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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients显示文摘AIM: To investigate the diagnostic eff icacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP). METHODS: A total of 63 consecutive patients with cirrhotic ascites (38 male, 25 female) tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic ? uid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm3. RESULTS: Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specifi city, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically signif icant effects on diagnostic accuracy. CONCLUSION: Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP. | Serkan Torun Enver Dolar Yusuf Yilmaz Murat Keskin Murat Kiyici Melda Sinirtas Emre Sarandol Selim Gurel Selim Giray Nak Macit Gulten | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 3 | Cytoprotective effects of amifostine,ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats显示文摘AIM:To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine(NAC),amifostine(AMF)and ascorbic acid(ASC)in methotrexate(MTX)-induced hepatotoxicity.METHODS:An MTX-induced hepatotoxicity model was established in 44 male Sprague Dawley rats by administration of a single intraperitoneal injection of20 mg/kg MTX.Eleven of the rats were left untreated(Model group;n=11),and the remaining rats were treated with a 7-d course of 50 mg/kg per day NAC (MTX+NAC group;n=11),50 mg/kg per single dose AMF(MTX+AMF group;n=11),or 10 mg/kg per day ASC(MTX+ASC group;n=11).Eleven rats that received no MTX and no treatments served as the negative control group.Structural and functional changes related to MTX-and the various treatments were assessed by histopathological analysis of liver tissues and biochemical assays of malondialdehyde(MDA),superoxide dismutase(SOD),catalase,glutathione(GSH)and xanthine oxidase activities and of serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and total bilirubin.RESULTS:Exposure to MTX caused structural and functional hepatotoxicity,as evidenced by significantly worse histopathological scores[median(range)injury score:control group:1(0-3)vs 7(6-9),P=0.001]and significantly higher MDA activity[409(352-466)nmol/g vs 455.5(419-516)nmol/g,P<0.05].The extent of MTX-induced perturbation of both parameters was reduced by all three cytoprotective agents,but only the reduction in hepatotoxicity scores reached statistical significance[4(3-6)for NAC,4.5(3-5)for AMF and 6(5-6)for ASC;P=0.001,P=0.001 and P<0.005vs model group respectively].Exposure to MTX also caused a significant reduction in the activities of GSH and SOD antioxidants in liver tissues[control group:3.02(2.85-3.43)μmol/g and 71.78(61.88-97.81)U/g vs model group:2.52(2.07-3.34)μmol/g and 61.46(58.27-67.75)U/g,P<0.05];however,only the NAC treatment provided significant increases in these antioxidant enzyme activities[3.22(2.54-3.62)μmol/g and 69.22(61.13-100.88)U/g,P<0.05 and P<0.01vs model group respectively].CONCLUSION:MTX-induced structural and functional damage to hepatic tissues in rats may involve oxidative stress,and cytoprotective agents(NAC>AMF>ASC)may alleviate MTX hepatotoxicity. | Sami Akbulut Hulya Elbe Cengiz Eris Zumrut Dogan Gulten Toprak Emrah Otan Erman Erdemli Yusuf Turkoz | 2014 | World Journal of Gastroenterology2014，20，29： | 3 |
| 4 | One-year experience in the retinopathy of prematurity: frequency and risk factors, short-term results and follow-up显示文摘· AIM: As a result of the increase in premature births and the advances in neonatal intensive care, retinopathy of prematurity (ROP) remains one of the most important causes of childhood blindness worldwide. The main factors in the development of ROP are gestational age, birth weight and oxygen therapy. ROP continues to gain importance due to the increasing survival rates of more immature babies. · METHODS: Between January 2007 and October 2008, 203 premature infants treated at the Neonatal Intensive Care Unit (NNICU) were prospectively enrolled and the relationship between known risk factors and the occurance of ROP was studied. · RESULTS: ROP in various stages developed in 86 cases (42.4%). Statistically significant correlations were found between the development of ROP and birth weight (P < 0.0001) gestational