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		题名	作者	年代	出处	被引量
	1	Myosin binding protein C:Structural abnormalities in familial hypertrophic cardiomyopathy显示文摘The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction, the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins, actin and titin, remain obscure. In additic n, several intra-domain interactions between adjacent MyBPC molecules have been identified. Although the basic structure of the molecule (a series of immunoglobulin and fibronectin domains) has been elucidated, the assembly of MyBPC in the sarcomere is a topic for debate. By analysing the MyBPC sequence with respect to FHC-causing mutations it is possible to identify individual residues or regions of each domain that may be important either for binding or regulation. This review looks at the current literature, in concert with alignments and the structural models of MyBPC, in an attempt to understand how FHC mutations may lead to the disease state.	Cecily E OAKLEY Brett D HAMBLY Paul MG CURMI Louise J BROWN	2004	Cell Research2004，14，2：	2
	2	Analysis of precipitationrelated motor vehicle collision and injury risk using insurance and police record information for Winnipeg,Canada显示文摘	Mills B N Andrey J Hambly D		0，，05：	1
	3	Strain-damage coupled algorithm for cancellous bone mechano-regulation with spatial function influence显示文摘	Hambli R Soulat D Gasser A	2009	Computer Methods in Applied Mechanics and Engineering2009，198，33：	1
	4	Insights into driver adaptation to inclement weather in Canada 显示文摘	ANDREY J HAMBLY D MILLS B	2013	Journal of Transport Geography2013，28，：	1
	5	Evaluation of an exercise-based treatment for children with reading difficulties 显示文摘	Reynolds D Nicolson R I Hambly H	2003	Dyslexia2003，9，1：	1
	6	Plasma stealth显示文摘	HAMBLING D	2000	New Scientist2000，168，2264：	1
	7	Optimisation of Springback in Bending Processes Using FEM Simulation and Response Surface Method显示文摘	Lepadatr D Hambli R Kobi A etal	2005	International Journal of Advianced Manufacvured Technology2005，27，：	1
	8	Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain显示文摘	Yan B Steen S Hambly D	2009	J Pharm Sci2009，98，10：	1
	9	Optimisation of springback in bending processes using FEM simulation and response surface method 显示文摘	LEPADATU D HAMBLI R KOBI A	2005	Int J Adv Manuf Technol2005，27，：	1
	10	Optimisation of Springback in Bending Processes Using FEM Simulation and Response Surface Method显示文摘	Lepadatu D Hambli R Kobi A etal	2005	International Journal of Advanced Manfacture Technology2005，27，：	1
	11	Effects of iron salts and haemosider in from a thalassaemia patient on oxygenradi ealdamage as measured in the comet assay显示文摘	Anderson D Yardley- JonesA Hambly RJ	2000	Teatog Careinog Mutagen2000，20，1：	1
	12	Damage and fracture simulation during the extrusion processes显示文摘	HAMBLI R BADIE L D	2000	Computer Methods in Applied Mechanics and Engineering2000，186，1：	1
	13	Evaluation of an exercisebased treatment for children with reading difficulties显示文摘	Reynolds D Nieolson RI Hambly H	2003	Dyslexia2003，9，：	1
	14	Effects of iron salts and haemosiderin from a thalassaemia patient on oxygen radi cal damage as measured in the comet assay显示文摘	Anderson D Yardley-Jones A Hambly RJ	2000	Teatog Carcinog Mutagen2000，20，1：	1
	15	Succinimide formation at Asn 55 in the complementarity determining region of a recombinant mono- clonal antibody IgG1 heavy chain显示文摘	Yan B Steen S Hambly D	2009	J Pharm Sci2009，98，10：	1
	16	The effect of sucrose hydrolysis on the stability of protein therapeutics during acceler- ated formulation studies 显示文摘	Banks D D Hambly D M Scavezze J L	2009	J Pharma Sci2009，98，12：	1
	17	Evaluation of an exercise-based treatment for children with reading difficulties 显示文摘	Reynolds D Nieolson RI Hambly H	2003	Dyslexia2003，9，1：	1
	18	Optimisation of springback in bending processes using FEM simulation and response surface method显示文摘	Lepadatu D Hambli R Kobi A	2005	Int J Adv Manuf Technol2005，27，：	1

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