗作用,能抑制OB和MSC RANKL的蛋白表达,是其能够治疗骨质疏松症的机理之一。 | 王莹 王少君 潘静华 刘红 李艳 付小卫 汪文来 周晟芳 李亚楠 赵红霞 于峥 赵宏艳 张治国 刘梅洁 Gary Guishan Xiao 鞠大宏 | 2012 | 中国中医基础医学杂志2012，18，10： | 11 |
| 6 | Influence of Land Use/Cover Change on Storm Runoff—A Case Study of Xitiaoxi River Basin in Upstream of Taihu Lake Watershed显示文摘Land use/cover change (LUCC) is one of the main boundary conditions which influence many hydrologic processes. In view of the importance of Taihu Lake Watershed in China and the urgency of discovering the impacts of LUCC on storm runoff, two flood events under five land cover scenarios in the Xitiaoxi River Basin of the upstream of Taihu Lake watershed were simulated by distributed hydrologic modeling system HEC-HMS. The influences of each land cover on storm runoff were discussed. It was concluded that under the same rainstorm the ascending order of runoff coefficient and peak flow produced by the 5 different land covers were woodland, shrub, grassland, arable land, and built-up land; the descending order of swelling time were woodland, shrub, grassland, arable land, and built-up land. Scenario of built-up land was the first to reach peak flow, then arable land, grassland, shrub, and woodland. There were close relationships between the runoff coefficients produced by the 5 different land covers. The degrees of impacts on runoff coefficient of land cover change modes were sorted by descending: woodland to built-up land, shrub to built-up land, grassland to built-up land, arable land to built-up land, woodland to arable land, shrub to arable land, arable land to grassland, shrub to grassland, grassland to arable land, and woodland to shrub. Urbanization will contribute to flood disaster, while forestation will mitigate flood disaster. | WAN Rongrong YANG Guishan | 2007 | Chinese Geographical Science2007，17，4： | 8 |
| 7 | 细胞生命进程中microRNA调控的意义显示文摘细胞生命进程经历从生到死多个阶段,涉及基因表达程序在整体机制控制下的一系列协调性改变.遗传信息网络在整体机制中控制基因组表达程序,地位至关重要,是细胞分裂时发生的可遗传性而不涉及DNA链自身序列改变的稳定性分子变化,包括microRNA及其非蛋白编码RNA、DNA甲基化(常发生于CpG岛)及组蛋白尾修饰(影响染色质结构).microRNA是一种由22个左右核苷酸组成的非蛋白编码微小RNA.Bartel等[1,2]于1993年首次从线虫中发现,至2009年已经识别的人类microRNA达900多种.据生物信息学评估,人类基因组有30%~60%受microRNA调控. | 张众 Xiao Gary Guishan 石宇 李连宏 谢丰培 | 2012 | 临床与实验病理学杂志2012，28，5： | 8 |
| 8 | How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes显示文摘在学习 mRNA 表示的一个关键假设是它在蛋白质表示的预言是增进知识的。然而,仅仅有限的研究在酵母探索了 mRNA 蛋白质表示关联或人的纸巾和结果是相对不一致的。我们从 30 个无关的女人在刚孤立的人的传播单核白血球在 mRNA 蛋白质表情上执行了关联分析。为 71 基因的表示蛋白质被确定并且由结合的 2-D 电气泳动识别了集体 spectrometry。相应 mRNA 表达式被 Affymetrix 基因芯片确定。重要关联(r=0.235, P < 0.0001 ) 包括所有学习基因和所有样品为整个数据集被观察。关联在基因本体论的不同生物范畴变化了。例如,最高的关联以细胞的部件为细胞外的区域的基因被完成(r=0.643, P < 0.0001 ) 并且最低关联为规定的基因被获得(r=0.099, P=0.213 ) 以生物过程。在染色体,样品的一半证明为 71 基因的重要积极关联和重要关联在所有样品在平均 mRNA 和平均蛋白质表示层次之间被发现(r=0.296, P < 0.01 ) 。在学习组水平,然而,仅仅五学习基因越过所有样品有重要积极关联。我们的结果显示出在 mRNA 和蛋白质表示层次之间的全面积极关联。然而,中等、变化的关联建议那 mRNA 表情可能有时是有用的,但是远非当然在预言蛋白质表示层次完善。 | Yanfang Guo Peng Xiao Shufeng Lei Feiyan Deng Gary Guishan Xiao Yaozhong Liu Xiangding Chen Liming Li Shan Wu Yuan Chen Hui Jiang Lijun Tan Jingyun Xie Xuezhen Zhu Songping Liang Hongwen Deng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 7 |
| 9 | 针刺治疗原发性骨质疏松症的研究概况与述评显示文摘原发性骨质疏松症(POP)是多发病。据国际骨质疏松基金会的统计数字显示,目前全世界约有2亿人罹患骨质疏松症,发病率位于世界各种常见病的第七位。《骨质疏松症中国白皮书》,据调查估算,2006年中国50岁以上人群中,约有6944万人罹患骨质疏松症;中国卫生部2002年至2005年关于骨质疏松症的调查结果显示患病率为8.8%,名列中国居民慢性病患病率的第三位。 | 刘儒鹏 荣培晶 Gary Guishan Xiao | 2011 | 中国中医基础医学杂志2011，17，12： | 6 |
| 10 | Impacts of Land Cover Changes on Ecosystem Carbon Stocks Over the Transboundary Tumen River Basin in Northeast Asia显示文摘Understanding the effects of land cover changes on ecosystem carbon stocks is essential for ecosystem management and environmental protection, particularly in the transboundary region that has undergone marked changes. This study aimed to examine the impacts of land cover changes on ecosystem carbon stocks in the transboundary Tumen River Basin(TTRB). We extracted the spatial information from Landsat Thematic Imager(TM) and Operational Land Imager(OLI) images for the years 1990 and 2015 and obtained convincing estimates of terrestrial biomass and soil carbon stocks with the InVEST