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| 1 | Lasers Use in Dental Implantology显示文摘 | Romanos GE Gupta B Yunker M | | 0，，： | 1 |
| 2 | The correlation of clinical perinatal asphyxia with counts of nrbc /100 wbc in cord blood 显示文摘 | Tomar GE Sikarwar SH Gupta SU | 2011 | Obstetrics gynaen2011，2，00： | 1 |
| 3 | Fourth order compact difference scheme for 3D convection diffusion equation with boundary layer on non-uniform grid显示文摘 | ZHANG Jun GE Lixin GUPTA M M | 2000 | Neural Parallel ~ Scientific Computations2000，8，4： | 1 |
| 4 | Effect of the variation inthe ambient moisture on the compaction behavior of powderundergoing roller-compaction and on the characteristics of tablets produced from the post-milled granules显示文摘 | Gupta A Peck GE Miller RW | 2005 | J PharmSci2005，94，10： | 1 |
| 5 | The mitochondrial death pathway ;a promising therapeutic target in diseases 显示文摘 | Gupta S Kass GE Szegezdi E | 2009 | J Cell Mol Med2009，13，6： | 1 |
| 6 | Cranio-orbital primary intraosseous haemangioma 显示文摘 | Gupta T Rose GE Manisali M | 2013 | Eye (Lond)2013，27，11： | 1 |
| 7 | Distal cantilevers and implant dentistry显示文摘 | Romanos GE Gupta B Eckert SE | 2012 | Int J Oral Maxillofac Implants2012，27，5： | 1 |
| 8 | Screening for Downg syndrome: effects, safety, and cost effectiveness of first and second trimester strategies 显示文摘 | Gilbert GE Augood C Gupta | 2001 | BMJ2001，323，7310： | 1 |
| 9 | The mitochondrial death pathway:A promising therapeutic target in Diseases显示文摘 | Gupta S Kass GE Szegezdi E | | 0，，06： | 1 |
| 10 | Real-time near-infrared monitoring of content uniformity,moisture content,compact density,tensile strength,and Young's modulus of roller compacted powder blends显示文摘 | GUPTA A PECK GE MILLER RW | 2005 | J Pharm Sci2005，94，7： | 1 |
| 11 | A study of the antiulcer activity of diazepam and other tranquillosedatives in albino rats 显示文摘 | Gupta MB Nath R Gupta GE | 1985 | Clinical Exp Pharmacol1985，12，1： | 1 |
| 12 | Pharmacotherapy of onychomycosis显示文摘 | Baran R Gupta AK Piérard GE | 2005 | Expert Opin Pharmacother2005，6，： | 1 |
| 13 | The mitochondrial death pathway: a promising therapeutic target in diseases 显示文摘 | Gupta S Kass GE Szegezdi E | 2009 | J Cell Mol Med2009，13，： | 1 |
| 14 | Fourth Order Compact Difference Schemes for 3D Convection Diffusion Equation withBoundary Layers on Nonuniform Grid显示文摘 | Zhang J Ge L X Gupta M M | 2000 | Neural ParaUelkScientific Compuations2000，8，： | 1 |
| 15 | Fourth order compact difference schemes for 3D convection diffusion equation with boundary layers on non-uniform grid 显示文摘 | Zhang J Ge L X Gupta M M | 2000 | Neural Par- allel & Scientific Computations2000，8，： | 1 |
| 16 | Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis显示文摘BACKGROUND The expression of amino acid transporters is known to vary during acute pancreatitis(AP)except for LAT1(slc7a5),the expression of which remains stable.LAT1 supports cell growth by importing leucine and thereby stimulates mammalian target of rapamycin(mTOR)activity,a phenomenon often observed in cancer cells.The mechanisms by which LAT1 influences physiological and pathophysiological processes and affects disease progression in the pancreas are not yet known.AIM To evaluate the role of LAT1 in the development of and recovery from AP.METHODS AP was induced with caerulein(cae)injections in female and male mice expressing LAT1 or after its knockout(LAT1 Cre/LoxP).The development of the initial AP injury and its recovery were followed for seven days after cae injections by daily measuring body weight,assessing microscopical tissue architecture,mRNA and protein expression,protein synthesis,and enzyme activity levels,as well as by testing the recruitment of immune cells by FACS and ELISA.RESULTS The initial injury,evaluated by measurements of plasma amylase,lipase,and trypsin activity,as well as the gene expression of dedifferentiation markers,did not differ between the groups.However,early metabolic adaptations that support regeneration at later stages were blunted in LAT1 knockout mice.Especially in females,we observed less mTOR reactivation and dysfunctional autophagy.The later regeneration phase was clearly delayed in female LAT1 knockout mice,which did not regain normal expression of the pancreas-specific differentiation markers recombining binding protein suppressor of hairless-like protein(rbpjl)and basic helixloop-helix family member A15(mist1).Amylase mRNA and protein levels remained lower,and,strikingly,female LAT1 knockout mice presented signs of fibrosis lasting until day seven.In contrast,pancreas morphology had returned to normal in wild-type littermates.CONCLUSION LAT1 supports the regeneration of acinar cells after AP.Female mice lacking LAT1 exhibited more pronounced alterations than male mice,indicating a sexual dimorphism of amino acid metabolism. | Cristina M Hagen Eva Roth Theresia Reding Graf François Verrey Rolf Graf Anurag Gupta Giovanni Pellegrini Nadège Poncet Simone Mafalda Rodrigues Camargo | 2022 | World Journal of Gastroenterology2022，28，10： | 0 |
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