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| 1 | Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK显示文摘Objective To explore the effects of resveratrol-induced apoptosis and autophagy in T-cell acute lymphoblastic leukemia(T-ALL) cells and potential molecular mechanisms. Methods The anti-proliferation effect of resveratrol-induced, apoptosis and autophagy on T-ALL cells were detected by using MTT test, immunofluorescence, electronic microscope, and flow cytometry, respectively. Western blotting was performed for detecting changes of apoptosis-associated proteins, cell cycle regulatory proteins and state of activation of Akt, mTOR, p70S6K, 4E-BP1, and p38-MAPK. Results Resveratrol inhibited the proliferation and induced apoptosis and autophagy in T-ALL cells in a dose and time-dependent manner. It also induced cell cycle arrest at G0/G1 phase via up regulating cyclin-dependent kinase(CDK) inhibitors p21 and p27 and down regulating cyclin A and cyclin D1. Western blotting revealed that resveratrol significantly decreased the expression of antiapoptotic proteins(Mcl-1 and Bcl-2) and increased the expression of proapoptotic proteins(Bax, Bim, and Bad), and induced cleaved-caspase-3 in a time-dependent manner. Significant increase in ratio of LC3-II/LC3-I and Beclin 1 was also detected. Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. When autophagy was suppressed by 3-MA, apoptosis in T-ALL cells induced by resveratrol was enhanced.Conclusion Our findings have suggested that resveratrol induces cell cycle arrest,apoptosis,and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways.Autophagy might play a role as a self-defense mechanism in T-ALL cells treated by resveratrol.Therefore,the reasonable inhibition of autophagy in T-ALL cells may serve as a promising strategy for resveratrol induced apoptosis and can be used as adjuvant chemotherapy for T-ALL. | GE Jiao LIU Yan LI Qiang GUO Xia GU Ling MA Zhi Gui ZHU Yi Ping | 2013 | Biomedical and Environmental Sciences2013，26，11： | 38 |
| 2 | Preliminary study on assessment of nutrient transport in the Taihu Basin based on SWAT modeling显示文摘With the Taihu Basin as a study area, using the spatially distributed and mechanism-based SWAT model, preliminary simulations of nutrient transport in the Taihu Basin during the period of 1995~2002 has been carried out. The topography, soil, meteorology and land use with industrial point pollution discharge, the loss of agricultural fertilizers, urban sewerage, and livestock drainages were all considered in the boundary conditions of the simulations. The model was calibrated and validated against water quality monitoring data from 2001 to 2002. The results show that the annual total productions of nitrogen (TN) and phosphorus (TP) into Lake Taihu are 40000t and 2000t respectively. Nutrient from the Huxi Region is a major resource for Lake Taihu. The non-point source (surface source) pollution is the main form of catchment sources of nutrients into Lake Taihu,occupied TN 53% and TP 56% respectively. TN and TP nutrients from industrial point pollution discharge are 30% and 16%, and sewerage in both forms of point source and non-point source are TN 31% and TP 47%. Both the loss of agricultural fertilizers and livestock drainages from the catchment should be paid more attention as an important nutrient source. The results also show that SWAT is an effective model for the simulation of temporally and spatially nutrient changes and for the assessment of the trends in a catchment scale. | LAI Geying, YU Ge & GUI Feng Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing 210008, China The Graduate School of the Chinese Academy of Sciences, Beijing 100039, China Key Lab of Poyang Lake Ecological Environment and Resource Development, Jiangxi Normal University, Nanchang 330027, China | 2006 | Science China Earth Sciences2006，49，z1： | 11 |
| 3 | LBE-DEM coupled simulation of gas-solid two-phase cross jets显示文摘This paper establishes a lattice Boltzmann equation-discrete element method (LBE-DEM) coupled simulation method under the Eulerian-Lagrangian framework at first, and applies it to simulating a two-dimensional gas-solid two-phase cross jet. The gas phase is simulated by the lattice-Boltzmann method via the TD2G9 model; the solid phase is traced by the Lagrangian method and the inter-particle collision is calculated by the DEM method. Three values of the Stokes number St=10, 25, and 50 are simulated under the same mass loading. This paper focuses on the characteristics of vortex structure, particle distribution, and the reverse-flow/rebounding rate in cross jets. We analyze the characteristics of fluid vortex motion, particle cluster distribution, rebounding rate of particles and the influencing factors for them. The results show the existence of joint distribution of discrete clusters and discrete particles in cross jets. Meanwhile, it shows that a larger concentration of particles in the early stage of jet evolution or a smaller Stokes number under the same mass loading can produce a larger rebounding rate. However, the rebounding rate of particles at the late stage, in general, is stable. | GUI Nan XU WenKai GE Liang YAN Jie | 2013 | Science China(Technological Sciences)2013，56，6： | 6 |
