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| 1 | Circadian clock gene expression regulates cancer cell growth through glutaminase显示文摘夫酸安是为恶意的肿瘤房间的必要氨基酸。使夫酸安产生代射变化的 Glutaminase 到达肿瘤立即在最大的增长前评估的最大的 expressionin。肿瘤房间在日子期间以不同的率成长。我们 postulatedthat 在肿瘤房间的 glutaminase 的活动服从于生理节奏的钟基因的规定。我们测量了由在在六 equispaced 时间的肝和 tumorcells 的即时聚合酶链反应的西方的污点分析和生理节奏的钟基因表示削尖的 glutaminaseby 在一张 12/12 h 光 / 黑暗时间表的单个鼠标今日。结果显示出 thatthe 忍受肿瘤的鼠标,在正常下面日报条件,生理节奏地被乘火车,由正常主机 locomotoractivity 节奏和有韵律的肝钟基因表示思考了。在这些老鼠以内的肿瘤生理节奏地也被组织,由生理节奏的钟基因(Bmal1 ) 的 asreflected 表示。是很显著的的,是肾类型 glutaminase 也在一样的模式 withtumor 显示出生理节奏的节奏在肝癌症异种皮移植模型的生理节奏的钟基因表示,有条件地显示那禁止 glutaminaseactivity 可以为癌症提供一个新目标治疗。 | Aixia Huang Bingbo Bao H Rex Gaskins Haijun Liu Xueli Zhang Liwen Lu Shan Gao Yihai Shi Ming Zhang Yuanzhou Shan Jing Feng Guoxiang Yao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 3 |
| 2 | Carbon Isotope Features of the Sugetbrak Section in the Aksu-Wushi Area, Northwest China: Implications for the Precambrian/Cambrian Stratigraphic Correlations显示文摘The upper Qigeblaq Formation(Fm) dolostones and the Yurtus Fm phosphatic cherts, black shales, limestones, and dolostones are widely distributed in the Precambrian/Cambrian transitional succession of the Aksu-Wushi area. Negative δ13C excursion above the Yurtus Fm/Qigeblaq Fm boundary was determined in this study. The pronounced negative carbon isotope excursion occurs in the phosphatic chert layers at the bottom of the Cambrian Yurtus Fm, below which the first appearance of the Asteridium- Heliosphaeridium-Comasphaeridium(AHC) acritarch assemblage zone. The δ13C curve of the lower part of the Yurtus Fm in the Aksu-Wushi area was found to be correlated with the early Cambrian δ13C curves of the Zhujiaqing Fm(Daibu Member), the lower part of the Yanjiahe Fm on the Yangtze Platform in China, the lower Tal Fm in India, the Sukharikha Fm in Siberia, and the upper part of the Tsagaan Oloom Fm in Mongolia through biostigraphy. The lower part of the Yurtus Fm in the Tarim Basin is at the Nemakit-Daldynian stage, and the Precambrian/Cambrian boundary of the Aksu-Wushi area may be located in the phosphatic chert unit which just below the first appearance AHC acritarch assemblage zone. The negative δ13C excursion(N1) across the Precambrian/ Cambrian boundary in the studied section may have resulted from oceanic overturning and sea level rise. | YAO Chunyan DING Haifeng MA Dongsheng LI Guoxiang | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 3 |
| 3 | Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191显示文摘抄写因素的 DNA 有约束力的性质上的研究在寻找这些因素调整的下游的基因是重要的。在现在的学习,我们在一个 Cy s2His2 类型抄写因素的 DNA 有约束力的性质上报导,锌手指蛋白质 191 (Zfpl91 ) ,它最新被发现了在老鼠起一个重要作用。由构造包含 Zfpl91 的 DNA 有约束力的域的熔化蛋白质,我们由在锌上决定蛋白质的有约束力的特性和依赖描绘了目标 DNA。数据证明 Zfpl91 的 DNA 有约束力的域能明确地绑在 TCAT 重复主题并且在目标 DNA 的多重有约束力的地点之中有合作效果。而且,有约束力的反应依赖于锌。这个工作在基因规定和开发在 Zfpl91 的角色上为进一步的研究提供一个基础。 | Haoyue Wang Ruilin Sun Guoxiang Liu Minghui Yao Jian Fei Hebai Shen | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 3 |
| 4 | Cryptanalysis of a certificateless signcryption scheme in the standard model显示文摘 | Jian Weng Guoxiang Yao Robert H.Deng Min-Rong Chen Xiangxue Li | | 0，，： | 1 |
| 5 | Acoustic absorption performance of polyacrylic composite latex显示文摘 | KANGDE YAO GUOXIANG CHENG TAO LU | 1995 | J Appl Polym Sci1995，58，： | 1 |
| 6 | An Encryption Scheme with Hidden Keyword Search for Outsourced Database显示文摘 | Wang Xiaoming Yao Guoxiang Zhang Zhen | 2011 | Journal of Networks2011，6，12： | 1 |
| 7 | Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria显示文摘Only a small proportion of patients with triple-negative breast cancer benefit from immune checkpoint inhibitor(ICI)targeting PD-1/PD-L1 signaling in combination with chemotherapy.Here,we discovered that therapeutic response to ICI plus paclitaxel was associated with subcellular redistribution of PD-L1.In our immunotherapy cohort of ICI in combination with nab-paclitaxel,tumor samples from responders showed significant distribution of PD-L1 at mitochondria,while non-responders showed increased accumulation of PD-L1 on tumor cell membrane instead of mitochondria.Our results also revealed that the