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| 1 | Paleoproterozoic volcanic rocks in the southern margin of the North China Craton, central China:Implications for the Columbia supercontinent显示文摘The volcanic rocks of the Xiong’er Group are situated in the southern margin of the North China Craton(NCC).Research on the Xiong er Group is important to understand the tectonic evolution of the NCC and the Columbia supercontinent during the Paleoproterozoic.In this study,to constrain the age of the Xiong’er volcanic rocks and identify its tectonic environment,we report zircon LA-ICP-MS data with Hf isotope,whole-rock major and trace element compositions and Sr-Nd-Pb-Hf isotopes of the volcanic rocks of the Xiong’er Group.The Xiong’er volcanic rocks mainly consist of basaltic andesite,andesite.dacite and rhyolite,with minor basalt.Our new sets of data combined with those from previous studies indicate that Xiong’er volcanism should have lasted from 1827 Ma to 1746 Ma as the major phase of the volcanism.These volcanics have extremely low MgO.Cr and Ni contents,are enriched in LREEs and LILEs but depleted in HFSEs(Nb,Ta,and Ti),similar to arc-related volcanic rocks.They are characterized by negative zirconεHft values of-17.4 to 8.8,whole-rock initial 87Sr/86Sr values of 0.7023 to 0.7177 andεNd(t)values of-10.9 to 6.4.and Pb isotopes(206Pb/204Pb=14.366-16.431,207Pb/204Pb=15.106-15.371,208Pb/204Pb=32.455-37.422).The available elemental and Sr-Nd-Pb-Hf isotope data suggest that the Xiong’er volcanic rocks were sourced from a mantle contaminated by continental crust.The volcanic rocks of the Xiong’er Group might have been generated by high-degree partial melting of a lithospheric mantle that was originally modified by oceanic subduction in the Archean.Thus,we suggest that the subduction-modified lithospheric mantle occurred in an extensional setting during the breakup of the Columbia supercontinent in the Late Paleoproterozoic,rather than in an arc setting. | Changming Wang Xinyu He Emmanuel John M. Carranza Chengmin Cui | 2019 | Geoscience Frontiers2019，10，4： | 14 |
| 2 | Chemical Compositions and Distribution Characteristics of Cements in Longmaxi Formation Shales, Southwest China显示文摘Shale gas resources have been regarded as a viable energy source, and it is of great significance to characterize the shale composition of different cements, such as quartz and dolomite. In this research, chemical analysis and the multifractal method have been used to study the mineral compositions and petrophysical structures of cements in shale samples from the Longmaxi Formation, China. X-ray diffraction, electron microprobe, field emission scanning electron microscopy, cathodoluminescence microscopy and C-O isotope analyses confirmed that cements in the Longmaxi Formation shales are mainly composed of Fe-bearing dolomite and quartz. Fe-bearing dolomite cements concentrate around dolomite as annuli, filling micron-sized inorganic primary pores. Quartz cements in the form of nanoparicles fill primary inter-crystalline pores among clay minerals. Theoretical calculation shows that the Fe-bearing dolomite cements formed slightly earlier than the quartz cements, but both were related to diagenetic illitization of smectite. Moreover, multifractal analysis reveals that the quartz cements are more irregularly distributed in pores than the Fe-bearing dolomite cements. These results suggest that the plugging effect of the quartz cements on the primary inoraganic pore structures is the dominant factor resulting in low interconnected porosity of shales, which are unfavorable for the enrichment of shale gas. | Wenda Zhou Shuyun Xie Zhengyu Bao Emmanuel John M. Carranza Lei Lei Zhenzhen Ma | 2019 | Journal of Earth Science2019，30，5： | 12 |
| 3 | Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model显示文摘AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse model.METHODS: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-test). No gender differences in the serum liver parameters [bilirubin; alanine aminotransferase(ALT); aspartate aminotransferase and alkaline phosphatase(AP)] were found. In vitro, the administration of IL-1β resulted in a significant increase in HSC proliferation [0.94 ± 0.72 arbitrary units(A.U.) in untreated controls, 1.12 ± 0.80 A.U. at an IL-1β concentration of 0.1 ng/m L and 1.18 ± 0.73 A.U. at an IL-1β concentration of 1 ng/m L in samples from n = 6 donor animals; P < 0.001; analyses