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| 1 | HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression显示文摘Diffuse large B-cell lymphoma(DLBCL) is an aggressive type of non-Hodgkin’s lymphoma. A total of 10%-15% of DLBCL cases are associated with myelocytomatosis viral oncogene homolog(MYC) and/or B-cell lymphoma-2(BCL2) translocation or amplification. BCL2 inhibitors have potent anti-tumor effects in DLBCL;however, resistance can be acquired through up-regulation of alternative anti-apoptotic proteins. The histone deacetylase(HDAC) inhibitor chidamide can induce BIM expression, leading to apoptosis of lymphoma cells with good efficacy in refractory recurrent DLBCL. In this study, the synergistic mechanism of chidamide and venetoclax in DLBCL was determined through in vitro and in vivo models. We found that combination therapy significantly reduced the protein levels of MYC, TP53, and BCL2 in activated apoptotic-related pathways in DLBCL cells by increasing BIM levels and inducing cell apoptosis. Moreover, combination therapy regulated expression of multiple transcriptomes in DLBCL cells, involving apoptosis, cell cycle, phosphorylation, and other biological processes, and significantly inhibited tumor growth in DLBCL-bearing xenograft mice. Taken together, these findings verify the in vivo therapeutic potential of chidamide and venetoclax combination therapy in DLBCL, warranting pre-clinical trials for patients with DLBCL. | Cancan LUO Tiantian YU Ken H.YOUNG Li Yu | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，8： | 2 |
| 2 | Raised levels of plasma interleukin‐1β in major and postviral depression显示文摘 | B. M.Owen D.Eccleston I. N.Ferrier H.Young | 2008 | Acta Psychiatrica Scandinavica2008，，3： | 1 |
| 3 | Interfacial microstructure and mechanical properties of diffusion-bonded joints of titanium TC4 (Ti-6Al-4V) and Kovar (Fe-29Ni-17Co) alloys显示文摘Diffusion bonding is a near net shape forming process that can join dissimilar materials through atomic diffusion under a high pressure at a high temperature.Titanium alloy TC4(Ti-6 Al-4 V)and 4 J29 Kovar alloy(Fe-29 Ni-17 Co)were diffusely bonded by a vacuum hot-press sintering process in the temperature range of 700-850°C and bonding time of 120 min,under a pressure of 34.66 MPa.Interfacial microstructures and intermetallic compounds of the diffusion-bonded joints were characterized by optical microscopy,scanning electron microscopy,X-ray diffraction(XRD)and energy dispersive spectroscopy(EDS).The elemental diffusion across the interface was revealed by electron probe microanalysis.Mechanical properties of joints were investigated by micro Vickers hardness and tensile strength.Results of EDS and XRD indicated that(Fe,Co,Ni)-Ti,TiNi,Ti_2Ni,TiNi_2,Fe_2 Ti,Ti_(17) Mn_3 and Al_6 Ti_(19) were formed at the interface.When the bonding temperature was raised from 700 to 850°C,the voids of interface were reduced and intermetallic layers were widened.Maximum tensile strength of joints at 53.5 MPa was recorded by the sintering process at 850°C for 120 min.Fracture surface of the joint indicated brittle nature,and failure took place through interface of intermetallic compounds.Based on the mechanical properties and microstructure of the diffusion-bonded joints,diffusion mechanisms between Ti-6 Al-4 Vtitanium and Fe-29 Ni-17 Co Kovar alloys were analyzed in terms of elemental diffusion,nucleation and growth of grains,plastic deformation and formation of intermetallic compounds near the interface. | Ting-feng Song Xiao-song Jiang Zhen-yi Shao De-feng Mo De-gui Zhu Min-hao Zhu Christina H.Young Zhi-ping Luo | 2017 | Journal of Iron and Steel Research(International)2017，24，10： | 1 |
| 4 | 后现代科学和西方文明(英文)显示文摘Much of the American academy1 has come to reject the concept of natural science developed by Western civilization and has replaced it with postmodern ideology2. Most importantly, this misguided contempt for Western science has contributed to placing America in a non-competitive and perilous3 position relative to other industrialized nations because of a lack of college graduates with degrees in science, technology, engineering, and math, or STEM4. | William H.Young 胡凯 | 2019 | 大学英语2019，0，6： | 0 |
| 5 | Cross-talk between Myc and p53 in B-cell lymphomas显示文摘Myc and p53 proteins are closely associated with many physiological cellular functions,including immune response and lymphocyte survival,and are expressed in the lymphoid organs,which are sites for the development and activation of B-cell malignancies.Genetic alterations and other mechanisms resulting in constitutive activation,rearrangement,or mutation of MYC and TP53 contribute to the development of lymphomas,progression and therapy resistance by gene dysregulation,activation of downstream anti-apoptotic pathways,and unfavorable microenvironment interactions.The cross-talk between the Myc and p53 proteins contributes to the inferior prognosis in many types of B-cell lymphomas.In this review,we present the physiological roles of Myc and p53 proteins,and recent advances in understanding the pathological roles of Myc,p53,and their cross-talk in lymphoid neoplasms.In addition,we highlight clinical trials of novel agents that directly or indirectly inhibit Myc and/or p53 protein functions and their signaling pathways.Although,to date,these trials have failed to overcome drug resistance,the new results have highlighted the clinical efficiency of targeting diverse mechanisms of action with the goal of optimizing novel therapeutic opportunities to eradicate lymphoma cells. | Li Yu Tian-Tian Yu Ken H.Young | 2019 | Chronic Diseases and Translational Medicine2019，5，3： | 0 |
| 6 | 仿生手臂的竞赛显示文摘在法国作家儒勒·凡尔纳1865年的小说《从地球到月球》中,有一个虚构的巴尔的摩枪炮俱乐部,其中的成员都是美国南北战争中的伤残老兵,他们无休止地寻找并征服新的敌人。他们在战争中不断创造致命的新型武器装备,待战争结束时,他们“四个人只有一条胳膊,六个人只有两条腿”,这些自学成才的伤残武器制造工匠,决定再次利用他们的技能制造新型可发射武器:火箭船。 | Britt H.Young Gabriela Hasbun(图) | 2022 | 科技纵览2022，，10： | 0 |
| 7 | Intensive chemotherapy and sequential hematopoietic stem cell transplantation:Is it necessary for high-risk T-cell lymphoblastic lymphoma?显示文摘Adult T-cell lymphoblastic lymphoma(T-LBL)is characterized by its rarity and poor prognosis,however,it is currently being treated without any internationally recognized therapies[1].Acute lymphocytic leukemia(ALL)-like chemotherapy,such as the Berlin-Frankfurt-Muenster(BFM)regimen or the fractionated cyclophosphamide,vincristine,doxorubicin,and dexamethasone(hyperCVAD)regimen,is currently being widely used[2]. | Ken H.Young | 2021 | Cancer Communications2021，41，3： | 0 |
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