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| 1 | Effect of ferrovanadium inoculation on microstructure and properties of high speed steel显示文摘The effect of ferrovanadium inoculation on the microstructure and properties of high speed steel (HSS) used for rolls was studied. The results showed that the as-cast eutectic carbide network tends to be broken after ferrovanadium inoculation, and the carbides are changed to rod-like or nodular shape. After heat treatment, the carbides in the inoculated HSS are spheroidized and distributed more uniformly in the matrix. The impact toughness of high speed steel with ferrovanadium inoculation is obviously improved. The action mechanism of ferrovanadium inoculation on the microstructure of the alloy is also discussed. | Zhang Xipeng Kou Guojun Wu Chunjing Gan Zhaiping Zhao Wanzi Chuan Xiangzhao Ma Ye | 2008 | China Foundry2008，5，2： | 6 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Deriving phosphorus atomic chains from few-layer black phosphorus显示文摘磷原子链,黑磷(BP ) 的最狭窄的 nanostructures,与深入的发展高度相关基于 BP 一个维(1D )nano 电子学部件。在这研究,我们为磷的准备报导一条自顶向下的线路经由在一台传播电子显微镜(TEM ) 内的电子横梁 sculpturing 的原子链。生长和动力学(即,破裂和边移植) 1D,磷链试验性地第一次被捕获。而且,动态行为和同样形成的磷链的联系 energetics 被密度进一步调查功能的理论(DFT ) 计算。这些 1D BP 结构将用作一个新奇平台并且启发 BP 的万用的性质的进一步的探索,这被希望。 | Zhangru Xiao Jingsi Qiao Wanglin Lu Guojun Ye Xianhui Chen Ze Zhang Wei Ji Jixue Li Chuanhong Jin | 2017 | Nano Research2017，10，7： | 2 |
| 4 | Hypoxia-Inducible Factor-1α C1772T Polymorphism and Cancer Risk: A Meta-Analysis Including 18,334 Subjects显示文摘 | Yanwei Ye Min Wang Shuang Hu Yingqiang Shi Xiefu Zhang Ye Zhou Chunlin Zhao Guojun Wang Jianguo Wen Hong Zong | 2014 | Cancer Investigation2014，，4： | 1 |
| 5 | Black phosphorusfield-effect transistors 显示文摘 | Li Likai Yu Yijun Ye Guojun | 2014 | Nature Nanotechnology2014，9，5： | 1 |
| 6 | The correlations between the expression of FGFR4 protein and clinicopathological parameters as well as prognosis of gastric cancer patients显示文摘 | Yan‐Wei Ye Xiefu Zhang Ye Zhou Jianghong Wu Chunlin Zhao Lin Yuan Guojun Wang Chunyan Du Chunmeng Wang Yingqiang Shi | 2012 | Oncol2012，，7： | 1 |
| 7 | Solar dimming and its impact on estimating solar radiation from diurnal temperature range in China, 1961-2007显示文摘 | Ye Jsiansheng Li Fengmin Sun Guojun | 2010 | Theoretical and Applied Climatology2010，101，12： | 1 |
| 8 | Harvesting Big Data to Enhance Supply Chain Innovation Capabilities: An Analytic Infrastructure Based on Deduction Graph 显示文摘 | Kim T Yuanzhu Zhan Guojun Ji Fei Ye Cingter Chang | 2015 | International Journal of Production Economies2015，165，： | 1 |
| 9 | Strategic Guidance & Rigid Control: Innovation of Urban Master Planning in the New Period by Taking Shanghai 2040 Master Plan as an Example显示文摘The reform of urban master planning should make continuous progress to meet the requirements of urban and rural spatial resource control in the urbanization transformation period, considering its role of both strategic guidance and rigid control. As urban development in Shanghai is entering the era of stock-based development, it is important for the Shanghai 2040 Master Plan to upgrade urban strategies to adapt to the transformation environment of urban development, and to adjust the master planning system in line with Shanghai's reality. This article analyzes the development environment and challenges faced by the Shanghai 2040 Master Plan and reflects on the limitations of traditional master planning. To facilitate the spatial development transformation and spatial governance, the article summarizes the innovation ideas of the Shanghai 2040 Master Plan from aspects of functions, outcome framework, control system, organization format, etc. | Zhang Shangwu Jin Zhongmin Wang Xinzhe Zheng Degao Hu Guojun Fang Lan Shi Tingting Wu Kexin Wang Lili Sun Ye Liu Jinxin | 2018 | China City Planning Review2018，27，2： | 0 |
| 10 | New Construction of Quadriphase Golay Complementary Pairs显示文摘Based on an arbitrarily-chosen binary Golay complementary pair(BGCP)(c,d)of even length N,first of all,construct quadriphase sequences a and b of length N by weighting addition and difference of the aforementioned pair with different weights,respectively.Secondly,new quadriphase sequence u is given by interleaving three sequences d,a,and−c,and similarly,the sequence v is acquired from three sequences d,b,and c.Thus,the resultant pair(u,v)is the quadriphase Golay complementary pair(QGCP)of length 3N.The QGCPs play a fairly important role in communications,radar,and so on. | LI Guojun ZENG Fanxin YE Changrong | 2023 | Chinese Journal of Electronics2023，32，5： | 0 |