| 4 | Sex determination mechanisms and sex control approaches in aquaculture animals显示文摘Aquaculture is one of the most efficient modes of animal protein production and plays an important role in global food security.Aquaculture animals exhibit extraordinarily diverse sexual phenotypes and underlying mechanisms,providing an ideal system to perform sex determination research,one of the important areas in life science.Moreover,sex is also one of the most valuable traits because sexual dimorphism in growth,size,and other economic characteristics commonly exist in aquaculture animals.Here,we synthesize current knowledge of sex determination mechanisms,sex chromosome evolution,reproduction strategies,and sexual dimorphism,and also review several approaches for sex control in aquaculture animals,including artificial gynogenesis,application of sex-specific or sex chromosome-linked markers,artificial sex reversal,as well as gene editing.We anticipate that better understanding of sex determination mechanisms and innovation of sex control approaches will facilitate sustainable development of aquaculture. | Xi-Yin Li Jie Mei Chu-Tian Ge Xiao-Li Liu Jian-Fang Gui | 2022 | Science China(Life Sciences)2022，65，6： | 5 |
| 5 | Analysis and correlation of fluid acceleration with vorticity and Liutex(Rortex)in swirling jets显示文摘The characteristics of the acceleration a and its correlation with the vortex core in the swirling flow are analyzed in this paper.The swirling flows of four swirl numbers(Sn=n S 0,0.10,0.20 and 0.36)are simulated by the direct numerical simulation,and the fluid mass particles from the inlet of the swirling flow are traced as a database for the current study.The correlations of the acceleration a with the vortex identification parameters of R andωare quantified,where R is the parameter of the“Liutex”-method proposed by Prof.Liu,and its early version is“Rortex”.The probability density functions of the included angles of a-R and a-ωare computed,which are used to clarify the geometrical configuration between a and R.The covariance coefficients between a and the parameters of various vortex core criteria(Q,λ2,ΩL,ΩR,ωand R)are computed and their relative levels of correlation are compared.Compared to the velocity,the expectation and the rms of the acceleration magnitudes and its projections on R and the plane perpendicular to R are computed for better explaining the correlation features between a and R.It is found that a and R are always either perpendicular or parallel to each other with the quantized included angles of∠(a,R)=kπ/2,(k=0,1,2).This confirms the role of R which works as the axis of the vortex exclusively. | Nan Gui Hou-bo Qi Liang Ge Peng-Xin Cheng Hao Wu Xing-tuan Yang Ji-yuan Tu Sheng-yao Jiang | 2019 | Journal of Hydrodynamics2019，31，5： | 4 |
| 6 | Numerical simulations of nutrient transport changes in Honghu Lake Basin, Jianghan Plain显示文摘Nutrients transported from catchments are one of the most important sources for lake eutrophication. In this study, the Honghu Lake Basin, located at the middle reaches of the Yangtze River, was chosen as the study area, and the watershed hydrological distribution model SWAT (Soil Water Assessment Tool) was applied to evaluate the trajectory of watershed nutrient transportation over time. Based on the analysis of driving factors, three experiments corresponding to natural, traditional and modern agriculture processes respectively were designed to evaluate the changes of nutrient inputs from catchments under the three environments. The simulation results showed that there were variations in nutrient production and changes in the range and rate. For three periods of the experiments, TN concentrations have changed as 0.12→0.31→1.15 mg/L, and production as 420→1650→6522 T/a; while TP concentrations changed as 0.018→0.057→0.117 mg/L, and production as 78→303→665 T/a. The nutrient transportation experienced slowly long-term increases during 1840―1950, then showed a relatively rapid increase during the period of 1950―1980s and the period from 1980 to early 1990s, with increasing rate of 1.4% and 2.4% respectively. And from the later 1990s to now, an obviously increasing trend with 15% increasing rate occurred. The effect from human activities on the watershed nutrient transportation increased rapidly, and had become a dominant factor in changes of the nutrient transportation. | GUI Feng YU Ge | 2008 | Chinese Science Bulletin2008，53，15： | 4 |
| 7 | Comparative assessment and analysis of Rortex vortex in swirling jets显示文摘Recently, a new definition, called Rortex, was proposed to quantify the purely rotational motion of fluids. In this work, based on the DNS data, the Rortex is used to assess and visualize the rotational motion and structure of the vortex in swirling jets in comparison with other kinds of vortex criteria, including Q , λ2,vorticity and Ω criteria. The Rortex vector,Ω, Q and criteria are found to be better than the vorticity criterion for the vortex core identification. The vector triangle formed by the Rortex R , the nonrotational shear S , and the vorticity R is analyzed to give mechanical explanations, especially of the effect of the non-rotational shear on the rotation of fluids. In addition, the probability density distributions (PDF) of the Rortex R , the nonrotational shear S, and the vorticity R are computed. The peak value of the PDF of the vorticity could be used to explain the pure rigid rotation effect and the combination effects of the rigid rotation and the non?rotational shear. | Nan Gui Liang Ge Peng-xin Cheng Xing-tuan Yang Ji-yuan Tu Sheng-yao Jiang | 2019 | Journal of Hydrodynamics2019，31，3： | 3 |
