|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of nano-fluorocarbon coating on icing显示文摘 | HONG WANG GUOGENG HE QIQI TIAN | | 0，，： | 1 |
| 2 | Simulation on transportation safety of ice slurry in ice cooling sys- tem of buildings 显示文摘 | Tian Qiqi He Guogeng Wang Hong | 2014 | Energy and Buildings2014，72，： | 1 |
| 3 | Experimentalstudy of the supercooling heat exchanger coated withfluorocarbon coating 显示文摘 | Wang Hong He Guogeng Tian Qiqi | 2012 | Energy and Buildings2012，55，： | 1 |
| 4 | An effectivemethod for preventing ice-blockage in dynamic generationsystem with supercooling water 显示文摘 | Wang Hong He Guogeng Feng Rongzhen | 2014 | InternationalJournal of Refrigeration2014，46，： | 1 |
| 5 | Effects of nano-fluorocarbon coating on icing显示文摘 | Hong Wang Guogeng He Qiqi Tian | 2012 | Applied Surface Science2012，，18： | 1 |
| 6 | Passage arrangement optimization of multi-stream plate-fin heat exchangers显示文摘 | TIAN Qiqi HE Guogeng ZHAO Linshan | 2014 | Applied Thermal Engineering2014，73，1： | 1 |
| 7 | KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer显示文摘Increasing evidences suggest the important role of calcium homeostasis in hallmarks of cancer,but its function and regulatory network in metastasis remain unclear.A comprehensive investigation of key regulators in cancer metastasis is urgently needed.Transcriptome sequencing(RNA-seq)of primary esophageal squamous cell carcinoma(ESCC)and matched metastatic tissues and a series of gain/loss-of-function experiments identified potassium channel tetramerization domain containing 4(KCTD4)as a driver of cancer metastasis.KCTD4 expression was found upregulated in metastatic ESCC.High KCTD4 expression is associated with poor prognosis in patients with ESCC and contributes to cancer metastasis in vitro and in vivo.Mechanistically,KCTD4 binds to CLIC1 and disrupts its dimerization,thus increasing intracellular Ca^(2+)level to enhance NFATc1-dependent fibronectin transcription.KCTD4-induced fibronectin secretion activates fibroblasts in a paracrine manner,which in turn promotes cancer cell invasion via MMP24 signaling as positive feedback.Furthermore,a lead compound K279-0738 significantly suppresses cancer metastasis by targeting the KCTD4-CLIC1 interaction,providing a potential therapeutic strategy.Taken together,our study not only uncovers KCTD4 as a regulator of calcium homeostasis,but also reveals KCTD4/CLIC1-Ca^(2+)-NFATc1-fibronectin signaling as a novel mechanism of cancer metastasis.These findings validate KCTD4 as a potential prognostic biomarker and therapeutic target for ESCC. | Cancan Zheng Xiaomei Yu Taoyang Xu Zhichao Liu Zhili Jiang Jiaojiao Xu Jing Yang Guogeng Zhang Yan He Han Yang Xingyuan Shi Zhigang Li Jinbao Liu Wen Wen Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 8 | Effi cacy of partial and complete resuscitative endovascular balloon occlusion of the aorta in the hemorrhagic shock model of liver injury显示文摘BACKGROUND:Resuscitative endovascular balloon occlusion of the aorta(REBOA)can temporarily control traumatic bleeding.However,its prolonged use potentially leads to ischemia-reperfusion injury(IRI).Partial REBOA(pREBOA)can alleviate ischemic burden;however,its security and eff ectiveness prior to operative hemorrhage control remains unknown.Hence,we aimed to estimate the effi cacy of pREBOA in a swine model of liver injury using an experimental sliding-chamber ballistic gun.METHODS:Twenty Landrace pigs were randomized into control(no aortic occlusion)(n=5),intervention with complete REBOA(cREBOA)(n=5),continuous pREBOA(C-pREBOA)(n=5),and sequential pREBOA(S-pREBOA)(n=5)groups.In the cREBOA and C-pREBOA groups,the balloon was inflated for 60 min.The hemodynamic and laboratory values were compared at various observation time points.Tissue samples immediately after animal euthanasia from the myocardium,liver,kidneys,and duodenum were collected for histological assessment using hematoxylin and eosin staining.RESULTS:Compared with the control group,the survival rate of the REBOA groups was prominently improved(all P<0.05).The total volume of blood loss was markedly lower in the cREBOA group(493.14±127.31 mL)compared with other groups(P<0.01).The pH was significantly lower at 180 min in the cREBOA and S-pREBOA groups(P<0.05).At 120 min,the S-pREBOA group showed higher alanine aminotransferase(P<0.05)but lower blood urea nitrogen compared with the cREBOA group(P<0.05).CONCLUSION:In this trauma model with liver injury,a 60-minute pREBOA resulted in improved survival rate and was effective in maintaining reliable aortic pressure,despite persistent hemorrhage.Extended tolerance time for aortic occlusion in Zone I for non-compressible torso hemorrhage was feasible with both continuous partial and sequential partial measures,and the significant improvement in the severity of acidosis and distal organ injury was observed in the sequential pREBOA. | Yi Shan Yang Zhao Chengcheng Li Jianxin Gao Guogeng Song Tanshi Li | 2024 | World Journal of Emergency Medicine2024，15，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员