age (P <0.0001), oxygen treatment and its duration (P <0.0001 and P =0.002), mechanical ventilation (MV) and its duration (P =0,0001 and P =0.0001), apnea(P = 0.001), intraventricular hemorrhage (IVH) (P =0.046), sepsis (P =0.0001), use of erythropoietin (EPO) (P =0.003), the number of blood transfusions and frequency (P =0.0001 and P =0.0001), surfactant application (P =0.0001), the presence of patent ductus arteriosus (PDA) (P =0.001) or bronchopu- lmonary dysplasia (BPD) (P =0.0001). No significant correlations were found between the occurance of ROP and maternal pre-eclampsia (P =0.293), multiple pregnancy (P = 0.218), or hyperbilirubinemia (P =0.494). Severity of ROP was related significantly with birth weight (P =0.0001), but no significant correlation between severity of ROP and gestational age was present. · CONCLUSION: Early description and reduction of the risk factors related with the occurance of ROP with the help of routine screening programs may warrant the prevention of visual loss, however early ophthalmic diagnosis and treatment are still mandatory to provide better visual rehabilitation. · | Sariaydin Mehmet Atlihan Fusun Calkavur Sebnem Olukman Ozgur Ercan Gulten Ozturk Arif Taylan Kaya Kilic Fatma Gokaslan Filiz Altinyaprak Derya Malatyali Rana | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 2 |
| 5 | Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepafitis显示文摘 | Kiyici M Gulten M Gurel S | 2003 | Can J Gastmenterol2003，17，12： | 1 |
| 6 | A study on the op- timum insulation thicknesses of various types of external walls with respect to different materials, fuels and climate zones in Turkey显示文摘 | EKICI B B GULTEN A A AKSOY U T | 2012 | Applied Energy2012，92，： | 1 |
| 7 | Productionand characterisation of enzymatically produced lauric acid esters of fructose显示文摘 | Gulten Sekeroglu Ibel Fadiloglu Esra Ibanoglu | 2002 | Journal of the Science of Food and Agriculture2002，82，13： | 1 |
| 8 | Evaluation of the T helper 17 axis in ankylosing spondylitis显示文摘 | Ali Taylan Ismail Sari Didem Kozaci Arif Yuksel Safak Bilge Yasar Yildiz Gulten Sop Isil Coker Necati Gunay Nurullah Akkoc | 2012 | Rheumatology International2012，，8： | 1 |
| 9 | Kefir improves the efficacy and tolerability of triple therapy in eradicating Helicobacter pylori显示文摘 | Bakar O Yilmaz Y Gulten M | 2011 | J Med Food2011，14，4： | 1 |
| 10 | Biofilm formation in an ice cream plant显示文摘 | Gulten Tiryaki Gunduz Gunnur Tuncel | 2006 | Antonie van Leeuwenhoek2006，，3： | 1 |
| 11 | Chronic black tea administration protects plasma proteins, plasma, liver and kidney lipids against oxidation显示文摘 | Surmen Gur E Gulten T Serdar Z | 2006 | Med Sci Monit2006，12，3： | 1 |
| 12 | Ursodeoxycholic acid and atorvastain in the treatment of nonalcoholic steatohepatitis显示文摘 | KIYICI M GULTEN M GUREL S | 2003 | Can J Gastroenterol2003，17，12： | 1 |
| 13 | Synthesis of clay-based superabsorbent composite and its sorption capabil- ity显示文摘 | Yasernin Buluta Gulten Akcay | 2009 | Journal of Hazardous Materials2009，，171： | 1 |
| 14 | Ursodeoxycholic acid and ator- vastatin in the treatment of nonalcoholic steatohepatitis显示文摘 | Kiyici M Gulten M Gurel S | 2003 | Can J Gastroenterol2003，17，12： | 1 |
| 15 | Kefir improves the efficacy and tolerability of triple therapy in eradicating Helicobacter pylori 显示文摘 | BEKAR O Y1LMAZ Y GULTEN M | 2011 | J Med Food2011，14，4： | 1 |
| 16 | Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis显示文摘 | Kiyici M Gulten M Gurel S | 2003 | Can J Gastroenterol2003，17，12： | 1 |
| 17 | Non - alcoholic steatohepatitis with normal aminotransferase values 显示文摘 | Uslusoy HS Nak SG Gulten M | 2009 | World J Gastroenterol2009，2115，15： | 1 |
| 18 | AML1 amplificationand 17q25 deletion in acase of childhood acute lym-phoblastic leukemia 显示文摘 | Gulten T Yakut T Karkucak M | 2009 | Clin Lab Anal2009，23，6： | 1 |
| 19 | A study on the optimum insulation thicknesses of various types of external walls with respect to different materials, fuels and climate zones in Turkey显示文摘 | Ekici B B Gulten A A Aksoy U T | 2012 | Applied Energy2012，92，： | 1 |
| 20 | Biofilm formation in an ice cream plant显示文摘 | Gulten Tiryaki Gunduz Gunnur Tuncel | 2006 | 2006 (3-4)2006，，3： | 1 |
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