model. The results showed that forestland, cropland and built-up land increased by 57.5, 429.7 and 128.9 km2, respectively, while grassland, wetland and barren land declined by 24.9, 548.0 and 43.0 km2, respectively in the TTRB from 1990 to 2015. The total carbon stocks encompassing aboveground, belowground, soil and litter layer carbon storage pools have declined from 831.48 Tg C in 1990 to 831.42 Tg C in 2015 due to land cover changes. In detail, the carbon stocks decreased by 3.13 Tg C and 0.44 Tg C in Democratic People's Republic of Korea(North Korea) and Russia, respectively, while increased by 3.51 Tg C in China. Furthermore, economic development, and national policy accounted for most land cover changes in the TTRB. Our results imply that effective wetland and forestland protection policies among China, North Korea, and Russia are much needed for protecting the natural resources, promoting local ecosystem services and regional sustainable development in the transnational area. | XIANG Hengxing JIA Mingming WANG Zongming LI Lin MAO Dehua ZHANG Da CUI Guishan ZHU Weihong | 2018 | Chinese Geographical Science2018，28，6： | 6 |
| 11 | MicroRNA与乳腺癌侵袭转移的关系显示文摘文献报道显示乳腺原位癌与侵袭癌相关microRNA种类既有相同者,也有相异者。乳腺癌相关microRNA对癌变和(或)转移的调控能力有的兼具二者,有的仅具其一。microRNA对乳腺癌侵袭、转移的作用包括调控癌细胞迁徙、侵袭与生存能力,改变微环境与促进血管生成及启动瘤细胞上皮——间质转变。乳腺癌干细胞在microRNA调控下不仅促进乳腺癌发生,也与癌侵袭转移的发生、发展密切相关。 | 张众 李连宏 Xiao Gray Guishan 石宇 谢丰培 | 2012 | 临床与实验病理学杂志2012，28，7： | 5 |
| 12 | Effects of protein sources for milk replacers on growth performance and serum biochemical indexes of suckling calves显示文摘This study investigated the effects of protein sources for milk replacers on growth performance and serum biochemical indexes of suckling calves. Fifty Chinese Holstein bull calves with similar BW and age were randomly allocated to 5 groups(1 control and 4 treatments) of 10 calves in each group. Five types of milk replacers were designed to have the same level of energy and protein. The protein source for milk replacers of the control group was full milk protein(MP). The protein source of milk replacers of the 4 treatment groups was composed of MP and one vegetable protein(VP)(30 and 70% of total protein). The4 types of VP were soybean protein concentrate(SP), hydrolyzed wheat protein(WP), peanut protein concentrate(PP), and rice protein isolate(RP). Results of the experiment showed: 1) there was no significant difference on average daily gain(ADG) and feed:gain ratio(F:G) among the MP, SP and RP groups(P > 0.05), whereas the ADG and F:G of the WP and PP groups were significantly lower compared with the MP group(P < 0.05); 2) there was not a significant difference in withers height, body length and heart girth among treatment groups compared with the MP group(P > 0.05). Thereby the 4 VP milk replacers had no adverse effects on body size of calves; 3) all groups showed no significant difference in the serum contents of urea nitrogen, total protein, albumin, globulin, β-hydroxybutyrate, growth hormone, insulin-like growth factor-1, and the ratio of albumin to globulin(A:G)(P> 0.05). In conclusion, SP or RP(accounts for 70% of the total protein) as calf milk replacers could substitute MP, whereas wheat gluten and PP had a significant adverse effect on growth performance in this experiment. | Kaiwu Huang Yan Tu Bingwen Si Guishan Xu Jiangpeng Guo Feng Guo Chuntao Yang Qiyu Diao | 2015 | Animal Nutrition2015，，4： | 5 |
| 13 | Analyzing and quantitatively evaluating the organic matter source at different ecologic zones of tidal salt marsh, North Jiangsu Province, China显示文摘In order to explore the effect of different eco-logical zones and their above plants in the organic matter cycling of the whole tidal salt marsh,indicators such as total organic carbon(TOC),total nitrogen(TN),C/N ratio,δ13C and d15N of surface,core sediments,and plants of tidal salt marshes in North Jiangsu Province are analyzed.Subse-quently,distribution regularities of these measurement indi-cators are discussed,and the biogeochemistry processes between sediments and plants are also analyzed.Lastly,the organic matter