| 1 | Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach显示文摘Objective:To investigate the shared mechanisms of scutellarin in angina pectoris(AP)and ischemic stroke(IS)treatment.Methods:A network pharmacology approach was used to detect the potential mechanisms of scutellarin in AP and IS treatment by target prediction,protein-protein interaction(PPI)data collection,network construction,network analysis,and enrichment analysis.Furthermore,molecular docking simulation was employed to analyze the interaction between scutellarin and core targets.Results:Two networks were established,including a disease-target network and a PPI network of scutellarin targets against AP and IS.Network analysis showed that 14 targets,namely,AKT1,VEGFA,JUN,ALB,MTOR,ESR1,MAPK8,HSP90 AA1,NOS3,SERPINE1,FGA,F2,FOXO3,and STAT1,might be the therapeutic targets of scutellarin in AP and IS.Among them,NOS3 and F2 were recognized as the core targets.Additionally,molecular docking simulation confirmed that scutellarin exhibited a relatively high potential for binding to the active sites of NOS3 and F2.Furthermore,enrichment analysis indicated that scutellarin might exert a therapeutic role in both AP and IS by regulating several important pathways,such as coagulation cascades,mitogen-activated protein kinase(MAPK)signaling pathway,phosphatidylinositol 3 kinase(PI3 K)/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)signaling pathway,Toll-like receptor signaling pathway,hypoxia inducible factor-1(HIF-1)signaling pathway,forkhead box O(Fox O)signaling pathway,tumor necrosis factor(TNF)signaling pathway,adipocytokine signaling pathway,insulin signaling pathway,insulin resistance,and estrogen signaling pathway.Conclusions:The shared underlying mechanisms of scutellarin on AP and IS treatment might be strongly associated with its vasorelaxant,anticoagulant,anti-inflammatory,and antioxidative effects as well as its effect on improving lipid metabolism. | MENG Zi-qi WU Jia-rui ZHU Ying-li ZHOU Wei FU Chang-geng LIU Xin-kui LIU Shu-yu Nl Meng-wei GUO Si-yu | 2021 | Chinese Journal of Integrative Medicine2021，27，1： | 4 |
| 10 | Consolidation and Compression Property of Nanocrystalline NiAl Synthesized by Mechanical Alloying显示文摘The mixture of pure nickel and aluminum powders in the composition of Ni50AI50 was subjected to high energy ball milling. The high energy ball milling to 30 h resulted in the formation of a nanocrystalline NiAl with a grain size of about 10 nm. The as-milled NiAl powder was hot-pressed and the compact with a density of 90% was obtained. It was showed that heating to900℃ and holding for more than 2 h failed to induce the coarsening of the fine nanocrystalin the material, the tendency of grain growth was weak. Compression testing showed that thecompression ductility at room temperature reached about 7%. The ductility increased with theexperimental temperature while the strength decreased drastically at elevated temperature. | Liu, ZG Guo, JT Shi, NL Hu, ZQ | 1996 | Journal of Materials Science & Technology1996，12，1： | 0 |
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