of variance(ANOVA)]. Proliferation was reduced significantly by the addition of 2.5 μg/m L Anakinra(0.81 ± 0.60 A.U. in untreated controls, 0.92 ± 0.68 A.U. at an IL-1β concentration of 0.1 ng/m L, and 0.91 ± 0.69 A.U. at an IL-1β concentration of 1 ng/m L; in samples from n = 6 donor animals; P < 0.001; ANOVA) suggesting an anti-proliferative effect of this clinically approved IL-1 receptor antagonist. The FDH assay showed this dose to be non-toxic in HSCs. In vivo, Anakinra had no effect on the hepatic hydroxyprolinecontent, liver serum tests(ALT and AP) and profibrotic(collagen 1α1, collagen 1α2, transforming growth factor-β, and TIMP-1) and anti-fibrotic [matrix metalloproteinase 2(MMP2), MMP9 and MMP13 ] gene expression after 4 wk of treatment. Furthermore, the hepatic IL-1β and F4/80 m RNA expression levels were unaffected by Anakinra treatment.CONCLUSION: IL-1β expression is associated with the degree of liver fibrosis in Abcb4^(-/-) mice and promotes HSC proliferation. IL-1 antagonism shows antifibrotic effects in vitro but not in Abcb4^(-/-) mice. | Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk | 2016 | World Journal of Hepatology2016，8，8： | 3 |
| 4 | Development and cross-sectional validation of the Childhood Asthma Control Test显示文摘 | Andrew H. Liu Robert Zeiger Christine Sorkness Todd Mahr Nancy Ostrom Somali Burgess Jacqueline Carranza Rosenzweig Ranjani Manjunath | 2007 | The Journal of Allergy and Clinical Immunology2007，，4： | 2 |
| 5 | Geologically constrained probabilistic mapping of gold potential, Baguio District, Philippines 显示文摘 | Emmanuel J Carranza M Martin H | 2000 | Natural Resources Research2000，9，3： | 1 |
| 6 | Logistic regression for geologically constrained mapping of gold potential,Baguio district显示文摘 | Carranza E J M Hale M | | 0，，03： | 1 |
| 7 | Refractory Gold-bearing Ores:A Review of Treatment Methods and Recent Advances in Biotechnological Techniques显示文摘 | Iglesias N Carranza F | 1994 | Hydrometallurgy1994，34，3： | 1 |
| 8 | Where are Porphyry Copper Deposits Spatially Localized? A Case Study in Benguet Province,Philippines显示文摘 | Carranza E G M Hale M | 2002 | Natural Resources Research2002，11，1： | 1 |
| 9 | Re-cent Gravity Models as a Result of the Lunar Pro- spector Mission显示文摘 | Konopliv A S Asmar S W Carranza E | 2001 | Icarus2001，15，1： | 1 |
| 10 | new numerical technique for high-speed evaluation of power system frequency显示文摘 | Moore P J Carranza R D John A T | 1994 | IEE Proc-Gener Transm Distrib1994，141，5： | 1 |
| 11 | Measuring forest frag- mentation using multitemporal forest cover maps: Forest loss and spatial pattern analysis in the Gran Chaco, cen- tral Argentina显示文摘 | Carranza M L Hoyos L Frate L | 2015 | Landscape Urban Plan2015，143，： | 1 |
| 12 | Identification of variant-spe- cific surface proteins in Giardia muris trophozoites显示文摘 | Ropolo AS Saura A Carranza PG | 2005 | Infect Immun2005，73，8： | 1 |
| 13 | Behavioural changes and the adaptive diversification of pigeons and doves显示文摘 | Oriol L Sol D Carranza S | 2013 | Proc Biol Sci2013，280，1755： | 1 |
| 14 | Silver Catalyzed IBES Process:Application to a Spanish Copper-Zinc Sulphide Concentrate显示文摘 | Carranza F Palencia I Romero R | 1997 | Hydrometallurgy1997，44，12： | 1 |
| 15 | Dualiry metal oxide semi-condutor-PN junction in the Al/silicon rich oxids/Si structure as a radiation sensor 显示文摘 | Aceves M Camillo J Carranza J | 2000 | Thin Solid Films2000，373，： | 1 |
| 16 | A new numeric technique for high speed evaluation of power system frequency显示文摘 | Moore P J Carranza R D Johns A T | 1994 | IEE Proceedings-Generation Transmission and Distribution1994，141，5： | 1 |
| 17 | The complex structure of a benthic community : a multiscale-multianalytical approach to an estuarine sandflat显示文摘 | Luis Gimenez Caterina Dimitriadis Alvar Carranza Unravelling | 2006 | Estuarine Coastal and Shelf Science2006，68，： | 1 |
| 18 | Fuzzy modeling of farmers' knowledge for land suitability classification显示文摘 | SICAT R S CARRANZA E J M NIDUMOLU U B | | 0，，01： | 1 |
| 19 | A hybrid fuzzy weights-of-evidence model for mineral potential mapping显示文摘 | Porwal A Carranza E J M Hale M | 2006 | Natural Resources Research2006，8，： | 1 |
| 20 | Evaluation of pro- collagen I deposition after intense pulsed light treatments at varying parameters in a porcine model 显示文摘 | Iyer S Carranza D Kolodney M | 2007 | J Cosmet Laser Ther2007，9，2： | 1 |
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