sources of different ecologic zones in tidal salt marsh are evaluated,and the organic matter accumu-lations in different ecologic zones induced by their plants are also compared.These results indicate that TOC,TN,C/N ratio and δ13C showed obvious zonal distribution.The organic matter sources are dominated by marine input in the silt flat,artemisia schrenkiana flat,and the transition zone between silt and spartina alterniflora flat,and are controlled by terrigenous input in spartina alterniflora flat.Spartina alterniflora plays an important role in the accumulation of organic matter in the whole tidal salt marshes ecosystem.In the study area,the annually increased TOC,organic matter and TN in the spartina alterniflora,artemisia schrenkiana and reed flats reach 6,451,12,043 and 536 t,respectively.The amount of TOC,organic matter and TN accumulated in the spartina alterniflora flat is more than that in other ecological zones,which shows that the spartina alterniflora flat exert a non-replaceable effect on the material cycle and exchange in the whole tidal salt marshes ecosystem. | Jianhua GAO Guishan YANG Weixin OU | 2008 | Frontiers of Environmental Science & Engineering2008，2，1： | 5 |
| 14 | Selenium and Sulfur Systematics of Mafic Dykes in Western Fujian Province,Southern China显示文摘来自三个学习区域的十五件样品(Bancun 辉绿岩女同性恋,巴里角闪石斑粝岩女同性恋, Linzifen 斑粝岩辉绿岩女同性恋) 镇定、分析因为硒(Se ) ,硫(S) ,铜(Cu ) ,专业和踪迹元素。一般来说, Se, S 和 Cu 断然确实相关到对方。S 和 Se 和 S/Se 比率的集中比原始披风(下午) 的相应价值高,并且 Cu/S 比率掉在一个狭窄的范围(0.040.29 ) 里,它与原始披风(0.050.20 ) 的一致。Bancun 辉绿岩女同性恋和巴里角闪石斑粝岩女同性恋在迟了的中生代期间位于 intraplate 环境。海洋的 subduction 是仔细与 magmatic 活动有关。magmatic 活动在 Se 和 S 的交通机制起一个重要作用。因为那些二个组接近了,指责地区,它可以影响 S 和 Se 和另外的元素的分发。在二个组,没有外壳的污染被观察,显示所有分析元素可以来自与平板 subduction 联系的充实的披风 metasomtism。然而, Linzifen 斑粝岩辉绿岩女同性恋位于 intraplate 裂缝环境,并且它的入侵的年龄比另外的二个组旧,原始岩浆来自披风,并且在 S , Se 和 Al2O3 之间有一种异常关系,( La/Sm ) N ,并且所有这些因素能导致更高的 S 和 Se 集中。 | FAN Haifeng WEN Hanjie ZHANG Guishan HU Ruizhong | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 4 |
| 15 | 乳腺癌干性表型癌细胞的临床意义显示文摘乳腺癌是女性最常见的恶性肿瘤,病死率居全球首位。近20年,由于早期发现和辅助治疗的改进,乳腺癌的治疗疗效已明显提升,但很多患者仍面临复发的恐惧和死亡的威胁。现阶段,乳腺癌总体复发率约40%,其中60%~70%的患者发生远处转移。应用常规化疗药物联合治疗,HER-2阳性早期转移性乳腺癌对trastuzumab的反应率为50%-84%,但疗程开始1年内药物即对患者失效。 | 张众 谢丰培 Gary Guishan Xiao | 2014 | 临床与实验病理学杂志2014，30，1： | 3 |
| 16 | Impact of seasonal water-level fluctuations on autumn vegetation in Poyang Lake wetland,China显示文摘Water level fluctuations (WLF) are natural patterns that are necessary for the survival of various plants,and WLF guarantee both the productivity and the biodiversity of wetlands.However,the underlying mechanisms of how changes in vegetation are linked to seasonal WLF remain unclear.Using vegetation and hydrological data from 1989 to 2009,we identified the key seasonal fluctuations and their impacts on vegetation in the Poyang Lake wetland by utilizing a tree-based hierarchical model.According to our results: 1) WLF in summer had significant impacts on both sedges and reeds.The severe summer floods promoted the expansion of sedges,while they inhibited the expansion of reeds;2) WLF in autumn also greatly impacted sedges,while reeds were severely affected in spring.Specifically,we found that low water levels in autumn led to the expansion of sedges,and low water levels in spring led to the expansion of reeds.The results were well corroborated through comparisons of the vegetation distribution patterns over the last two decades (i.e.,the 1990s and 2000s),which may shed light on corresponding water resource and wetland management. | Xue DAI Rongrong WAN Guishan YANG Xiaolong WANG Ligang XU Yanyan LI Bing LI | 2019 | Frontiers of Earth Science2019，13，2： | 3 |