distribution pattern of PD-L1 was regulated by an ATAD3A-PINK1 axis.Mechanistically,PINK1 recruited PD-L1 to mitochondria for degradation via a mitophagy pathway.Importantly,paclitaxel increased ATAD3A expression to disrupt proteostasis of PD-L1 by restraining PINK1-dependent mitophagy.Clinically,patients with tumors exhibiting high expression of ATAD3A detected before the treatment with ICI in combination with paclitaxel had markedly shorter progression-free survival compared with those with ATAD3A-low tumors.Preclinical results further demonstrated that targeting ATAD3A reset a favorable antitumor immune microenvironment and increased the efficacy of combination therapy of ICI plus paclitaxel.In summary,our results indicate that ATAD3A serves not only as a resistant factor for the combination therapy of ICI plus paclitaxel through preventing PD-L1 mitochondrial distribution,but also as a promising target for increasing the therapeutic responses to chemoimmunotherapy. | Xiao-Qing Xie Yi Yang Qiang Wang Hao-Fei Liu Xuan-Yu Fang Cheng-Long Li Yi-Zhou Jiang Shuai Wang Hong-Yu Zhao Jing-Ya Miao Shuai-Shuai Ding Xin-Dong Liu Xiao-Hong Yao Wen-Tao Yang Jun Jiang Zhi-Ming Shao Guoxiang Jin Xiu-Wu Bian | 2023 | Cell Research2023，33，3： | 1 |
| 8 | Diffusion Characteristics of Swells in the North Indian Ocean显示文摘Research on the diffusion characteristics of swells contributes positively to wave energy forecasting, swell monitoring, and early warning. In this work, the South Indian Ocean westerly index(SIWI) and Indian Ocean swell diffusion effect index(IOSDEI) are defined on the basis of the 45-year(September 1957–August 2002) ERA-40 wave reanalysis data from the European Centre for Medium-Range Weather Forecasts(ECMWF) to analyze the impact of the South Indian Ocean westerlies on the propagation of swell acreage. The following results were obtained: 1) The South Indian Ocean swell mainly propagates from southwest to northeast. The swell also spreads to the Arabian Sea upon reaching low-latitude waters. The 2.0-meter contour of the swell can reach northward to Sri Lankan waters. 2) The size of the IOSDEI is determined by the SIWI strength. The IOSDEI requires approximately 2–3.5 days to fully respond to the SIWI. The correlations between SIWI and IOSDEI show obvious seasonal differences, with the highest correlations found in December–January–February(DJF) and the lowest correlations observed in June–July–August(JJA). 3) The SIWI and IOSDEI have a common period of approximately 1 week in JJA and DJF. The SIWI leads by approximately 2–3 days in this common period. | ZHENG Chongwei LIANG Bingchen CHEN Xuan WU Guoxiang SUN Xiaofang YAO Jinglong | 2020 | Journal of Ocean University of China2020，19，3： | 0 |
| 9 | Access control scheme with tracing for outsourced databases显示文摘为了管理动态存取控制并且威慑,在采购数据库上盗版攻击,有跟踪的一个动态存取控制计划被建议。在我们的计划,我们介绍跟踪想法进的叛徒采购数据库,并且作为构造加密和解密过程减少计算,通讯,和存储开销的基本工具采用多项式功能和过滤器功能。为采购数据库比作以前的存取控制计划,我们的计划不能仅仅保护敏感数据免受漏的伤害并且当组会员被换掉,而且规定 trace-and-revoke 特征时,没有装运采购数据回到数据主人,在服务器方面执行可伸缩的加密。当恶意的用户为利润克隆并且卖他们的解密钥匙时,我们的计划能跟踪解密钥匙到恶意的用户并且撤回他们。而且,我们的计划为建立在数据主人和用户之间的解密钥匙避免巨大的消息交换。比作跟踪计划的以前建议的 publickey 叛徒,我们的计划能同时完成完整的串通抵抗,完整的可恢复性,完整的撤回,和黑盒子的可描绘。安全的证明和我们的计划安全、有效的表演表演的分析。 | Xiaoming WANG Guoxiang YAO | 2012 | Frontiers of Computer Science2012，6，6： | 0 |
| 10 | Analysis and Design of Quality Management Platform for the Entire Process of Characteristic Software Talent Training显示文摘At the end of 2021 to create a new model of characteristic software talent training for independent and controllable key software fields,the Ministry of Education and the Ministry of Industry and Information Technology jointly approved the establishment of the first batch of 33 Characteristic Pilot Schools of software.As a member of characteristic software schools,the HIT School of Software has been approved and will focus on the construction of 2 characteristic directions,which are large-scale industrial software and industrial professional application software.In order to achieve the goal,it is urgent to develop a comprehensive management platform to control the entire process of talent training,so that we can standardize,modelling,and