| 11 | The heterochronic gene Oryza sativa LIKE HETEROCHROMATIN PROTEIN 1 modulates miR156b/c/i/e levels显示文摘The juvenile-to-adult transition in plants involves changes in vegetative growth and plant architecture;the timing of this transition has important implications for agriculture.The microRNA miR156 regulates this transition and shoot maturation in plants.In Arabidopsis thaliana,deposition of histone H3 trimethylation on lysine 27(H3K27me3,a repressive mark)at the MIR156A/C loci is regulated by Polycomb Repressive Complex 1(PRC1)or PRC2,depending on the developmental stage.The levels of miR156 progressively decline during shoot maturation.The amount of H3K27me3 at MIR156A/C loci affects miR156 levels;however,whether this epigenetic regulation is conserved remains unclear.Here,we found that in rice(Oryza sativa),the putative PRC1 subunit LIKE HETEROCHROMATIN PROTEIN 1(OsLHP1),with the miR156–SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)module,affects developmental phase transitions.Loss of OsLHP1 function results in ectopic expression of MIR156B/C/I/E,phenocopy of miR156 overexpression,and reduced H3k27me3 levels at MIR156B/C/I/E.This indicates that OsLHP1 has functionally diverged from Arabidopsis LHP1.Genetic and transcriptome analyses of wild-type,miR156b/c-overexpression,and Oslhp1-2 mutant plants suggest that OsLHP1 acts upstream of miR156 and SPL during the juvenile-to-adult transition.Therefore,modifying the OsLHP1–miR156–SPL pathway may enable alteration of the vegetative period and plant architecture. | Yongtao Cui Jingfei Cheng Shuang Ruan Peipei Qi Wei Liu Hongwu Bian Luhuan Ye Yuping Zhang Jiang Hu Guojun Dong Longbiao Guo Yijing Zhang Qian Qian d Xingming Hu | 2020 | Journal of Integrative Plant Biology2020，62，12： | 0 |
| 12 | Expression of MMP-2 and MMP-13 in Bullous Pemphigoid显示文摘Objective:To investigate the expression and significance of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-13(MMP-13)in bullous pemphigoid(BP)skin lesions.Methods:Immunohistochemical SP method was used to detect the expression of MMP-2 and MMP-13 in 32 BP skin lesions,and compared with 15 normal skin tissues.Results:The expression of MMP-2 in the case group was significantly increased(38.56±10.06)compared to the normal control group(21.20±5.98);the expression of MMP-13 in the case group was significantly augmented(18.62±5.90)compared to the normal control group(11.47±8.484).The expressions of MMP-2 and MMP-13 in the skin lesions of patients with bullous pemphigoid were statistically different from those of normal people(both P<0.05).Compared with the expression of MMP-2 and MMP-13 in bullous pemphigoid,the expression of MMP-2 and MMP-13 was moderately correlated(correlation coefficient was 0.523).Conclusion:The expression of MMP-2 and MMP-13 is significantly increased in bullous pemphigoid skin lesions,suggesting that they may play an important role in the pathogenesis of BP.There is a certain correlation between the expression of MMP-2 and MMP-13,suggesting that the high expression of MMP-13 may play a role in the mechanism that further leads to the high expression of MMP-2. | Haixiang Zhang Xiaoxu Shi Lanying Qin Zishen Zhao Guojun Fu Jun Peng Wenjing Ye | 2020 | Journal of Clinical and Nursing Research2020，4，1： | 0 |
| 13 | SBC(Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu)alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice显示文摘In the context of non-alcoholic fatty liver disease (NAFLD), characterized by dysregulated lipid metabolism in hepatocytes, the quest for safe and effective therapeutics targeting lipid metabolism has gained paramount importance. Sanhuang Xiexin Tang (SXT) and Baihu Tang (BHT) have emerged as prominent candidates for treating metabolic disorders. SXT combined with BHT plus Cangzhu (SBC) has been used clinically for Weihuochisheng obese patients. This retrospective analysis focused on assessing the anti-obesity effects of SBC in Weihuochisheng obese patients. We observed significant reductions in body weight and hepatic lipid content among obese patients following SBC treatment. To gain further insights, we investigated the effects and underlying mechanisms of SBC in HFD-fed mice. The results demonstrated that SBC treatment mitigated body weight gain and hepatic lipid accumulation in HFD-fed mice. Pharmacological network analysis suggested that SBC may affect lipid metabolism, mitochondria, inflammation, and apoptosis—a hypothesis supported by the hepatic transcriptomic analysis in HFD-fed mice treated with SBC. Notably, SBC treatment was associated with enhanced hepatic mitochondrial biogenesis and the inhibition of the c-Jun N-terminal kinase (JNK)/nuclear factor-kappa B (NF-κB) and extracellular signal-regulated kinase (ERK)/NF-κB pathways. In conclusion, SBC treatment alleviates NAFLD in both obese patients and mouse models by improving lipid metabolism, potentially through enhancing mitochondrial biogenesis. These effects, in turn, ameliorate inflammation in hepatocytes. | REN Zhitao XIAO Gemin CHEN Yixin WANG Linli XIANG Xiaoxin YANG Yi WEN Siying XIE Zhiyong LUO Wenhui LI Guowei ZHENG Wenhua QIAN Xiaoxian HAI Rihan YANG Liansheng ZHU Yanhua CAI Mengyin YE Yinong SHI Guojun CHEN Yanming | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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