| 8 | Study protocol:A cross-sectional study on psychology and behavior investigation of Chinese residents,PBICR显示文摘Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the public.Method:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were selected.The questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot issues.Data analysis will be performed after questionnaire return.Results:Data collection is ongoing.These findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families. | Yu-Jia Wang Ayidana Kaierdebieke Si-Yuan Fan Rui-Feng Zhang Meng-Jie Huang Han Li Xiao-Nan Sun Qi-Yu Li Wen-Jia Meng Wen-Yu Wu Zhi Lin Jing-Yao Liu Xin-Pei Wang Yun-Chou Wu Jing-Qi Tang Yi-Ke Sun Ke Chen Pu Ge Wai-Kit Ming Casper Zhang Zheng Feei Ma Lei Feng Xin-Yue Zhang Yu-Yao Niu Yu-Pei Yan Yi-Le Jin Guang-Ze Gao Shuang Dai Yu-Liu Li Yue Tan Yi-Wei Wu Qi Zhang Gui Gui Xian-Li Pan Yan-Ming Liao Xian-Qi Zhao Ya-Ting Zhang Hui-Yi Chen Yue-Wei Qiu Xiao-Min Fu Jiang-Ling Zhou Dan Li Ke-Han Li Meng-Wei Xu Zhe Wang Yue-Qi Wang Yong Ma Xin-Ying Sun Yi-Bo Wu | 2022 | Psychosomatic Medicine Research2022，4，3： | 3 |
| 9 | LBE–DEM simulation of inter-phase heat transfer in gas–solid cross jets显示文摘Lattice-Boltzmann equation(LBE)–Discrete element method(DEM)coupled simulation of a twodimensional gas–solid cross jet is performed,focusing on the gas-particle two-way coupling effect on heat transfer characteristics.The Reynolds number is 1000,and particle Stokes numbers are 10,25,and 50 under the same number flow rate of particles.The gas phase temperature field and particle distribution as well as the inter-phase heat transfer characteristics are studied and analyzed.The dominating effects,i.e.the mean temperature difference and mean heat transfer coefficient between the gas–solid phases,for the pre-and post-collision stages of the cross jets are illustrated respectively.The change of dominating roles is related to the dynamical response characteristics of particles. | Nan Gui Wenkai Xu Liang Ge Jie Yan | 2014 | Chinese Science Bulletin2014，59，20： | 2 |
| 10 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 11 | Impulsive effect of continuous-time neural networks under pure structural variations 显示文摘 | GUI Z J GE W G | 2007 | International Journal of Bifurcation and Chaos2007，17，6： | 1 |
| 12 | Periodic solutions of nonautonomous cellular neural networks with impulses显示文摘 | GUI Z J GE W G | 2007 | Chaos Solitons and Fractals2007，32，： | 1 |
| 13 | Periodic solutions of nonautonomous cellular neural networks with impulses显示文摘 | GUI Z J GE W G | 2007 | Chaos Solitons and Fractals2007，32，5： | 1 |
| 14 | Existence and uniqueness of periodic solutions of nonautonomous cellular neural networks with impulses显示文摘 | GUI Z J GE W G | 2006 | Physics Letters A2006，354，： | 1 |
| 15 | The effect of harvesting on a pledator-prey system with stage Structure显示文摘 | GUI Z GE W | 2005 | Ecol Model2005，187，： | 1 |
| 16 | Periodic solutions to a second order nonlinear neutral functional differential equation in the critical case显示文摘 | Lu Shiping Gui Zhanji Ge Weigao | 2006 | Nonlinear Analysis2006，64，： | 1 |
| 17 | Analysis of the UHRF1 ex- pression in serum and tissue for gastric cancer detection 显示文摘 | Ge M Gui Z Wang X | 2015 | Siomarkers2015，20，3： | 1 |
| 18 | Impact of The Number of Image Planes of Real-Time Three-Dimensional Echocardiography on the Accuracy of Left Atrial and Ventricular Volume Measurements显示文摘 | Fang Li Qian Wang Gui Hua Yao Peng Fei Zhang Zhi Ming Ge Mei Zhang Yun Zhang | 2007 | Ultrasound in Medicine & Biology2007，，1： | 1 |
| 19 | Response to children's physical and mental needs during the COVID-19 outbreak显示文摘School closure and stay-at-home,as a part of non-pharmaceutical interventions (NPI),have been implemented in China since February as an effective way to mitigate the spread of the virus during the COVID-19 outbreak.As concerns rose over the potential impacts of such NPI measures on children's health,such as longer exposure to digital screens,irregular sleep pattern,weight gain,and loss of cardiorespiratory fitness [1],the Chinese Government,experts on public health,educators on school health,and teachers have been making joint and massive efforts to provide distance learning with well-organized online courses to help. | Xiao-Bo Zhang Yong-Hao Gui Xiu Xu Da-Qian Zhu Yi-Hui Zhai Xiao-Ling Ge Hong Xu | 2020 | World Journal of Pediatrics2020，16，3： | 1 |
| 20 | Periodic Solution for Nonautonomous Bidirectional Associative Memory Neural Net- works with Impulses 显示文摘 | GUI Zhanji YANG Xiaosong GE Weigao | 2007 | Neurocomputing2007，70，1315： | 1 |
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