| 17 | Soil Moisture Response to Rainfall in Forestland and Vegetable Plot in Taihu Lake Basin,China显示文摘Soil moisture and its spatial pattern are important for understanding various hydrological,pedological,ecological and agricultural processes.In this study,data of rainfall and soil moisture contents at different depths(10 cm,20 cm,40 cm and 60 cm) in forestland and vegetable plot in the Taihu Lake Basin,China were monitored and analyzed for characteristics of soil moisture variation and its response to several typical rainfall events.The following results were observed.First,great temporal variation of soil moisture was observed in the surface layer than in deeper layer in vegetable plot.In contrast,in forestland,soil moisture had similar variation pattern at different depths.Second,initial soil moisture was an important factor influencing the vertical movement of soil water during rainfall events.In vegetable plot,simultaneous response of soil moisture to rainfall was observed at 10-and 20-cm depths due to fast infiltration when initial soil was relatively dry.However,traditional downward response order occurred when initial soil was relatively wet.Third,critical soil horizon interface was an active zone of soil water accumulation and lateral movement.A less permeable W-B soil horizon interface(40-cm depth) in vegetable plot can create perched water table above it and elevate the soil water content at the corresponding depth.Fourth,the land cover was an effective control factor of soil moisture during small and moderate rainfall events.In the forestland,moderate and small rainfall events had tiny influences on soil moisture due to canopy and surface O horizon interception.Fifth,preferential flow and lateral subsurface interflow were important paths of soil water movement.During large and long duration rainfall events,lateral subsurface flow and preferential flow through surface crack or soil pipe occurred,which recharged the deep soil.However,in more concentrated large storm,surface crack or soil pipe connected by soil macropores was the main contributor to the occurrence of preferential flow.Findings of this study provide a theoretical foundation for sustainable water and fertilizer management and land use planning in the Taihu Lake Basin. | LI Qian ZHU Qing ZHENG Jinsen LIAO Kaihua YANG Guishan | 2015 | Chinese Geographical Science2015，25，4： | 3 |
| 18 | Twenty-seven-year nonunion of a Hoffa fracture in a 46-year-old patient显示文摘 | Yirui Jiang Zhenyu Wang Debao Zhang Guishan Gu | 2015 | Chinese Journal of Traumatology2015，18，1： | 3 |
| 19 | Studies on Cataclastic Lithofacies and Copper Metallogenic Regularity for the Glutenite-type Sareke Copper deposit, Xinjiang显示文摘1 Introduction Large-size glutenite-type copper deposit was controlled by the Mesozoic Sarekebayi intracontinental pull-apart basin in Xinjiang.Strata exposed in the study area include the Mesoproterozoic Akesu Group Complex, | HAN Wenhua FANG Weixuan ZHANG Guishan Lu jia Wang lei JIA Runxing LI Tiancheng | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 3 |
| 20 | Macrophages in immunoregulation and therapeutics显示文摘Macrophages exist in various tissues,several body cavities,and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.Macrophages possess binary M1/M2 macrophage polarization settings,which perform a central role in an array of immune tasks via intrinsic signal cascades and,therefore,must be precisely regulated.Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered.In addition,the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology.Moreover,they are an integral part of the tumor microenvironment,playing a part in the regulation of a wide variety of processes including angiogenesis,extracellular matrix transformation,cancer cell proliferation,metastasis,immunosuppression,and resistance to chemotherapeutic and checkpoint blockade immunotherapies.Herein,we discuss immune regulation in macrophage polarization and signaling,mechanical stresses and modulation,metabolic signaling pathways,mitochondrial and transcriptional,and epigenetic regulation.Furthermore,we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions.Moreover,we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis.Lastly,we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases. | Shanze Chen Abdullah F.U.H.Saeed Quan Liu Qiong Jiang Haizhao Xu Gary Guishan Xiao Lang Rao Yanhong Duo | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 2 |
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