digitized the entire process of characteristic software talent training.By relating all aspects of student training with and implementing the ability-index mechanisms,we will continuously collect big-data of the entire process of student growth,and generate multidimensional student ability portraits for evaluating the effect of talent training,and adjust as well as optimizing the growth path for students themselves during their studying.Employers will be able to identify talents accurately and provide effective reference for colleges to adjust training plans.This paper will analyze the needs of the platform,provide demand analysis of the platform,extract the correlation model between training,conclude the relations between ability-index activities and ability indicators,and give a reasonable overall system design scheme. | Guoxiang Fan Lin Yao Yin Chen Yong Guo Yingxin Tian Feng Gao Zhongjie Wang | 2022 | 计算机教育2022，，12： | 0 |
| 11 | Expression of human erythropoietin directed by mWAP promoter in m鈓mary gland of transgenic mice显示文摘The present work has generated transgenic mice with a hybrid gene construct consisting of genomic sequences encoding human erythropoietin (hEPO) and governed by regulatory sequences of mouse whey acidic protein (mWAP). The construct proved effective by transient expression in lactating animal. After introducing hybrid gene construct into single-cell embryo via pronuclear microinjection, surviving embryo are reimplanted into pseudopregnant foster mother mouse. 58 mice of 86 generation zero mice obtained were identified to be positive by PCR-Southern blot and genomic DNA Southern blot methods. The integration rate is 67%. hEPO was expressed in the milk of 16 mice of 39 mice measured by hEPO ELISA kit The expression level gets over 15 μg/mL. | ZHANG Xuchen, CHENG Guoxiang, CHEN Jianquan, CHENG Yong WEI Yingrun1, YAO Wulan, XU Shaofu & LAO Weide1. Institute of Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China 2. Agricultural College, Yangzhou University, Yangzhou 225009, China Correspondence should be addressed to Zhang Xuchen | 2000 | Chinese Science Bulletin2000，45，3： | 0 |
| 12 | Pancreatic cancer–Palliative therapy: surgery (bypass/resection)显示文摘Objective: We compare the outcome of palliative pancreaticoduodenectomy and palliative surgical bypass in patients with advanced pancreatic carcinoma in our hospital. Recent published related articles are also reviewed. Methods: A respective analysis was performed comparing the perioperative parameters and outcome of 20 patients who underwent pancreaticoduodenectomy with a gross suspected cancer residue and 30 patients who underwent a surgical bypass, all of the patients were diagnosed as in advanced stages intra-operatively. Results: The two groups were comparable with patient characteristics, including age, gender, initial symptoms and concomitant major organ diseases. Tumors are similar in size and intra-operatively diagnosed as in advanced stages in both groups. All of the patients in the resection group were microscopically proved having cancer residue. One postoperative mortality occurred in the resection group (5%), zero in the bypass group (P > 0.05). Overall complications were significantly higher in the resection group (30% vs. 0, P < 0.01), including 2 patients developed Acute Respiratory Distress Syndrome (ARDS), zero in the bypass group (P < 0.01); hemorrhage and transfusions in the resection group were much more than that in the bypass group (P < 0.05). Hospital stay after resection was significantly longer than bypass (20 vs. 12 days, P < 0.01). Hospital fee after resection was 4 times more than after bypass (median 61.500 vs. 15. 300 yuan, P < 0.01). Survival was significantly longer after resection (median 12.2 vs. 7.1 months, P < 0.01). Conclusion: Our results show that palliative resection in advanced pancreatic carcinoma lengthens the survival time of the patients, but this is paid for significantly higher complications than bypass. | Xiaoping Chen Guoxiang Yao | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，2： | 0 |
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