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| 1 | Listening to Turkish classical music decreases patients’anxiety,pain,dissatisfaction and the dose of sedative and analgesic drugs during colonoscopy:A prospective randomized controlled trial显示文摘AIM: To determine whether listening to music decreases the requirement for dosages of sedative drugs, patients’ anxiety, pain and dissatisfaction feelings during colonoscopy and makes the procedure more comfortable and acceptable. METHODS: Patients undergoing elective colonoscopy between October 2005 and February 2006 were randomized into either listening to music (Group 1, n = 30) or not listening to music (Group 2, n = 30). Anxiolytic and analgesic drugs (intravenous midazolam and meperidine) were given according to the patients’ demand. Administered medications were monitored. We determined their levels of anxiety using the State-Trait Anxiety Inventory Test form. Patients’ satisfaction, pain, and willingness to undergo a repeated procedure were self-assessed using a visual analog scale.RESULTS: The mean dose of sedative and analgesic drugs used in group 1 (midazolam: 2.1 ± 1.4, meperidine: 18.1 ± 11.7) was smaller than group 2 (midazolam: 2.4 ± 1.0, meperidine: 20.6 ± 11.5), but without a significant difference (P > 0.05). The mean anxiety level in group 1 was lower than group 2 (36.7 ± 2.2 vs 251.0 ± 1.9, P < 0.001). The mean satisfaction score was higher in group 1 compared to group 2 (87.8 ± 3.1 vs 58.1 ± 3.4, P < 0.001). The mean pain score in group 1 was lower than group 2 (74.1 ± 4.7 vs 39.0 ± 3.9, P < 0.001).CONCLUSION: Listening to music during colonoscopy helps reduce the dose of sedative medications, as well as patients’ anxiety, pain, dissatisfaction during the procedure. Therefore, we believe that listening to music can play an adjunctive role to sedation in colonoscopy. It is a simple, inexpensive way to improve patients’ comfort during the procedure. | Nimet Ovayolu Ozlem Ucan Seda Pehlivan Yavuz Pehlivan Hakan Buyukhatipoglu M Cemil Savas Murat T Gulsen | 2006 | World Journal of Gastroenterology2006，12，46： | 10 |
| 2 | Leptin levels in the differential diagnosis between benign and malignant ascites显示文摘AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites. METHODS: Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFα levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS: In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFα levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION: In patients with malignant ascites, levels of leptin and TNFα were significantly lower than in patients with tuberculous ascites. | Mehmet Buyukberber Mehmet Koruk M Cemil Savas Murat T Gulsen Yavuz Pehlivan Rukiye Deveci Alper Sevinc Serdar Gergerlioglu | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 3 | Inhibition of acid mine drainage and immobilization of heavy metals from copper flotation tailings using a marble cutting waste显示文摘Acid mine drainage(AMD) with high concentrations of sulfates and metals is generated by the oxidation of sulfide bearing wastes. Ca CO_3-rich marble cutting waste is a residual material produced by the cutting and polishing of marble stone. In this study, the feasibility of using the marble cutting waste as an acid-neutralizing agent to inhibit AMD and immobilize heavy metals from copper flotation tailings(sulfide-bearing wastes) was investigated. Continuous-stirring shake-flask tests were conducted for 40 d, and the p H value, sulfate content, and dissolved metal content of the leachate were analyzed every 10 d to determine the effectiveness of the marble cutting waste as an acid neutralizer. For comparison, Ca CO_3 was also used as a neutralizing agent. The average p H value of the leachate was 2.1 at the beginning of the experiment(t = 0). In the experiment employing the marble cutting waste, the p H value of the leachate changed from 6.5 to 7.8, and the sulfate and iron concentrations decreased from 4558 to 838 mg/L and from 536 to 0.01 mg/L, respectively, after 40 d. The marble cutting waste also removed more than 80wt% of heavy metals(Cd, Cr, Cu, Ni, Pb, and Zn) from AMD generated by copper flotation tailings. | Gulsen Tozsin | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，1： | 7 |
