|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 2 | Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardio- metabolic risk factors : systematic review and meta-analysis 显示文摘 | Ashwell M Gunn P Gibson S | 2012 | Obesi Rev2012，13，3： | 1 |
| 3 | Human placental cytotrophoblasts attract monocytes and CD56bright natural killer cells via the actions of monocyte inflammatory protein 1alpha显示文摘 | Drake P M Gunn M D Tsou C L | 2001 | J Exp Med2001，193，： | 1 |
| 4 | Perceived legitimacy of decision making and academic governance pat- terns in higher education; a comparative analysis 显示文摘 | MORTIMER K P GUNNE M G LESLIE D W | 1976 | Research in Higher Education1976，，3： | 1 |
| 5 | Rotavirus neutralizing protein VP7: antigenic determinants investigated by sequence analy- sis and peptide synthesis显示文摘 | GUNN P R SATO F POWELL K F | 1985 | J Virol1985，54，3： | 1 |
| 6 | Pancreatic phospholipase A2 contributes to lung injury in experimental meconium aspiration 显示文摘 | Sippola T Aho H Peuravuori H Lukkarinen H Gunn J Kaapa P | 2006 | Pediatr Res2006，59，5： | 1 |
| 7 | Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data 显示文摘 | Edwards AD Brocklehurst P Gunn A J | 2010 | BMJ2010，340，： | 1 |
| 8 | Early intervention in low-birth-weight premature infant:results through age 5 years from the In2fant Health and Development Program显示文摘 | Brook Gunn Mc Carton C M Casey P H | | 0，，16： | 1 |
| 9 | ER stress triggers apoptosis by activating BH3-only protein Bim显示文摘 | Puthalakath H O'Reilly L A Gunn P | 2007 | Cell2007，129，： | 1 |
| 10 | Rotavirus neutralizing protein VP7:antigenic determinants investigated by sequence analysis and peptide synthesis显示文摘 | Gunn P Sato F Powell K | 1985 | Journalof Virology1985，54，3： | 1 |
| 11 | Interleukin 15- mediated survival of natural killer ceils is determined by interactions among Bim, Noxa and Mcl-1 显示文摘 | Huntington ND Puthalakath H Gunn P | 2007 | Nat Immunol2007，8，8： | 1 |
| 12 | Metabolic and hormonal responses to cooling the fetal sheep in utero显示文摘 | Gunn TR Butler J Gluckman P | 1986 | J Dev Physiol1986，8，： | 1 |
| 13 | Direct validation of annual increments in the otoliths of juvenile southern bluefin tuna, Thunnus maccoyii, by means of a largescale mark-recapture experiment with strontium chloride 显示文摘 | Clear N P Gunn J S Rees A J | 2000 | Fish Bull2000，98，1： | 1 |
| 14 | Rotavirus neutralizing protein VP7: Antigenic determinants investigated by sequence analysis and peptide synthesis显示文摘 | Gunn P R Sato F Powell K F | 1985 | Journal of Virology1985，54，3： | 1 |
| 15 | ER stress triggers apoptosis by activating BH3-only protein Bim显示文摘 | Puthalakath H O′Reilly LA Gunn P | | 0，，11： | 1 |
| 16 | Low Temperature Oxidation of Coal(Ⅲ) : Modelling Spontaneous Combustion in Coal Stockpiles显示文摘 | Krishnaswamy S Agarwal P K Gunn R D | 1996 | Fuel1996，75，3： | 1 |
| 17 | Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim,Noxa and Mcl-1显示文摘 | HUNTINGTON N D PUTHALAKATH H GUNN P | 2007 | Nat Immunol2007，8，8： | 1 |
| 18 | Tooth-implant and implant-supported partial dentures:a 10-year report显示文摘 | Gunne J Astmnd P Lindh T | 1999 | Int Journal of prosthodontics1999，12，3： | 1 |
| 19 | 'Not thrush again',women's experence of post-antibiotic vulvovaginitis显示文摘 | Pirotta M Gunn J Chondroe P | 2003 | Med J Aust2003，179，1： | 1 |
| 20 | Human bronchial epithelial cells express and secrete MMP-12显示文摘 | LAVIGNE MC THAKKER P GUNN J | 2004 | Biochem Biophys Res Commun2004，324，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员