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| 1 | A new microchannel capillary flow assay (MCFA) platform with lyophilized chemiluminescence reagents for a smartphone-based POCT detecting malaria显示文摘There has been a considerable development in microfluidic based immunodiagnostics over the past few years which has greatly favored the growth of novel point-of-care-testing(POCT).However,the realization of an inexpensive,low-power POCT needs cheap and disposable microfluidic devices that can perform autonomously with minimum user intervention.This work,for the first time,reports the development of a new microchannel capillary flow assay(MCFA)platform that can perform chemiluminescence based ELISA with lyophilized chemiluminescent reagents.This new MCFA platform exploits the ultra-high sensitivity of chemiluminescent detection while eliminating the shortcomings associated with liquid reagent handling,control of assay sequence and user intervention.The functionally designed microchannels along with adequate hydrophilicity produce a sequential flow of assay reagents and autonomously performs the ultra-high sensitive chemiluminescence based ELISA for the detection of malaria biomarker such as PfHRP2.The MCFA platform with no external flow control and simple chemiluminescence detection can easily communicate with smartphone via USB-OTG port using a custom-designed optical detector.The use of the smartphone for display,data transfer,storage and analysis,as well as the source of power allows the development of a smartphone based POCT analyzer for disease diagnostics.This paper reports a limit of detection(LOD)of 8 ng/mL by the smartphone analyzer which is sensitive enough to detect active malarial infection.The MCFA platform developed with the smartphone analyzer can be easily customized for different biomarkers,so a hand-held POCT for various infectious diseases can be envisaged with full networking capability at low cost. | Sthitodhi Ghosh Kashish Aggarwal Vinitha T.U Thinh Nguyen Jungyoup Han Chong H.Ahn | 2020 | Microsystems & Nanoengineering2020，6，1： | 7 |
| 2 | Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B显示文摘 | S. U.Kim Y. S.Seo J. Y.Cheong M. Y.Kim J. K.Kim S. H.Um S. W.Cho S. K.Paik K. S.Lee K.‐H.Han S. H.Ahn | 2010 | Alimentary Pharmacology & Therapeutics2010，，3： | 1 |
| 3 | 时间、质量和成本──这就是一切吗?─—传统的目标目录在同步工程中显示出明显的不足显示文摘人们时常把流行语时间、质量和成本称为组织措施和其他生产措施的目标。然而,这三个目标并未从内容上进行过明确的定义;另一方面,它们也并非反映出组织重新设计的潜在目标。本文将在同步工程的范围内,针对产品开发的重组状况看重提出两个方面的问题,即质量和环境保护。 | H.Ahn H.Dyckhoff 林琪 | 1998 | 工业工程与管理1998，3，4： | 0 |
| 4 | Editorial comment on:“Systemic treatment of hepatocellular carcinoma:an EASL position paper”显示文摘Hepatocellular carcinoma is the most common cancer of the liver and worldwide,the sixth most common cancer and the third most common cause of cancer related deaths(1).The management and treatment of this disease requires a multi-disciplinary approach,which is observed in the staging and classification.In 1999,the development of the Barcelona Clinic Liver Cancer(BCLC)classification system helped to guide the appropriate treatments based on stage.While patients with stage A disease would be candidates for locoregional treatment including surgical resection,liver transplantation or liver directed therapy,treatment in patients with intermediate(B)or advanced(C)stage disease would be palliative,where the recommendation would for systemic therapy. | Daniel H.Ahn Tanios Bekaii-Saab | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 0 |
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