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| 1 | Upper gastrointestinal tract capsule endoscopy using a nurse-led protocol: First reported experience显示文摘AIM To test the feasibility and performance of a novel upper gastrointestinal(GI) capsule endoscope using a nurse-led protocol. METHODS We conducted a prospective cohort analysis of patients who declined gastroscopy(oesophagogastroduodenoscopy, OGD) but who consented to upper GI capsule endoscopy. Patients swallowed the upper GI capsule following ingestion of 1 liter of water(containing simethicone). A series of positional changes were used to exploit the effects of water flow and move the upper GI capsule from one gravity-dependent area to another using a nurse-led protocol. Capsule transit time, video reading time, mucosal visualisation, pathology detection and patient tolerance was evaluated.RESULTS Fifty patients were included in the study. The mean capsule transit times in the oesophagus and stomach were 28 s and 68 min respectively. Visualisation of the following major anatomical landmarks was achieved(graded 1-5: Poor to excellent): Oesophagus, 4.8(± 0.5); gastro-oesophageal junction(GOJ), 4.8(± 0.8); cardia, 4.8(± 0.8); fundus, 3.8(± 1.2); body, 4.5(± 1); antrum, 4.5(± 1); pylorus, 4.7(± 0.8); duodenal bulb, 4.7(± 0.7); second part of the duodenum(D2), 4.7(± 1). The upper GI capsule reached D2 in 64% of patients. The mean video reading time was 48 min with standard playback mode and 20 min using Quickview(P = 0.0001). No pathology was missed using Quickview. Procedural tolerance was excellent. No complications were seen with the upper GI capsule. CONCLUSION The upper GI capsule achieved excellent views of the upper GI tract. Future studies should compare the diagnostic accuracy between upper GI capsule and OGD. | Hey-Long Ching Ailish Healy Victoria Thurston Melissa F Hale Reena Sidhu Mark E McAlindon | 2018 | World Journal of Gastroenterology2018，24，26： | 9 |
| 2 | Capsule endoscopy:Current practice and future directions显示文摘Capsule endoscopy(CE)has transformed investigation of the small bowel providing a non-invasive,well tolerated means of accurately visualising the distal duodenum,jejunum and ileum.Since the introduction of small bowel CE thirteen years ago a high volume of literature on indications,diagnostic yields and safety profile has been presented.Inclusion in national and international guidelines has placed small bowel capsule endoscopy at the forefront of investigation into suspected diseases of the small bowel.Most commonly,small bowel CE is used in patients with suspected bleeding or to identify evidence of active Crohn’s disease(CD)(in patients with or without a prior history of CD).Typically,CE is undertaken after upper and lower gastrointestinal flexible endoscopy has failed to identify a diagnosis.Small bowel radiology or a patency capsule test should be considered prior to CE in those at high risk of strictures(such as patients known to have CD or presenting with obstructive symptoms)to reduce the risk of capsule retention.CE also has a role in patients with coeliac disease,suspected small bowel tumours and other small bowel disorders.Since the advent of small bowel CE,dedicated oesophageal and colon capsule endoscopes have expanded the fields of application to include the investigation of upper and lower gastrointestinal disorders.Oesophageal CE may be used to diagnose oesophagitis,Barrett’s oesophagus and varices but reliability in identifying gastroduodenal pathology is unknown and it does not have biopsy capability.Colon CE provides an alternative to conventional colonoscopy for symptomatic patients,while a possible role in colorectal cancer screening is a fascinating prospect.Current research is already addressing the possibility of controlling capsule movement and developing capsules which allow tissue sampling and the administration of therapy. | Melissa F Hale Reena Sidhu Mark E McAlindon | 2014 | World Journal of Gastroenterology2014，20，24： | 9 |