| 4 | Accurate positioning of the 24-hour pH monitoring catheter:Agreement between manometry and pH step-up method in two patient positions显示文摘瞄准:在二个不同耐心的位置调查在食道的测压法和 pH 加速方法之间的协议。方法:十八个题目在学习被包括。首先,到更低的食道的括约肌(LES ) 的近似边阶的从鼻子的距离被测量压力计的联盟者。然后一个不同调查者,被使看不见第一研究的结果,用 pH 加速方法测量了一样的距离,与病人在一起正直并且背卧位。对在二种技术之间的同意的一个评价被执行。结果:在背卧位,仅仅一个题目的测量在为正确的放接受的范围(对 LES 3 厘米远侧或近似的 <=) 外面。在正直的位置,在测量的错误在五个题目被认出。Bland-Altman 阴谋表明在大小之间的好同意获得了压力计的联盟者并且由在与在背卧位的病人一起的方法上面的 pH 步。结论:在情况中非压力计的察觉设备的可获得性, pH 加速方法能便于放在背卧位与病人一起监视导管的 24 h pH。如果我们的结果被进一步的研究支持,这应该与怀疑的胃的食道的倒流疾病为题目在临床的实践增加 pH-metry 的使用。 | Mehmet Fatih Can Gokhan Yagci Sadettin Cetiner Mustafa Gulsen Taner Yigit Erkan Ozturk Semih Gorgulu Turgut Tufan | 2007 | World Journal of Gastroenterology2007，13，46： | 6 |
| 5 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 6 | Differences in parents of pediatric liver transplantation and chronic liver disease patients显示文摘BACKGROUND With advancements in the treatment of chronic liver disease(CLD),including liver transplantation(LT),quality of life and satisfaction after LT have become an important issue for pediatric patients and their parents.More evidence-based information is needed to describe and assess the impact of pediatric CLD on parents and the satisfaction of parents with treatment to better understand their needs.AIM To assess the satisfaction of parents of pediatric LT patients and that of parents of pediatric CLD patients METHODS During this survey,data were collected from parents of pediatric patients who underwent LT between January 2010 and April 2017(LT group;n=91)and parents of pediatric patients with chronic liver disease(CLD group;n=94).Group comparisons were made based on the pediatric health-related quality of life(PedsQL)health care parent satisfaction scale,impact on family scale(IFS)and demographic characteristics.The PedsQL was administered to parents during a phone interview and the results were used to assess the health carerelated satisfaction of parents.The IFS was used to assess the impact of the child’s CLD status on the family.Demographic variables such as education level(elementary vs middle vs high vs university),monthly income(low vs middle vs high),and place of residence(village vs town vs city)were compared between CLD and LT parent groups.Finally,PedsQL and IFS results were also analyzed according to demographic variables.RESULTS A total of 185 parents aged 19 to 65 years were included.There were statistically significant differences between the LT and CLD groups in terms of career(P<0.001),monthly income(P=0.016),and education level(P=0.041).According to the PedsQL results,family inclusion,communication,technical skills,emotional needs,and overall satisfaction were significantly different between the groups;the LT group had consistently higher scores(P<0.001).Additionally,scores for the IFS parameters of financial impact,familial-social impact,personal strain,and total impact were consistently higher for the LT group(P<0.001).There were statistically significant relationships between education level,monthly income,and place of residence according to the IFS results but not the PedsQL results.There were inverse relationships between the difficulties that parents experience because of their child’s health and education levels,monthly income,and place of residence.However,no relationship was found between education level,monthly income,or place of residence and satisfaction with health care services provided in the hospital according to the PedsQL results.CONCLUSION Parents of children who underwent LT were very satisfied with the health care services provided to their children.However,they had more difficulties than parents of children with CLD. | Sami Akbulut Gulsen Gunes Hasan Saritas Bahar Aslan Yunus Karipkiz Khaled Demyati Sukru Gungor Sezai Yilmaz | 2020 | World Journal of Clinical Cases2020，8，11： | 3 |
