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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Defining the specific physiological requirements for c- Myc in T cell development显示文摘 | Douglas NC Jacobs H Bothwell AL | 2001 | Nat Immunol2001，2，4： | 2 |
| 3 | An anti-apoptotic protein human survivin is a direct inhibitor of Caspase-3 and-7显示文摘 | Sung B J Cho YS Kim H J Ha NC Hwang JI | 2001 | Biochenistry2001，40，4： | 1 |
| 4 | Effect of spiz, onolactone on left ventricular systolic and diastolic function in patients with early stage chronic kidney disease显示文摘 | Edwards NC Ferro CJ Kirkwood H | 2010 | Am J Cardiol2010，106，10： | 1 |
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| 6 | Measurement of di reetional thermal properties of biomaterials显示文摘 | Bhavaraju NC Cao H Yuan DY | 2001 | Ieee Trans on Biomed Eng2001，2，： | 1 |
| 7 | Intron 1 and exron 1 alpha estrogen receptor gene polymorphisms in women with endometriosis显示文摘 | Sato H Noqiera-de-Souza NC Damora P | 2008 | Fertil Steril2008，90，6： | 1 |
| 8 | Plague dynamics are driven by climate variation显示文摘 | Stenseth NC Sarnia NI Viljugrein H | 2006 | Proc Natl Acad Sci USA2006，103，13： | 1 |
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| 10 | Laparoscopic major hepatectomy: a systematic literature review and comparison of 3 techniques 显示文摘 | Lin NC Nitta H Wakabayashi G | 2013 | Ann Surg2013，257，2： | 1 |
| 11 | Biomechanical evaluation of a microstructured zirconia implant by a removal torque comparison with a standard Ti-SLA implant显示文摘 | Bormann KH Gellrich NC Kniha H | | 0，，10： | 1 |
| 12 | Fractures of the radial head and neck: current concepts in management 显示文摘 | Tejwani NC Mehta H | 2007 | J Am Acad Orthop Surg2007，15，7： | 1 |
| 13 | Arterial embolization:a novel approach to thyroid ablative therapy for Graves's disease显示文摘 | Xiao H Zhuang W Wang S Yu B Chen G Zhou M Wong NC | 2002 | J Clin Endocrinol Metab2002，8，： | 1 |
| 14 | Magnitude of the inflammatory response to cardiopulmonary bupass and its relation to adverse clinical outcomes 显示文摘 | Holmes J H Connolly NC Paull D L | 2002 | Inflamm Res2002，51，12： | 1 |
| 15 | Plague dynamics are driven by climate variation显示文摘 | Stenseth NC Samia NI Viljugrein H | 2006 | Proc Natl Acad Sci USA2006，103，13： | 1 |
| 16 | Flow cytometic reticulocyte maturity index:a useful laboratory parameter of erythroportic activity in anemia显示文摘 | Davis B H Ornvold K Bigelow NC | 1995 | Cytometry1995，22，： | 1 |
| 17 | Cloning, characterization, and expression of the human TINag-RP gene encoding a novel putative extracellular matrix protein? 显示文摘 | Brtinm NC Wex T Wex H | 2000 | Biochem Biophy Re Commtmications2000，271，2： | 1 |
| 18 | Responses of neurones of the rat suprachiasmatic nucleus to retinal illumination under photopic and scotopic conditions 显示文摘 | Aggelopoulos NC Meissl H | 2000 | J Physiol2000，523，1： | 1 |
| 19 | Serum parathy- roid hormone and risk of adverse outcomes in patients with stable coronary heart disease 显示文摘 | Grandi NC Breitling LP Hahmann H | 2011 | Heart2011，97，15： | 1 |
| 20 | p53 mutations in mammary ductal carcinoma in situ but not in epithelial hyperplasias 显示文摘 | Done S J Arneson NC Ozcelik H | 1998 | Can Res1998，58，4： | 1 |
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