| 3 | Logistic regression for geologically constrained mapping of gold potential,Baguio district显示文摘 | Carranza E J M Hale M | | 0，，03： | 1 |
| 4 | Alternative mechanisms of action of cationicantimicrobial peptides on bacteria显示文摘 | Hale J D- Hancock R E | | Expert Rev Anti InfectT h e r0，05，06： | 1 |
| 5 | DetaiLed polybrominated diphenyl ether(PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures显示文摘 | LA A G M J HALE R C HARVEY E | 2006 | Environ Sci Technol2006，40，： | 1 |
| 6 | Optimal simultaneous structural and control design of maneuvering flexible spacecraft 显示文摘 | Hale A L Dahl W E Lisowski R J | 1984 | Journal of Guidance Control and Dynamics1984，8，1： | 1 |
| 7 | Practical joint domain localized adaptive processing in homogeneous and nonhomogeneous environments显示文摘 | Adve R S Hale T E Wicks M C | 2000 | IEE Proc Radar Sonar Navigation2000，11，2： | 1 |
| 8 | Where are Porphyry Copper Deposits Spatially Localized? A Case Study in Benguet Province,Philippines显示文摘 | Carranza E G M Hale M | 2002 | Natural Resources Research2002，11，1： | 1 |
| 9 | Magnetic domain observation by electron microscopy显示文摘 | Hale M E Fuller H W Rubinstein H | 1959 | J Appl Phys1959，30，： | 1 |
| 10 | Manipulation of coupled osmotic flows for stabilization of shale exposed to water- based drilling fluids 显示文摘 | vanOort E Hale A H Mody F K | 1995 | SPE 304991995，，： | 1 |
| 11 | Quantifyingthe Total and Bioavailable Polycyclic Aromatic Hydrocarbons andDioxins in Biochars 显示文摘 | HALE S E LEHMAN N J RUTHERFOR D D | 2012 | Environmental Science & Technology2012，46，5： | 1 |
| 12 | The role of in- sulin and proinsulin in the regulation of t riglyceride met abolism 显示文摘 | Byrn e CD Wareham N J Hales CN | 1997 | Exp Clin Endocrinol Diabetes1997，105，15： | 1 |
| 13 | Lactation persistency: Insights from mammary cell pro liferation studies 显示文摘 | CAPUCO A V ELIAS S E HALE S A | 2003 | J Anita Sci2003，81，3： | 1 |
| 14 | Climate changeand human health:present and future risks显示文摘 | MCMICHAEL A J WOODRUFF R E HALES S | 2006 | Lancet2006，367，9513： | 1 |
| 15 | Effects of chronic alcohol treatment on the synthesis, sialylation, and disposition of nascent apolipoprotein E by peritoneal macrophages of ratsl-3显示文摘 | GHOSH P HALE E A MAYUR K | 2000 | Am Soci Clin Nutr2000，72，： | 1 |
| 16 | Muhiple evolutionary origin of pyridoxal-5 '-phosphate-dependent amino acid decarboxylases 显示文摘 | Sandmeier E Hale T I Christen P | 1994 | Eur J Biochem1994，21，： | 1 |
| 17 | Fixed - point continuation for €1-minimization: Methodology and convergence 显示文摘 | Hale E T Yin W Zhang Y | 2008 | SIAMJournal on Optimization2008，19，3： | 1 |
| 18 | Effects of varying bulk densities of steam-flaked corn and dietary roughage concentration on in vitro fermentation,performance,carcass quality,and acid-base balance measurements in finishing steers显示文摘 | Hales K E McMeniman J P Leibovich J | 2010 | Journal of Animal Science2010，88，3： | 1 |
| 19 | The Sorption andDesorption of Phosphate-P,Ammonium-N and Nitrate-N in CacaoShell and Corn Cob Biochars显示文摘 | HALE S E ALLING V MARTINSEN V | 2013 | Chemosphere2013，91，11： | 1 |
| 20 | Frozen storage stability of whole and headless freshwater prawns ( Machrobranchium rosenbergii ) 显示文摘 | HALE M B WATERS M E | 1981 | Marine Fish Review1981，42，： | 1 |
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