| 7 | Comparison of Milan and UCSF criteria for liver transplantation to treat hepatocellular carcinoma显示文摘AIM:To assess the validity of the Milan and University of California San Francisco(UCSF) criteria and examine the long-term outcome of orthotopic liver transplantation(OLT) in patients with hepatocellular carcinoma(HCC) in a single-center study.METHODS:This study is a retrospective review of prospectively collected data.Between 1998 and 2009,56 of 356 OLTs were performed in patients with HCC.Based on pathological examination of liver explants,patients were retrospectively categorized into 3 groups:Milan +(n = 34),Milan-/UCSF +(n = 7) and UCSF-(n = 14).RESULTS:Median follow-up period was 39.5(1-124) mo.The 5-year overall survival rates in the Milan +,Milan-/UCSF + and UCSF-groups were 87.7%,53.6% and 33.3%,respectively(P < 0.000).Within these groups,tumor recurrence was determined in 5.8%,14.3% and 40% of patients,respectively(P < 0.011).Additionally,the presence of microvascular invasion within the explanted liver had a negative effect on the 5-year disease free survival(74.7% vs 46.7%,P < 0.044).CONCLUSION:The Milan criteria are reliable in the selection of suitable candidates for OLT for the treatment of HCC.For cases of OLT involving living donors,the UCSF criteria may be applied. | Tarkan Unek Sedat Karademir Naciye Cigdem Arslan Tufan Egeli Gulsen Atasoy Ozgul Sagol Funda Obuz Ibrahim Astarcioglu | 2011 | World Journal of Gastroenterology2011，17，37： | 2 |
| 8 | Effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats 显示文摘 | Gulsen S Inci S Yuruk S | 2007 | Neurol Med Chir (Tokyo)2007，47，12： | 1 |
| 9 | A new citrus linkage map based on SRAP, SSR, ISSR, POGP, RGA and RAPD markers 显示文摘 | Gulsen O Uzun A Canan I | 2010 | Euphytica2010，173，2： | 1 |
| 10 | Spontaneous supratentorial intracerebral hemorrhage:does surgery benefit comatose patients?显示文摘 | Yilmaz C Kabatas S Gulsen S | 2010 | Ann indian Acad Neurol2010，13，3： | 1 |
| 11 | Diversity and relationships among Turkish okra germplasm by SRAP and phenotypic marker polymorphism显示文摘 | Gulsen O Karagul S Abak K | 2006 | Biologia2006，62，： | 1 |
| 12 | Treatment of sanitary landfill leachate using a combined anaerobic fluidized bed reactor and Fenton's oxidation显示文摘 | Gulsen H Turan M | 2004 | Environment Engineer Science2004，21，5： | 1 |
| 13 | Fractures of the femoral neck in children:long-term follow-up in 62 hip fractures 显示文摘 | Togrul E Bayram H Gulsen M | 2005 | Injury2005，36，1： | 1 |
| 14 | Design and implementation of a multifrequency near-infrared diffuse optical tomography system 显示文摘 | Gulsen G Xiong B Birgul O | 2006 | Journal of Biomedical Optics2006，11，01： | 1 |
| 15 | Long-term efficacyand safety of lamivudine, entecavir, and tenofovir fortreatment ofhepatitis B virus-related cirrhosis 显示文摘 | Koklu S Tuna Y Gulsen M T al | 2013 | ClinGastroenterol Hepatol2013，11，1： | 1 |
| 16 | Dispersion of microemulsion drops in HEMA hydrogel :a potential ophthalmic drug delivery vehicle 显示文摘 | Gulsen D Chauhan A | 2005 | lnt J Pharm2005，292，： | 1 |
| 17 | Preoperative functional assessment of the recurrent laryngeal nerve in patients with eervical vertebra fxacture:case report显示文摘 | Gulsen S Yilmaz C Calisaneller T | 2009 | Neurosurgcry2009，11，01： | 1 |
| 18 | Pituitary insufficiency: A cause of hypoglycemia in an elderly diabetic patient显示文摘 | P?nar Soysal Gulsen Babacan‐Yildiz Ahmet Turan Isik | 2012 | Geriatrics & Gerontology International2012，，4： | 1 |
| 19 | Prepara- tion and characterization of palladium plated porous glass for hydrogen enrichment 显示文摘 | Ozlem Altinisik Mehem Dogan Gulsen Dogu | 2005 | Catalysis Today2005，105，： | 1 |
| 20 | Chloroplast and nuclear genome analysis of the parentage of lemons显示文摘 | GULSEN O ROOSE M L | 2001 | Journal of the American Society for Horticultural Science2001，126，2： | 1 |
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